Neuropsychological Predictors of BOLD Response During a Spatial Working Memory Task in Adolescents: What Can Performance Tell Us About fMRI Response Patterns?

The relationship between standardized neuropsychological test performance and functional magnetic resonance imaging (fMRI) response during cognitive tasks is largely unknown. This exploratory investigation examined the relationship between neuropsychological test performance and fMRI response to a spatial working memory (SWM) task among 49 typically developing adolescents. Participants were administered a variety of neuropsychological tests in the domains of working memory, visuospatial skills, executive functioning, attention, learning and memory, visuomotor skills and processing speed, and language functioning. Neuropsychological domain scores were used to predict fMRI response during a SWM task. Results suggest that in many brain regions, neuropsychological performance negatively predicts fMRI response, suggesting that those teens with better neuropsychological abilities required fewer neural resources to adequately perform the task. This study provides further understanding of how neuropsychological abilities relate to neural activity during fMRI tasks, and provides an important link between neuropsychological and fMRI research. This study was supported by grants R21 AA12519 and R01 AA13419 from the National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD (Dr. Tapert) and the UCSD Fellowship in Biological Psychiatry and Neuroscience. Portions of this study were presented at the annual meeting for the International Neuropsychological Society, February 2003, Honolulu, Hawaii. We would like to thank Greg Brown, Sandra Kindermann, MJ Meloy, Lisa Caldwell, and Lauren Killeen for their valuable contributions to this research.

[1]  R. Dean,et al.  TEST REVIEW: Dean C. Delis, Edith Kaplan & Joel H. Kramer, Delis Kaplan Executive Function System (D-KEFS), The Psychological Corporation, San Antonio, TX, 2001. $415.00 (complete kit) , 2006 .

[2]  Gregory G Brown,et al.  Spatial working memory among middle-aged and older patients with schizophrenia and volunteers using fMRI , 2004, Schizophrenia Research.

[3]  T. Robbins,et al.  Striatal contributions to working memory: a functional magnetic resonance imaging study in humans , 2004, The European journal of neuroscience.

[4]  Hidenao Fukuyama,et al.  The neural basis of executive function in working memory: an fMRI study based on individual differences , 2004, NeuroImage.

[5]  Hidenao Fukuyama,et al.  Functional roles of the cingulo-frontal network in performance on working memory , 2004, NeuroImage.

[6]  S. Pickering,et al.  Working memory skills and educational attainment: evidence from national curriculum assessments at 7 and 14 years of age , 2004 .

[7]  Marcia K. Johnson,et al.  Prefrontal activity associated with working memory and episodic long-term memory , 2003, Neuropsychologia.

[8]  A. Meyer-Lindenberg,et al.  Interindividual differences in functional interactions among prefrontal, parietal and parahippocampal regions during working memory. , 2003, Cerebral cortex.

[9]  Tyrone D. Cannon,et al.  A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. , 2003, The American journal of psychiatry.

[10]  Rosemary Tannock,et al.  Listening Comprehension and Working Memory Are Impaired in Attention-Deficit Hyperactivity Disorder Irrespective of Language Impairment , 2003, Journal of abnormal child psychology.

[11]  H. Swanson,et al.  Age-related differences in learning disabled and skilled readers' working memory. , 2003, Journal of experimental child psychology.

[12]  Susan E. Gathercole,et al.  Working memory assessments at school entry as longitudinal predictors of National Curriculum attainment levels , 2003, Educational and Child Psychology.

[13]  E. Granholm,et al.  Substance use and withdrawal: Neuropsychological functioning over 8 years in youth , 2002, Journal of the International Neuropsychological Society.

[14]  V. Menon,et al.  Neural basis of protracted developmental changes in visuo-spatial working memory , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Russell Schachar,et al.  Working memory after traumatic brain injury in children , 2002, Annals of neurology.

[16]  M. D’Esposito,et al.  The Influence of Working-Memory Demand and Subject Performance on Prefrontal Cortical Activity , 2002, Journal of Cognitive Neuroscience.

[17]  Tim Shallice,et al.  Executive Function Profile of Children With Attention Deficit Hyperactivity Disorder , 2002, Developmental neuropsychology.

[18]  Hans Forssberg,et al.  Increased Brain Activity in Frontal and Parietal Cortex Underlies the Development of Visuospatial Working Memory Capacity during Childhood , 2002, Journal of Cognitive Neuroscience.

[19]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[20]  S S Kindermann,et al.  fMRI measurement of brain dysfunction in alcohol-dependent young women. , 2001, Alcoholism, clinical and experimental research.

[21]  A. Saykin,et al.  Brain activation on fMRI and verbal memory ability: Functional neuroanatomic correlates of CVLT performance , 2001, Journal of the International Neuropsychological Society.

