The interaction of hepatic lipid and glucose metabolism in liver diseases.

[1]  Wen Li,et al.  Double antioxidant activities of rosiglitazone against high glucose-induced oxidative stress in hepatocyte. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.

[2]  S. Sookoian,et al.  Cyclooxygenase inhibition Up‐regulates liver carnitine palmitoyltransferase 1A expression and improves fatty liver , 2011, Hepatology.

[3]  Lee H. Dicker,et al.  Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity , 2011, Nature.

[4]  H. Petry,et al.  Molecular therapy for obesity and diabetes based on a long‐term increase in hepatic fatty‐acid oxidation , 2011, Hepatology.

[5]  Roberto Conti,et al.  Selective Reversible Inhibition of Liver Carnitine Palmitoyl-Transferase 1 by Teglicar Reduces Gluconeogenesis and Improves Glucose Homeostasis , 2011, Diabetes.

[6]  J. Ertle,et al.  Nonalcoholic Fatty Liver Disease progresses to HCC in the absence of apparent Cirrhosis , 2011 .

[7]  R. Moreau,et al.  Autophagy in liver diseases. , 2010, Journal of hepatology.

[8]  Jian-min Wu,et al.  Evidence of aberrant lipid metabolism in hepatitis C and hepatocellular carcinoma. , 2010, HPB : the official journal of the International Hepato Pancreato Biliary Association.

[9]  Junji Furuse,et al.  The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective. , 2010, The oncologist.

[10]  A. Kahraman,et al.  Obesity Affects the Liver – The Link between Adipocytes and Hepatocytes , 2010, Digestion.

[11]  A. Feldstein,et al.  Novel Insights into the Pathophysiology of Nonalcoholic Fatty Liver Disease , 2010, Seminars in liver disease.

[12]  C. Trautwein,et al.  Cytokeratin 18-based modification of the MELD score improves prediction of spontaneous survival after acute liver injury. , 2010, Journal of hepatology.

[13]  P. Berk,et al.  Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice. , 2010, American journal of physiology. Gastrointestinal and liver physiology.

[14]  B. Neuschwander‐Tetri.  Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites , 2010, Hepatology.

[15]  D. Savage,et al.  Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance , 2010, Current opinion in lipidology.

[16]  F. Anania,et al.  Adiponectin activation of AMPK disrupts leptin‐mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS‐3) , 2010, Journal of cellular biochemistry.

[17]  M. Czaja,et al.  Macroautophagy and chaperone‐mediated autophagy are required for hepatocyte resistance to oxidant stress , 2010, Hepatology.

[18]  G. Yoon,et al.  Roles of GSK3 in metabolic shift toward abnormal anabolism in cell senescence , 2010, Annals of the New York Academy of Sciences.

[19]  K. Petersen,et al.  Lipid-induced insulin resistance: unravelling the mechanism , 2010, The Lancet.

[20]  Ping Li,et al.  Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. , 2010, Cell metabolism.

[21]  K. Moore,et al.  Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice. , 2010, Gastroenterology.

[22]  S. Soyal,et al.  Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans , 2010, Diabetologia.

[23]  F. Anania,et al.  Glucagon‐like peptide‐1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway , 2010, Hepatology.

[24]  M. Czaja.  Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implications. , 2010, American journal of physiology. Cell physiology.

[25]  K. Struhl,et al.  A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. , 2010, Cancer cell.

[26]  Chang Hwa Jung,et al.  mTOR regulation of autophagy , 2010, FEBS letters.

[27]  Lixin Sun,et al.  Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via Gαi-protein-coupled receptors and the AKT pathway[S] , 2010, Journal of Lipid Research.

[28]  G. Hotamisligil,et al.  Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease , 2010, Cell.

[29]  C. Montoliu,et al.  Relationship between insulin resistance, inflammation and liver cell apoptosis in patients with severe obesity , 2010, Diabetes/metabolism research and reviews.

[30]  Karthikeyan Chandrasekaran,et al.  Apoptosis in HepG2 cells exposed to high glucose. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.

[31]  Shijie Li,et al.  Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis , 2010, Proceedings of the National Academy of Sciences.

[32]  A. Craxì,et al.  Hepatocellular carcinoma and non-alcoholic fatty liver disease: from a clinical to a molecular association. , 2010, Current pharmaceutical design.

[33]  P. D. de Groot,et al.  Profiling of promoter occupancy by PPARα in human hepatoma cells via ChIP-chip analysis , 2010, Nucleic acids research.

[34]  Jun Hee Lee,et al.  Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression , 2010, Cell.

[35]  A. Kahraman,et al.  Apoptosis is associated with CD36/fatty acid translocase upregulation in non‐alcoholic steatohepatitis , 2009, Liver international : official journal of the International Association for the Study of the Liver.

