Neurobiological effects of intraventricular propionic acid in rats: Possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders

[1]  M. Grafe,et al.  Neuropathology of Propionic Acidemia: A Report of Two Patients With Basal Ganglia Lesions , 1995, Journal of child neurology.

[2]  W. Burnham.  Cortical and Limbic Kindling: Similarities and Differences , 1978 .

[3]  H. Savaş,et al.  Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism. , 2003, Clinica chimica acta; international journal of clinical chemistry.

[4]  M. Wajner,et al.  Effect of Propionic and Methylmalonic Acids on the in Vitro Phosphorylation of Intermediate Filaments from Cerebral Cortex of Rats During Development , 2003, Metabolic Brain Disease.

[5]  J. Crawley.  Designing mouse behavioral tasks relevant to autistic-like behaviors. , 2004, Mental retardation and developmental disabilities research reviews.

[6]  F. Besag.  Behavioral aspects of pediatric epilepsy syndromes , 2004, Epilepsy & Behavior.

[7]  T. Kemper,et al.  Hippocampus in autism: a Golgi analysis , 1995, Acta Neuropathologica.

[8]  G. Macfarlane,et al.  Short chain fatty acids in human large intestine, portal, hepatic and venous blood. , 1987, Gut.

[9]  E. Lock,et al.  Symposium overview: the role of glutathione in neuroprotection and neurotoxicity. , 1999, Toxicological sciences : an official journal of the Society of Toxicology.

[10]  R. Washabau,et al.  Effect of short-chain fatty acids on contraction of smooth muscle in the canine colon. , 2002, American journal of veterinary research.

[11]  Christian Giaume,et al.  Pathways of neuron-astrocyte interactions and their possible role in neuroprotection , 2001, European Archives of Psychiatry and Clinical Neuroscience.

[12]  I. Tannock,et al.  Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. , 1993, British Journal of Cancer.

[13]  M. Wajner,et al.  Ganglioside Alterations in the Central Nervous System of Rats Chronically Injected with Methylmalonic and Propionic Acids , 2002, Metabolic Brain Disease.

[14]  J. Piven,et al.  Structural and functional magnetic resonance imaging of autism , 2002, International Journal of Developmental Neuroscience.

[15]  R. Duelli,et al.  Correlation between local monocarboxylate transporter 1 (MCT1) and glucose transporter 1 (GLUT1) densities in the adult rat brain , 2004, Neuroscience Letters.

[16]  M. Wajner,et al.  Ascorbic acid prevents cognitive deficits caused by chronic administration of propionic acid to rats in the water maze , 2002, Pharmacology Biochemistry and Behavior.

[17]  M. Vacca,et al.  [3 H]-DA release evoked by low pH medium and internal H+ accumulation in rat hypothalamic synaptosomes: involvement of calcium ions , 2003, Neurochemistry International.

[18]  P. Decouflé,et al.  Prevalence of autism in a United States population: the Brick Township, New Jersey, investigation. , 2001, Pediatrics.

[19]  J. Sellin,et al.  Propionate-initiated changes in intracellular pH in rabbit colonocytes. , 1994, Gastroenterology.

[20]  P. Willner.  Animal models as simulations of depression. , 1991, Trends in pharmacological sciences.

[21]  E. Stadtman,et al.  Carbonyl assays for determination of oxidatively modified proteins. , 1994, Methods in enzymology.

[22]  R. Racine.  Modification of seizure activity by electrical stimulation: cortical areas. , 1975, Electroencephalography and clinical neurophysiology.

[23]  A. Richardson.  Omega-3 fatty acids in ADHD and related neurodevelopmental disorders , 2006, International review of psychiatry.

[24]  S. Fatemi,et al.  Levels of Bcl-2 and P53 Are Altered in Superior Frontal and Cerebellar Cortices of Autistic Subjects , 2003, Cellular and Molecular Neurobiology.

[25]  V. Pieribone,et al.  Midbrain serotonergic neurons are central pH chemoreceptors , 2003, Nature Neuroscience.

[26]  S. Felber,et al.  Magnetic resonance spectroscopy (MRS) in five patients with treated propionic acidemia , 2000, Journal of magnetic resonance imaging : JMRI.

