Kaempferol is an estrogen‐related receptor α and γ inverse agonist

PGC‐1 alpha (uniprotkb:Q9UBK2) and ERR gamma (uniprotkb: P62508) bind (MI:0407) by surface plasmon resonance (MI:0107)

[1]  W. Stevens,et al.  Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha. , 2004, Journal of medicinal chemistry.

[2]  D. Knutti,et al.  The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). , 2003, The Journal of biological chemistry.

[3]  V. Giguère,et al.  4-Hydroxytamoxifen Is an Isoform-Specific Inhibitor of Orphan Estrogen-Receptor-Related (ERR) Nuclear Receptors β and γ. , 2001, Endocrinology.

[4]  J. Rossant,et al.  Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. , 2001, Genes & development.

[5]  N. Saarinen,et al.  Dietary phytoestrogens and their role in hormonally dependent disease. , 1998, Toxicology letters.

[6]  V. Giguère,et al.  Orphan nuclear receptors: from gene to function. , 1999 .

[7]  A. Kralli,et al.  PGC-1, a versatile coactivator , 2001, Trends in Endocrinology & Metabolism.

[8]  M. Olszewska.  Separation of quercetin, sexangularetin, kaempferol and isorhamnetin for simultaneous HPLC determination of flavonoid aglycones in inflorescences, leaves and fruits of three Sorbus species. , 2008, Journal of pharmaceutical and biomedical analysis.

[9]  H. Ciolino,et al.  Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. , 1999, The Biochemical journal.

[10]  Daniel P. Kelly,et al.  PGC-1α Coactivates the Cardiac-enriched Nuclear Receptors ERRα and γ via Novel Leucine-rich Interaction Interfaces , 2002 .

[11]  B. M. Forman,et al.  Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma. , 2005, Bioorganic & medicinal chemistry letters.

[12]  Daniel P. Kelly,et al.  PGC-1α Coactivates PDK4 Gene Expression via the Orphan Nuclear Receptor ERRα: a Mechanism for Transcriptional Control of Muscle Glucose Metabolism , 2005, Molecular and Cellular Biology.

[13]  J. Huss,et al.  Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. , 2002, The Journal of biological chemistry.

[14]  J. Ross,et al.  Dietary flavonoids: bioavailability, metabolic effects, and safety. , 2002, Annual review of nutrition.

[15]  S. Apers,et al.  Phytoestrogens: Recent Developments , 2003, Planta medica.

[16]  R. Evans,et al.  The RXR heterodimers and orphan receptors , 1995, Cell.

[17]  Q. Yao,et al.  Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. , 2008, The Journal of surgical research.

[18]  V. Giguère,et al.  PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. , 2005, Molecular and cellular biology.

[19]  V. Giguère,et al.  4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors beta and gamma. , 2001, Endocrinology.

[20]  D. McDonnell,et al.  Estrogen-related receptor a as a therapeutic target in cancer , 2006 .

[21]  Anastasia Kralli,et al.  The Transcriptional Coactivator PGC-1 Regulates the Expression and Activity of the Orphan Nuclear Receptor Estrogen-Related Receptor α (ERRα)* , 2003, The Journal of Biological Chemistry.

[22]  Ke Ma,et al.  Estrogen-related Receptors Stimulate Pyruvate Dehydrogenase Kinase Isoform 4 Gene Expression* , 2006, Journal of Biological Chemistry.

[23]  Benita S Katzenellenbogen,et al.  Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrogen receptor beta - regulation by selective estrogen receptor modulators and importance in breast cancer , 2000, Breast Cancer Research.

[24]  Daniel P. Kelly,et al.  Peroxisome Proliferator-activated Receptor Coactivator-1α (PGC-1α) Coactivates the Cardiac-enriched Nuclear Receptors Estrogen-related Receptor-α and -γ , 2002, The Journal of Biological Chemistry.

[25]  V. Giguère.  Transcriptional control of energy homeostasis by the estrogen-related receptors. , 2008, Endocrine reviews.

[26]  S. Sahu,et al.  Kaempferol-induced nuclear DNA damage and lipid peroxidation. , 1994, Cancer letters.

[27]  J. Lehmann,et al.  4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ , 2001, Proceedings of the National Academy of Sciences of the United States of America.