[36]  F. He,et al.  Effects of farnesoid X receptor on the expression of the fatty acid synthetase and hepatic lipase , 2010, Molecular Biology Reports.

[37]  C. Hellerbrand,et al.  GLUT1 as a therapeutic target in hepatocellular carcinoma , 2009, Expert opinion on therapeutic targets.

[38]  T. Tuomi,et al.  Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY) , 2009, Diabetes Care.

[39]  S. Watkins,et al.  Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis , 2009, Nature Medicine.

[40]  M. Fessler,et al.  Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome , 2009, Current opinion in lipidology.

[41]  A. Feldstein,et al.  Cytokeratin‐18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study , 2009, Hepatology.

[42]  Hui-yu Liu,et al.  Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia , 2009, The Journal of Biological Chemistry.

[43]  J. Graff,et al.  Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure , 2009, Diabetes.

[44]  John Turk,et al.  Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver , 2009, Cell.

[45]  Feng Zhang,et al.  Adiponectin deficiency impairs liver regeneration through attenuating STAT3 phosphorylation in mice , 2009, Laboratory Investigation.

[46]  J. Girard,et al.  Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids. , 2009, The Biochemical journal.

[47]  F. Gonzalez,et al.  Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress. , 2009, Journal of hepatology.

[48]  R. Silverstein,et al.  CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior , 2009, Science Signaling.

[49]  S. Luquet,et al.  GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. , 2009, The Journal of clinical investigation.

[50]  Matteo Ricchi,et al.  Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes , 2009, Journal of gastroenterology and hepatology.

[51]  C. Nolan,et al.  Lipotoxicity: Why do saturated fatty acids cause and monounsaturates protect against it? , 2009, Journal of gastroenterology and hepatology.

[52]  Keiji Tanaka,et al.  The MAP1-LC3 conjugation system is involved in lipid droplet formation. , 2009, Biochemical and biophysical research communications.

[53]  M. le Gall,et al.  GLUT2 mutations, translocation, and receptor function in diet sugar managing. , 2009, American journal of physiology. Endocrinology and metabolism.

[54]  M. Czaja,et al.  Autophagy regulates lipid metabolism , 2009, Nature.

[55]  C. Kahn,et al.  Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFκB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance , 2009, Diabetologia.

[56]  J. Górski,et al.  Differential effects of in vivo PPAR alpha and gamma activation on fatty acid transport proteins expression and lipid content in rat liver. , 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[57]  Jihyun Song,et al.  Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance. , 2009, Cellular signalling.

[58]  J. Graff,et al.  Atf 4 Regulates Obesity , Glucose Homeostasis , and Energy Expenditure , 2009 .

[59]  M. Katze,et al.  UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. , 2008, Developmental cell.

[60]  Derek Y. Chiang,et al.  Pivotal role of mTOR signaling in hepatocellular carcinoma. , 2008, Gastroenterology.

[61]  J. Girard,et al.  The role of the lipogenic pathway in the development of hepatic steatosis. , 2008, Diabetes & metabolism.

[62]  P. Berk.  Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome , 2008, Hepatology.

[63]  A. Sanyal,et al.  Abnormalities of lipid metabolism in nonalcoholic fatty liver disease. , 2008, Seminars in liver disease.

[64]  Claudio R. Santos,et al.  SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth , 2008, Cell metabolism.

[65]  L. Agius.  Glucokinase and molecular aspects of liver glycogen metabolism. , 2008, The Biochemical journal.

[66]  Philippe Giral,et al.  Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. , 2008, Gastroenterology.

[67]  M. Diez,et al.  Liver lipid metabolism. , 2008, Journal of animal physiology and animal nutrition.

[68]  R. Hanson,et al.  Born to run; the story of the PEPCK-Cmus mouse. , 2008, Biochimie.

[69]  J. Muntané,et al.  Low doses of insulin-like growth factor-I induce mitochondrial protection in aging rats. , 2008, Endocrinology.

[70]  J. Girard,et al.  Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. , 2008, The Journal of clinical investigation.

[71]  K. Koike,et al.  PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. , 2008, The Journal of clinical investigation.

[72]  Kun Wook Chung,et al.  Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytess⃞s⃞ The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of three figures. Published, JLR Papers in Press, October 18, 2007. , 2008, Journal of Lipid Research.

[73]  Margaret F. Gregor,et al.  Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease Published, JLR Papers in Press, May 9, 2007. , 2007, Journal of Lipid Research.

[74]  K. Kotoh,et al.  Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. , 2007, International journal of molecular medicine.

[75]  S. McCall,et al.  Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis , 2007, Hepatology.