[27]  J. Bronstein,et al.  Regulation of type-II calmodulin kinase: Functional implications , 1993, Brain Research Reviews.

[28]  J. F. White,et al.  Intestinal Pathophysiology in Autism , 2003, Experimental biology and medicine.

[29]  Marilyn Miller,et al.  Autism and Möbius sequence: an exploratory study of children in northeastern Brazil. , 2003, Arquivos de neuro-psiquiatria.

[30]  H. Jyonouchi,et al.  Innate Immunity Associated with Inflammatory Responses and Cytokine Production against Common Dietary Proteins in Patients with Autism Spectrum Disorder , 2002, Neuropsychobiology.

[31]  U. Bonnet,et al.  Intracellular pH modulates spontaneous and epileptiform bioelectric activity of hippocampal CA3-neurones , 2000, European Neuropsychopharmacology.

[32]  R. Putnam,et al.  Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones , 2002, Journal of Physiology.

[33]  K. Gale,et al.  Intracerebral injection of caspase-3 inhibitor prevents neuronal apoptosis after kainic acid-evoked status epilepticus. , 2000, Brain research. Molecular brain research.

[34]  R. Yuste,et al.  Extensive dye coupling between rat neocortical neurons during the period of circuit formation , 1993, Neuron.

[35]  J. O'Callaghan,et al.  Quantitative aspects of drug and toxicant-induced astrogliosis , 1995, Neurochemistry International.

[36]  R. Racine,et al.  Modification of seizure activity by electrical stimulation. II. Motor seizure. , 1972, Electroencephalography and clinical neurophysiology.

[37]  David W Gaylor,et al.  Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. , 2004, The American journal of clinical nutrition.

[38]  S. Zoroglu,et al.  Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism , 2004, European Archives of Psychiatry and Clinical Neuroscience.

[39]  W. B. Woodhurst,et al.  Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy , 1995, Neuroscience Letters.

[40]  F. Cicirata,et al.  Connexin expression in homotypic and heterotypic cell coupling in the developing cerebral cortex , 2002, The Journal of comparative neurology.

[41]  H. Takanaga,et al.  Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. , 1995, Biochemical and biophysical research communications.

[42]  S. Lyonnet,et al.  Sources of propionate in inborn errors of propionate metabolism. , 1990, Metabolism: clinical and experimental.

[43]  Roger D. Traub,et al.  The role of electrical signaling via gap junctions in the generation of fast network oscillations , 2003, Brain Research Bulletin.

[44]  E. Durigon,et al.  Prevalence of Clostridium spp. and Clostridium difficile in children with acute diarrhea in São Paulo city, Brazil. , 2003, Memorias do Instituto Oswaldo Cruz.

[45]  M. Wajner,et al.  Inhibition of Na+, K+-ATPase activity in rat striatum by the metabolites accumulated in Lesch–Nyhan disease , 2004, International Journal of Developmental Neuroscience.

[46]  Jareen Meinzen-Derr,et al.  Elevated cytokine levels in children with autism spectrum disorder , 2006, Journal of Neuroimmunology.

[47]  C. Barthélémy,et al.  Plasma fatty acid levels in autistic children. , 2001, Prostaglandins, leukotrienes, and essential fatty acids.

[48]  C. Pérez-Cerdá,et al.  Propionic acidemia: identification of twenty-four novel mutations in Europe and North America. , 2003, Molecular genetics and metabolism.

[49]  M. Atzori,et al.  Nitric oxide sensitive depolarization‐induced hyperpolarization: a possible role for gap junctions during development , 1998, The European journal of neuroscience.

[50]  P. Willner,et al.  The validity of animal models of depression , 2004, Psychopharmacology.

[51]  R. Dermietzel,et al.  Effects of cytokines on microglial phenotypes and astroglial coupling in an inflammatory coculture model , 2005, Glia.

[52]  K. Ikuta,et al.  Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[53]  R. Mitsui,et al.  Neural and non‐neural mediation of propionate‐induced contractile responses in the rat distal colon , 2005, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[54]  T. Otto,et al.  Altered Social Behavior in Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor-Deficient Mice , 2004, The Journal of Neuroscience.