[22]  B. Horwitz,et al.  Correlations between Reaction Time and Cerebral Blood Flow during Motor Preparation , 2000, NeuroImage.

[23]  Oliver Speck,et al.  Gender differences in the functional organization of the brain for working memory , 2000, Neuroreport.

[24]  S. Tapert,et al.  Substance dependence, family history of alcohol dependence and neuropsychological functioning in adolescence. , 2000, Addiction.

[25]  D. Shaffer,et al.  NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. , 2000, Journal of the American Academy of Child and Adolescent Psychiatry.

[26]  Christopher S. Monk,et al.  Functional neuroanatomy of spatial working memory in children. , 2000, Developmental psychology.

[27]  R. Cabeza,et al.  Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies , 2000, Journal of Cognitive Neuroscience.

[28]  R W Cox,et al.  Real‐time 3D image registration for functional MRI , 1999, Magnetic resonance in medicine.

[29]  S. Gathercole.  Cognitive approaches to the development of short-term memory , 1999, Trends in Cognitive Sciences.

[30]  A. Saykin,et al.  Brain activation during working memory 1 month after mild traumatic brain injury , 1999, Neurology.

[31]  S. Tapert,et al.  Neuropsychological correlates of adolescent substance abuse: Four-year outcomes , 1999, Journal of the International Neuropsychological Society.

[32]  Douglas C. Noll,et al.  A Developmental Functional MRI Study of Spatial Working Memory , 1999, NeuroImage.

[33]  R. Coppola,et al.  Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. , 1999, Cerebral cortex.

[34]  P. F. Jong.  Working Memory Deficits of Reading Disabled Children , 1998 .

[35]  L. Rapport,et al.  Viariability in Clinical Classification of Raw Test Scores Across Normative Data Sets , 1998 .

[36]  S. Tapert,et al.  Psychometric evaluation of the Customary Drinking and Drug Use Record (CDDR): a measure of adolescent alcohol and drug involvement. , 1998, Journal of studies on alcohol.

[37]  A. Thompson,et al.  Comparison of WAIS—R and WISC—III Scores with a Sample of 16-Year-Old Youth , 1998, Psychological reports.

[38]  C. Nelson,et al.  The functional emergence of prefrontally-guided working memory systems in four- to eight-year-old children , 1998, Neuropsychologia.

[39]  G J Hitch,et al.  Working memory and children's mental addition. , 1997, Journal of experimental child psychology.

[40]  Edward E. Smith,et al.  A Parametric Study of Prefrontal Cortex Involvement in Human Working Memory , 1996, NeuroImage.

[41]  J. Townsend,et al.  Attention coordination and anticipatory control. , 1997, International review of neurobiology.

[42]  M. Daneman,et al.  Working memory and language comprehension: A meta-analysis , 1996, Psychonomic bulletin & review.

[43]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[44]  Karl J. Friston,et al.  Movement‐Related effects in fMRI time‐series , 1996, Magnetic resonance in medicine.

[45]  J. Rice,et al.  Comparison of direct interview and family history diagnoses of alcohol dependence. , 1995, Alcoholism, clinical and experimental research.

[46]  Jonathan D. Cohen,et al.  Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold , 1995, Magnetic resonance in medicine.

[47]  J. Cohen,et al.  Spiral K‐space MR imaging of cortical activation , 1995, Journal of magnetic resonance imaging : JMRI.

[48]  P. Goldman-Rakic,et al.  Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[49]  L. Henry,et al.  Working memory span and phonological awareness tasks as predictors of early reading ability. , 1994, Journal of experimental child psychology.

[50]  R H Logie,et al.  Counting on working memory in arithmetic problem solving , 1994, Memory & cognition.

[51]  E C Wong,et al.  Processing strategies for time‐course data sets in functional mri of the human brain , 1993, Magnetic resonance in medicine.

[52]  Bob S. Hu,et al.  Fast Spiral Coronary Artery Imaging , 1992, Magnetic resonance in medicine.

[53]  Graham Hitch,et al.  The Development of Working Memory , 1992 .

[54]  Douglas C. Noll,et al.  Deblurring for non‐2D fourier transform magnetic resonance imaging , 1992, Magnetic resonance in medicine.

[55]  J. Talairach,et al.  Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging , 1988 .

[56]  S. Brown,et al.  Characteristics of relapse following adolescent substance abuse treatment. , 1989, Addictive behaviors.

[57]  Christie Golden,et al.  Stroop Color and Word Test: Manual for Clinical and Experimental Uses. , 1978 .

[58]  R. Reitan.  Validity of the Trail Making Test as an Indicator of Organic Brain Damage , 1958 .

[59]  D. Wechsler.  Manual for the Wechsler Adult Intelligence Scale. , 1955 .

[60]  P. Osterrieth.  Le test de copie d'une figure complexe , 1944 .