Axillary Dissection: An Obsolete Operation?

Abstract: Our concept of the role of axillary dissection in breast cancer management continues to change. The decreased morbidity of breast conserving therapy has focused more attention on the sequelae of axillary dissection. In addition, the increasingly frequent identification of small breast cancers at low risk for nodal metastases means that fewer patients benefit from axillary dissection. This article reviews the morbidity of axillary dissection, the risk of nodal metastases in a variety of patient groups, and the frequency with which nodal metastases alter the use of adjuvant therapy.

[1]  Donald L. Morton,et al.  Lymphatic Mapping and Sentinel Lymphadenectomy for Breast Cancer , 1994, Annals of surgery.

[2]  D. Weaver,et al.  Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe. , 1993, Surgical oncology.

[3]  R. Gelber,et al.  Meeting highlights: adjuvant therapy for primary breast cancer. , 1992, Journal of the National Cancer Institute.

[4]  S. Huchcroft,et al.  Arm function after axillary dissection for breast cancer: A pilot study to provide parameter estimates , 1992, Journal of surgical oncology.

[5]  Early Breast Cancer Trialists' Collaborative Group Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy 133 randomised trials involving 31 000 recurrences and 24 000 deaths among 75 000 women , 1992, The Lancet.

[6]  D. Morton,et al.  The impact of microinvasion on axillary node metastases and survival in patients with intraductal breast cancer. , 1990, Archives of surgery.

[7]  M. Silverstein,et al.  Intraductal carcinoma of the breast (208 cases): Clinical factors influencing treatment choice , 1990, Cancer.

[8]  C. Carter,et al.  Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases , 1989, Cancer.

[9]  J. Coindre,et al.  Micrometastases to axillary lymph nodes from carcinoma of breast: detection by immunohistochemistry and prognostic significance. , 1987, British Journal of Cancer.

[10]  T. Nemoto,et al.  Intraductal Carcinoma: Analysis of Presentation, Pathologic Findings, and Outcome of Disease , 1986 .

[11]  D. Gersell,et al.  Tubular carcinoma of the breast: Clinical and pathological observations concerning 135 cases , 1982, The American journal of surgical pathology.

[12]  L. Baker,et al.  Breast cancer detection demonstration project: Five‐year summary report , 1982, CA: a cancer journal for clinicians.

[13]  G. Peters,et al.  Tubular carcinoma of the breast. Clinical pathologic correlations based on 100 cases. , 1981, Annals of surgery.

[14]  G. Murphy,et al.  Noninvasive Breast Carcinoma: Results of a National Survey by the American College of Surgeons , 1980, Annals of surgery.

[15]  J. Nevin,et al.  Minimal breast carcinoma. , 1980, American journal of surgery.

[16]  R. E. Snyder,et al.  Prospective study of non‐infiltrating carcinoma of the breast , 1977, Cancer.

[17]  J. Pickren Significance of occult metastases. A study of breast cancer , 1961, Cancer.

[18]  M. Silverstein,et al.  Predictors of axillary lymph node metastases in patients with T1 breast carcinoma , 1997, Cancer.

[19]  J. Seidman,et al.  Relationship of the size of the invasive component of the primary breast carcinoma to axillary lymph node metastasis , 1995, Cancer.

[20]  Early Breast Cancer Trialists' Collaborative Group Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Early Breast Cancer Trialists' Collaborative Group. , 1992, Lancet.

[21]  I. Tannock,et al.  How American oncologists treat breast cancer: an assessment of the influence of clinical trials. , 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.