[55]  E. Dere,et al.  Mice with astrocyte‐directed inactivation of connexin43 exhibit increased exploratory behaviour, impaired motor capacities, and changes in brain acetylcholine levels , 2003, The European journal of neuroscience.

[56]  W B Jakoby,et al.  Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. , 1974, The Journal of biological chemistry.

[57]  K. Nakanishi,et al.  Astrocytic gap junction blockage and neuronal Ca2+ oscillation in neuron-astrocyte cocultures in vitro , 1998, Neurochemistry International.

[58]  E. Benveniste.  Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis , 1997, Journal of Molecular Medicine.

[59]  B. Hall,et al.  Phylogenetic relationships among ascomycetes: evidence from an RNA polymerse II subunit. , 1999, Molecular biology and evolution.

[60]  B. Rörig,et al.  Intracellular acidification reduced gap junction coupling between immature rat neocortical pyramidal neurones. , 1996, The Journal of physiology.

[61]  W. Nyhan,et al.  Neurologic nonmetabolic presentation of propionic acidemia. , 1999, Archives of neurology.

[62]  M. E. Corcoran,et al.  Vasopressin and the kindling of seizures. , 1984, Life sciences.

[63]  D. Stumpf,et al.  The effect of malate on propionate mitochondrial toxicity. , 1991, Biochemical medicine and metabolic biology.

[64]  P. Rodier,et al.  The teratology of autism , 2005, International Journal of Developmental Neuroscience.

[65]  D. Cain.  Bidirectional transfer of electrical and carbachol kindling , 1983, Brain Research.

[66]  J. Papadimitriou,et al.  Gastrointestinal abnormalities in children with autistic disorder. , 1999, The Journal of pediatrics.

[67]  D. Rabier,et al.  Methylmalonic and propionic acidaemias: Management and outcome , 2005, Journal of Inherited Metabolic Disease.

[68]  S. Folstein,et al.  Genetics of austim: complex aetiology for a heterogeneous disorder , 2001, Nature Reviews Genetics.

[69]  M. E. Corcoran,et al.  Characteristics of dorsal and ventral striatal kindling in rats , 1992, Epilepsy Research.

[70]  C. Gillberg,et al.  A sensitive ELISA for glial fibrillary acidic protein: application in CSF of children , 1992, Journal of Neuroscience Methods.

[71]  Cuche,et al.  Short‐chain fatty acids present in the ileum inhibit fasting gastrointestinal motility in conscious pigs , 1999, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[72]  G. Kroemer,et al.  Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria , 2002, Cell Death and Differentiation.

[73]  P. Filipek,et al.  Relative Carnitine Deficiency in Autism , 2004, Journal of autism and developmental disorders.

[74]  R. Pontcharraud,et al.  Lactic acid-induced increase of extracellular dopamine measured by microdialysis in rat striatum: evidence for glutamatergic and oxidative mechanisms , 1999, Brain Research.

[75]  Holly Moore,et al.  A Role for Electrotonic Coupling in the Striatum in the Expression of Dopamine Receptor-mediated Stereotypies , 2002, Neuropsychopharmacology.

[76]  John L. Bradshaw,et al.  Autism and Asperger's disorder: Are they movement disorders involving the cerebellum and/or basal ganglia? , 2005, Brain Research Bulletin.

[77]  S. Folstein,et al.  An autosomal genomic screen for autism. Collaborative linkage study of autism. , 1999, American journal of medical genetics.

[78]  J. Dichgans,et al.  Enhanced episodic‐like memory and kindling epilepsy in a rat model of tuberous sclerosis , 2006, Journal of neurochemistry.

[79]  P. Calder,et al.  Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes. , 2003, Life sciences.

[80]  T. Wassink,et al.  The search for autism disease genes. , 2004, Mental retardation and developmental disabilities research reviews.

[81]  L. Peltonen,et al.  Genome-wide scan for loci of Asperger syndrome , 2004, Molecular Psychiatry.

[82]  E. Lock,et al.  Glutathione depletion in the liver and brain produced by 2-chloropropionic acid: relevance to cerebellar granule cell necrosis , 1996, Archives of Toxicology.

