Hybrid glass and sol-gel integrated optical waveguides for absorption-based biosensing

A novel integrated optical planar waveguide platform for absorption-based biosensing is demonstrated. The platform integrates surface ion-exchanged channel waveguides with one-step UV patterned sol-gel structures to define the probing regions. Cytochrome c protein was utilized to characterize the device performance. Spectroscopically specific attenuation of approximately 2 dB in the guided signal occurred at 532nm for 1.4 cm long probing region. The estimated level of detection is about 1 pmol/cm2 of surface adsorbed cytochrome c. The proposed structure enables environmentally stable, compact, and inexpensive sensing devices that can be applied to a wide range of biological and chemical species.

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