Resistance to airflow in patients with diffuse interstitial lung disease.

Lung elastic recoil and maximal expiratory flow-volume relationships were determined in 11 patients with evidence of diffuse interstitial lung disease and 9 normal control subjects. Elastic recoil was increased in all of the patients. For any given driving pressure, the maximal expiratory flow and upstream conductance were less than normal in most patients. The pressure-volume and pressure-flow characteristics of the lung improved after corticosteroid therapy in 2 patients with acute symptoms but were little affected in the one patient with long-standing symptoms. The data indicated increased resistance to airflow in the small airways of the patients.

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