[83]  C. Vargas,et al.  Effect of Chemically Induced Propionic Acidemia on Neurobehavioral Development of Rats , 1999, Pharmacology Biochemistry and Behavior.

[84]  K P Ossenkopp,et al.  The measurement and integration of behavioral variables: aggregation and complexity as important issues. , 1985, Neurobehavioral toxicology and teratology.

[85]  K. Barron.  The microglial cell. A historical review , 1995, Journal of the Neurological Sciences.

[86]  A. Grace,et al.  Modulation of Cell Firing in the Nucleus Accumbens , 1999, Annals of the New York Academy of Sciences.

[87]  E. Brass,et al.  Effect of carnitine on propionate metabolism in the vitamin B-12--deficient rat. , 1989, The Journal of nutrition.

[88]  C. Vargas,et al.  Chronic administration of propionic acid reduces ganglioside N-acetylneuraminic acid concentration in cerebellum of young rats , 1998, Journal of the Neurological Sciences.

[89]  Wyatt H. Rivas,et al.  Prevalence of serum antibodies to caudate nucleus in autistic children , 2004, Neuroscience Letters.

[90]  Paul M. Thompson,et al.  White matter abnormalities in autism detected through transverse relaxation time imaging , 2006, NeuroImage.

[91]  R. A. Waniewski,et al.  Preferential Utilization of Acetate by Astrocytes Is Attributable to Transport , 1998, The Journal of Neuroscience.

[92]  E. Brass,et al.  Interactions of propionate and carnitine metabolism in isolated rat hepatocytes. , 1987, Metabolism: clinical and experimental.

[93]  J. Spiess,et al.  In vivo CREB phosphorylation mediated by dopamine and NMDA receptor activation in mouse hippocampus and caudate nucleus. , 2002, Brain research. Gene expression patterns.

[94]  J. Nerbonne,et al.  Substituted benzyl acetates: a new class of compounds that reduce gap junctional conductance by cytoplasmic acidification , 1984, The Journal of cell biology.

[95]  R. Tuchman,et al.  Epilepsy in autism , 2002, The Lancet Neurology.

[96]  M. Parmentier,et al.  Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation* , 2003, Journal of Biological Chemistry.

[97]  Eric Courchesne,et al.  Brain overgrowth in autism during a critical time in development: implications for frontal pyramidal neuron and interneuron development and connectivity , 2005, International Journal of Developmental Neuroscience.

[98]  K. Rajasekaran.  Seizure-induced oxidative stress in rat brain regions: blockade by nNOS inhibition , 2005, Pharmacology Biochemistry and Behavior.

[99]  J. Hörandel,et al.  COSMIC RAYS FROM THE KNEE TO THE SECOND , 2007 .

[100]  C. Lawler,et al.  Identifying environmental contributions to autism: provocative clues and false leads. , 2004, Mental retardation and developmental disabilities research reviews.

[101]  C. Duyckaerts,et al.  Tumor necrosis factor-alpha, microglia and astrocytes in AIDS dementia complex. , 1997, Acta neuropathologica.

[102]  Taizen Nakase,et al.  Gap junctions and neurological disorders of the central nervous system. , 2004, Biochimica et biophysica acta.

[103]  O. Ottersen,et al.  Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain , 2003, Neuroscience.

[104]  E. Ponomarev,et al.  Microglial cell activation and proliferation precedes the onset of CNS autoimmunity , 2005, Journal of neuroscience research.

[105]  A. Sitta,et al.  Inhibition of mitochondrial creatine kinase activity from rat cerebral cortex by methylmalonic acid , 2004, Neurochemistry International.

[106]  M. Ugarte,et al.  Qualitative and quantitative analysis of the effect of splicing mutations in propionic acidemia underlying non-severe phenotypes , 2004, Human Genetics.

[107]  P. Carlen,et al.  Changes in Neuronal Migration in Neocortex of Connexin43 Null Mutant Mice , 2003, Journal of neuropathology and experimental neurology.

[108]  R. Gerlai,et al.  Autism: a large unmet medical need and a complex research problem , 2003, Physiology & Behavior.

[109]  D. L. Coulter,et al.  Carnitine, valproate, and toxicity. , 1991, Journal of child neurology.

