The Treatment of Idiopathic Sudden Sensorineural Hearing Loss Using Pulse Therapy: A Prospective, Randomized, Double‐Blind Clinical Trial

Objectives: The etiology and treatment of idiopathic sudden sensorineural hearing loss (ISSHL) is still unclear. The anti‐inflammatory effect of corticosteroids is thought to play an important part in the recovery from ISSHL. We aimed to determine whether a more powerful anti‐inflammatory technique using pulse therapy is effective in the treatment of ISSHL.

[1]  F. Akdaş,et al.  Idiopathic sudden sensorineural hearing loss , 2006 .

[2]  R. Stokroos,et al.  Treatment of Idiopathic Sudden Sensorineural Hearing Loss with Antiviral Therapy: A Prospective, Randomized, Double-Blind Clinical Trial , 2003, The Annals of otology, rhinology, and laryngology.

[3]  W. R. Cannon,et al.  Whipple's disease, genomics, and drug therapy , 2003, The Lancet.

[4]  M. Suckfüll Fibrinogen and LDL apheresis in treatment of sudden hearing loss: a randomised multicentre trial , 2002, The Lancet.

[5]  R. Ramírez‐Camacho,et al.  Sudden Sensorineural Hearing Loss: Supporting the Immunologic Theory , 2002, The Annals of otology, rhinology, and laryngology.

[6]  J. G. García Berrocal,et al.  Immune response and immunopathology of the inner ear: an update , 2000, The Journal of Laryngology & Otology.

[7]  D. Uges,et al.  Pharmacokinetics of high-dose oral and intravenous dexamethasone. , 1999, Therapeutic drug monitoring.

[8]  A. Mark,et al.  Sudden hearing loss: frequency of abnormal findings on contrast-enhanced MR studies. , 1998, AJNR. American journal of neuroradiology.

[9]  J. Roujeau,et al.  Pulse glucocorticoid therapy. The 'big shot' revisited. , 1996, Archives of dermatology.

[10]  D. Boumpas,et al.  Glucocorticoid Therapy for Immune-Mediated Diseases: Basic and Clinical Correlates , 1993, Annals of Internal Medicine.

[11]  F. Byl,et al.  Audiometric Comparison of Lassa Fever Hearing Loss and Idiopathic Sudden Hearing Loss: Evidence for Viral Cause , 1992, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[12]  Mattox De,et al.  Idiopathic sudden sensorineural hearing loss. , 1989, The American journal of otology.

[13]  A. Ryan,et al.  Immunobiology of the inner ear. , 1984, American journal of otolaryngology.

[14]  R. Veltri,et al.  Viral and Epidemiologic Studies of Idiopathic Sudden Hearing Loss , 1983, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[15]  F. Byl,et al.  The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. , 1980, Archives of otolaryngology.

[16]  F. B. Simmons,et al.  Natural History of Sudden Sensorineural Hearing Loss , 1977, The Annals of otology, rhinology, and laryngology.

[17]  H. Schuknecht,et al.  The pathology of sudden deafness. , 1973, Acta oto-laryngologica.