Integrator is a key component of human telomerase RNA biogenesis

[1]  T. Tong,et al.  Mitochondrial Trafficking and Processing of Telomerase RNA TERC. , 2018, Cell reports.

[2]  V. Prassolov,et al.  Protein encoded in human telomerase RNA is involved in cell protective pathways , 2018, Nucleic acids research.

[3]  J. Soutourina Transcription regulation by the Mediator complex , 2017, Nature Reviews Molecular Cell Biology.

[4]  P. Cahan,et al.  Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease. , 2016, The Journal of clinical investigation.

[5]  Michelle S. Scott,et al.  A Polyadenylation-Dependent 3' End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA. , 2015, Cell reports.

[6]  P. Baumann,et al.  Human Telomerase RNA Processing and Quality Control. , 2015, Cell reports.

[7]  P. Cahan,et al.  Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component , 2015, Nature Genetics.

[8]  M. Pagano,et al.  The Integrator complex controls the termination of transcription at diverse classes of gene targets , 2015, Cell Research.

[9]  A. Mosley,et al.  The Exosome Component Rrp6 Is Required for RNA Polymerase II Termination at Specific Targets of the Nrd1-Nab3 Pathway , 2015, PLoS genetics.

[10]  P. Baumann,et al.  Diverse mechanisms for spliceosome-mediated 3′ end processing of telomerase RNA , 2015, Nature Communications.

[11]  E. Blackburn,et al.  An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity. , 2014, Blood.

[12]  B. Sobhian,et al.  Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes , 2014, Nature Communications.

[13]  A. Shilatifard,et al.  Integrator regulates transcriptional initiation and pause release following activation. , 2014, Molecular cell.

[14]  T. Cech,et al.  Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT , 2014, Nucleic acids research.

[15]  A. Hyman,et al.  The human cap-binding complex is functionally connected to the nuclear RNA exosome , 2013, Nature Structural &Molecular Biology.

[16]  C. Gustafsson,et al.  The multitalented Mediator complex. , 2013, Trends in biochemical sciences.

[17]  David A. Scott,et al.  Genome engineering using the CRISPR-Cas9 system , 2013, Nature Protocols.

[18]  Dylan J. Taatjes,et al.  The Mediator complex and transcription regulation , 2013, Critical reviews in biochemistry and molecular biology.

[19]  T. Cech,et al.  3′ terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing , 2013, BMC Molecular Biology.

[20]  K. Neugebauer,et al.  How cells get the message: dynamic assembly and function of mRNA–protein complexes , 2013, Nature Reviews Genetics.

[21]  E. Wagner,et al.  Functional Analysis of the Integrator Subunit 12 Identifies a Microdomain That Mediates Activation of the Drosophila Integrator Complex* , 2013, The Journal of Biological Chemistry.

[22]  S. Abou Elela,et al.  Budding yeast telomerase RNA transcription termination is dictated by the Nrd1/Nab3 non-coding RNA termination pathway , 2012, Nucleic acids research.

[23]  B. Fehse,et al.  A multicolor panel of novel lentiviral "gene ontology" (LeGO) vectors for functional gene analysis. , 2008, Molecular Therapy.

[24]  Katarzyna Sikora,et al.  Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation. , 2007, Molecular cell.

[25]  H. Handa,et al.  NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs. , 2007, Molecular cell.

[26]  S. Buratowski,et al.  Nrd1 interacts with the nuclear exosome for 3' processing of RNA polymerase II transcripts. , 2006, Molecular cell.

[27]  Mohamed-Ali Hakimi,et al.  Integrator, a Multiprotein Mediator of Small Nuclear RNA Processing, Associates with the C-Terminal Repeat of RNA Polymerase II , 2005, Cell.

[28]  E. Petfalski,et al.  RNA Degradation by the Exosome Is Promoted by a Nuclear Polyadenylation Complex , 2005, Cell.

[29]  Mark R. Soboleski,et al.  Green fluorescent protein is a quantitative reporter of gene expression in individual eukaryotic cells , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  K. Collins,et al.  Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs. , 2003, Molecular cell.

[31]  F. Speleman,et al.  Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes , 2002, Genome Biology.

[32]  Jeffrey B. Cheng,et al.  A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ End , 1999, Molecular and Cellular Biology.

[33]  L. Giudice,et al.  Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. , 1998, Cancer research.

[34]  A. Maitra,et al.  Expression of the RNA component of telomerase during human development and differentiation. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[35]  C. Harley,et al.  Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.

[36]  et al.,et al.  The RNA component of human telomerase , 1995, Science.

[37]  E. Blackburn,et al.  Functional evidence for an RNA template in telomerase. , 1990, Science.