[110]  M. Wajner,et al.  Experimental hyperphenylalaninemia provokes oxidative stress in rat brain. , 2002, Biochimica et biophysica acta.

[111]  Haroun Shah,et al.  Gastrointestinal microflora studies in late-onset autism. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[112]  R. Beninger,et al.  Rotational Bias in Intact Rats Following Intrastriatal Injections of Dopaminergic Drugs , 1997, Pharmacology Biochemistry and Behavior.

[113]  B. Merinero,et al.  Genetic analysis of three genes causing isolated methylmalonic acidemia: identification of 21 novel allelic variants. , 2005, Molecular genetics and metabolism.

[114]  D. L. Coulter,et al.  Review Article: Carnitine, Valproate, and Toxicity , 1991 .

[115]  F. Zacchello,et al.  Clinical and biochemical approach to the neonate with a suspected inborn error of amino acid and organic acid metabolism. , 1999, Seminars in perinatology.

[116]  R. Neuman,et al.  Brain-Derived Neurotrophic Factor and Autoantibodies to Neural Antigens in Sera of Children with Autistic Spectrum Disorders, Landau-Kleffner Syndrome, and Epilepsy , 2006, Biological Psychiatry.

[117]  P. Carlen,et al.  Neurotransmitter Modulation of Gap Junctional Communication in the Rat Hippocampus , 1997, The European journal of neuroscience.

[118]  I. Carlberg,et al.  Glutathione reductase. , 1985, Methods in enzymology.

[119]  T. Kemper,et al.  Neuroanatomic observations of the brain in autism: a review and future directions , 2005, International Journal of Developmental Neuroscience.

[120]  R. Ebstein,et al.  Evidence for an association with the serotonin transporter promoter region polymorphism and autism. , 2001, American journal of medical genetics.

[121]  A. Zimmerman,et al.  Neuroglial activation and neuroinflammation in the brain of patients with autism , 2005, Annals of neurology.

[122]  E. Nestler,et al.  The many faces of CREB , 2005, Trends in Neurosciences.

[123]  M. Coppi,et al.  Propionate induces polymorphonuclear leukocyte activation and inhibits formylmethionyl-leucyl-phenylalanine-stimulated activation , 1992, Infection and immunity.

[124]  D. Cain.  Bidirectional transfer of intracerebrally administered pentylenetetrazol and electrical kindling , 1982, Pharmacology Biochemistry and Behavior.

[125]  A. Grace,et al.  Cortical afferents modulate striatal gap junction permeability via nitric oxide , 1996, Neuroscience.

[126]  L. Costa,et al.  Developmental neurotoxicity: do similar phenotypes indicate a common mode of action? A comparison of fetal alcohol syndrome, toluene embryopathy and maternal phenylketonuria. , 2002, Toxicology letters.

[127]  P. Rodier,et al.  Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism. , 2000, Neurotoxicology and teratology.

[128]  Stuart Johnson,et al.  An epidemic, toxin gene-variant strain of Clostridium difficile. , 2005, The New England journal of medicine.

[129]  W. Valentine,et al.  Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. , 1967, The Journal of laboratory and clinical medicine.

[130]  S. Finegold,et al.  Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children , 2004, Applied and Environmental Microbiology.

[131]  K. Unsicker,et al.  Regulation of gap junction communication by growth factors from non‐neural cells to astroglia: A brief review , 1998, Glia.

[132]  J. Pinel,et al.  Controlled demonstration of metrazol kindling , 1977, Pharmacology Biochemistry and Behavior.

[133]  O. Ottersen,et al.  Immunogold Cytochemistry Identifies Specialized Membrane Domains for Monocarboxylate Transport in the Central Nervous System , 2002, Neurochemical Research.

[134]  J. Velazquez,et al.  Gap Junctions and Neuronal Injury: Protectants or Executioners? , 2003, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[135]  B. Harris,et al.  Propionic acidemia: a neuropathology case report and review of prior cases. , 2009, Archives of pathology & laboratory medicine.

[136]  W. Buckel,et al.  On the mechanism of action of the antifungal agent propionate. , 2004, European journal of biochemistry.

[137]  P. Ozand,et al.  18Fluoro-2-deoxyglucose (18FDG) PET scan of the brain in propionic acidemia: clinical and MRI correlations , 1999, Brain and Development.

[138]  Stanley J. Watson,et al.  The rat brain in stereotaxic coordinates (2nd edn) by George Paxinos and Charles Watson, Academic Press, 1986. £40.00/$80.00 (264 pages) ISBN 012 547 6213 , 1987, Trends in Neurosciences.

[139]  J. Mandell,et al.  Transient neuronal but persistent astroglial activation of ERK/MAP kinase after focal brain injury in mice. , 2003, Journal of neurotrauma.

[140]  M. Mulvany,et al.  Short chain fatty acids dilate isolated human colonic resistance arteries. , 1990, Gut.

[141]  J. Renau‐Piqueras,et al.  Glia and fetal alcohol syndrome. , 2001, Neurotoxicology.

[142]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[143]  L. Goldsmith,et al.  What is the pathogenesis of acne? , 2005, Lancet.

[144]  A. Sabrá,et al.  Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children , 1998, The Lancet.

[145]  Eric Courchesne,et al.  Cerebral Lobes in Autism: Early Hyperplasia and Abnormal Age Effects , 2002, NeuroImage.

[146]  M. Mckinney,et al.  Indicators of glial activation and brain oxidative stress after intraventricular infusion of endotoxin. , 1998, Brain research. Molecular brain research.

[147]  J. Nowak,et al.  Retinal dopamine D1 and D2 receptors: Characterization by binding or pharmacological studies and physiological functions , 1990, Cellular and Molecular Neurobiology.

[148]  T. Iwanaga,et al.  Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine , 2006, Cell and Tissue Research.

[149]  T. Kielian,et al.  Effects of neuroinflammation on glia–glia gap junctional intercellular communication: a perspective , 2004, Neurochemistry International.

[150]  M. Wajner,et al.  Inhibition of Na+,K+‐ATPase from rat brain cortex by propionic acid , 1998, Neuroreport.

[151]  G. Gascon,et al.  Biotin-responsive basal ganglia disease: a novel entity. , 1998, Brain : a journal of neurology.

[152]  M. Mattson,et al.  Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders , 2002, NeuroMolecular Medicine.

[153]  R. Beninger,et al.  Brain sites of movement disorder: Genetic and environmental agents in neurodevelopmental perturbations , 2009, Neurotoxicity Research.

[154]  B. Bošković,et al.  Nitric Oxide (NO) and Convulsions Induced by Pentylenetetrazol , 2002, Annals of the New York Academy of Sciences.

[155]  J. Brian,et al.  Behavioral manifestations of autism in the first year of life , 2005, International Journal of Developmental Neuroscience.

[156]  G. Stoll,et al.  Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system. , 2002, Advances in experimental medicine and biology.

[157]  G. Karikas,et al.  Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy , 2001, Epilepsia.

[158]  C. Prasad,et al.  The importance of gut motility in the metabolic control of propionic acidemia. , 2004, The Journal of pediatrics.

[159]  C. Casal,et al.  Astrocytes enhance lipopolysaccharide‐induced nitric oxide production by microglial cells , 2002, The European journal of neuroscience.

[160]  Tonya Clark-Taylor,et al.  Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial beta-oxidation by long chain acyl-CoA dehydrogenase. , 2004, Medical hypotheses.

[161]  R. Mrak,et al.  Glial‐Neuronal Interactions in Alzheimer Disease: Progressive Association of IL‐1α+ Microglia and S100β+ Astrocytes with Neurofibrillary Tangle Stages , 1997, Journal of neuropathology and experimental neurology.

[162]  A. Brooks,et al.  Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: A potential animal model for schizophrenia and autism , 2005, Synapse.

[163]  E. Brass,et al.  Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain-length fatty acids. , 1988, The Biochemical journal.

[164]  C. Andres.  Molecular genetics and animal models in autistic disorder , 2002, Brain Research Bulletin.

[165]  A. Nógrádi,et al.  Up‐regulation of cerebral carbonic anhydrase by anoxic stress in piglets , 2003, Journal of neurochemistry.

[166]  P. Carlen,et al.  Modulation of gap junctional mechanisms during calcium-free induced field burst activity: a possible role for electrotonic coupling in epileptogenesis , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[167]  M. Kato,et al.  Increased Monoamine Concentration in the Brain and Blood of Fetal Thalidomide- and Valproic Acid–Exposed Rat: Putative Animal Models for Autism , 2002, Pediatric Research.

[168]  D. Geschwind,et al.  A genomewide screen for autism susceptibility loci. , 2001, American journal of human genetics.

[169]  Tom Benton,et al.  Eshkol-Wachman movement notation in diagnosis: the early detection of Asperger's syndrome. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[170]  D. Cain.  Kindling by repeated intraperitoneal or intracerebral injection of picrotoxin transfers to electrical kindling , 1987, Experimental Neurology.

[171]  S. González,et al.  Assessing survival of dairy propionibacteria in gastrointestinal conditions and adherence to intestinal epithelia. , 2004, Methods in molecular biology.

[172]  S. Folstein,et al.  An autosomal genomic screen for autism. , 1999, American journal of medical genetics.

[173]  B. Kerr,et al.  Fetal valproate syndrome and autism: additional evidence of an association , 2001, Developmental medicine and child neurology.

[174]  G. Svensäter,et al.  Acid formation in sucrose-exposed dental plaque in relation to caries incidence in schoolchildren , 2000, Clinical Oral Investigations.

[175]  G. Dawson,et al.  Defining the broader phenotype of autism: Genetic, brain, and behavioral perspectives , 2002, Development and Psychopathology.

[176]  W. Brown,et al.  Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin--the antioxidant proteins. , 2004, Life sciences.

[177]  T. Dawson,et al.  Nitric oxide neurotoxicity , 1996, Journal of Chemical Neuroanatomy.

[178]  L. Berliner,et al.  Magnetic resonance and biochemical studies during pentylenetetrazole-kindling development: The relationship between nitric oxide, neuronal nitric oxide synthase and seizures , 2004, Neuroscience.

[179]  B. Sutor,et al.  Dye coupling between pyramidal neurons in developing rat prefrontal and frontal cortex is reduced by protein kinase A activation and dopamine , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[180]  C. Duyckaerts,et al.  Tumor necrosis factor-α, microglia and astrocytes in AIDS dementia complex , 1997, Acta Neuropathologica.

[181]  M. Wajner,et al.  Methylmalonic and propionic acids increase the in vitro incorporation of 32 P into cytoskeletal proteins from cerebral cortex of young rats through NMDA glutamate receptors , 2000, Brain Research.

[182]  M. Wajner,et al.  The role of oxidative damage in the neuropathology of organic acidurias: Insights from animal studies , 2004, Journal of Inherited Metabolic Disease.

[183]  P. Mander,et al.  Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration , 2002, Neuroscience.

[184]  R. Niederman,et al.  Alteration of cytoplasmic Ca2+ in resting and stimulated human neutrophils by short-chain carboxylic acids at neutral pH , 1992, Infection and immunity.

[185]  V. Calabrese,et al.  Formation of propionate after short-term ethanol treatment and its interaction with the carnitine pool in rat. , 1999, Alcohol.

[186]  B. McClane,et al.  The clostridia: molecular biology and pathogenesis , 1997 .

[187]  T. Mes,et al.  Phylogenetic relationships in , 1997 .

[188]  W. Boyes,et al.  Prolonged neurobehavioral and visual effects of short-term exposure to 3,3'-iminodipropionitrile (IDPN) in rats. , 1993, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[189]  B. Mannervik,et al.  [59] Glutathione reductase , 1985 .

[190]  M. Baumgartner,et al.  Propionic acidemia: unusual course with late onset and fatal outcome. , 2004, Metabolism: clinical and experimental.

[191]  J. Anders.  Lactic acid inhibition of gap junctional intercellular communication in in vitro astrocytes as measured by fluorescence recovery after laser photobleaching , 1988, Glia.

[192]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[193]  L. Freund,et al.  Behavior phenotype in the RSH/Smith-Lemli-Opitz syndrome. , 2001, American journal of medical genetics.

[194]  Lalit,et al.  Etiology of infantile autism: a review of recent advances in genetic and neurobiological research. , 1999, Journal of psychiatry & neuroscience : JPN.