[76]  N. Sato.  Central role of mitochondria in metabolic regulation of liver pathophysiology , 2007, Journal of gastroenterology and hepatology.

[77]  H. Yoshimatsu,et al.  TNF-α Induces Hepatic Steatosis in Mice by Enhancing Gene Expression of Sterol Regulatory Element Binding Protein-1c (SREBP-1c) , 2007, Experimental biology and medicine.

[78]  C. Magnan,et al.  Free fatty acids and insulin resistance , 2007, Current opinion in clinical nutrition and metabolic care.

[79]  E. Bugianesi,et al.  Non-alcoholic steatohepatitis and cancer. , 2007, Clinics in liver disease.

[80]  C. Trautwein,et al.  Bile acids are “homeotrophic” sensors of the functional hepatic capacity and regulate adaptive growth during liver regeneration , 2007, Hepatology.

[81]  G. Ramadori,et al.  Carbohydrate metabolism and the liver: actual aspects from physiology and disease. , 2007, Zeitschrift fur Gastroenterologie.

[82]  Margaret F. Gregor,et al.  Adipocyte stress: the endoplasmic reticulum and metabolic disease , 2007 .

[83]  G. Hotamisligil,et al.  Inflammation and metabolic disorders , 2006, Nature.

[84]  R. Parton,et al.  Caveolin-1 Is Essential for Liver Regeneration , 2006, Science.

[85]  J. Girard,et al.  Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice , 2006, Diabetes.

[86]  P. Finn,et al.  Proteolytic and lipolytic responses to starvation. , 2006, Nutrition.

[87]  C. Kahn,et al.  Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. , 2006, Cell metabolism.

[88]  D. Moore,et al.  Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration , 2006, Science.

[89]  H. Lodish,et al.  Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. , 2006, Gastroenterology.

[90]  R. Gimeno,et al.  Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis. , 2006, Gastroenterology.

[91]  P. Malfertheiner,et al.  Troglitazone inhibits tumor growth in hepatocellular carcinoma in vitro and in vivo , 2006, Hepatology.

[92]  P. Arner.  Human fat cell lipolysis: biochemistry, regulation and clinical role. , 2005, Best practice & research. Clinical endocrinology & metabolism.

[93]  S. Tilghman,et al.  Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism , 2005, Nutrition & metabolism.

[94]  O. Erel,et al.  Measurement of the total antioxidant response using a novel automated method in subjects with nonalcoholic steatohepatitis , 2005, BMC gastroenterology.

[95]  G. Gibbons,et al.  A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver. , 2005, The Biochemical journal.

[96]  S. Sanderson,et al.  The natural history of nonalcoholic fatty liver disease: a population-based cohort study. , 2005, Gastroenterology.

[97]  B. Schreiber,et al.  PPARγ2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes , 2005 .

[98]  J. Jessurun,et al.  Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. , 2005, The Journal of clinical investigation.

[99]  I. Shimomura,et al.  Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease. , 2005, The Journal of clinical investigation.

[100]  R O Morgan,et al.  Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study , 2005, Gut.

[101]  R. Savkur,et al.  Regulation of carbohydrate metabolism by the farnesoid X receptor. , 2005, Endocrinology.

[102]  J. Girard,et al.  Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. , 2005, Biochimie.

[103]  E. Parks,et al.  Temporal pattern of de novo lipogenesis in the postprandial state in healthy men. , 2005, The American journal of clinical nutrition.

[104]  P. Berk,et al.  Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings. , 2005, Transactions of the American Clinical and Climatological Association.

[105]  B. Schreiber,et al.  PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. , 2005, American journal of physiology. Endocrinology and metabolism.

[106]  H. Tilg,et al.  Adiponectin and its receptors in non-alcoholic steatohepatitis , 2004, Gut.

[107]  Jonathan C. Cohen,et al.  Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity , 2004, Hepatology.

[108]  R. Gottlieb.  Autophagy in Health and Disease , 2004, Science.

[109]  G. Gores,et al.  Free fatty acids promote hepatic lipotoxicity by stimulating TNF‐α expression via a lysosomal pathway , 2004 .

[110]  G. Gores,et al.  O0040 FREE FATTY ACIDS PROMOTE HEPATIC LIPOTOXICITY BY STIMULATING TNF‐ALPHA EXPRESSION VIA A LYSOSOMAL PATHWAY , 2004, Journal of Pediatric Gastroenterology and Nutrition.

[111]  J. Grippo,et al.  Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. , 2004, American journal of physiology. Gastrointestinal and liver physiology.

[112]  R. Coleman,et al.  Enzymes of triacylglycerol synthesis and their regulation. , 2004, Progress in lipid research.

[113]  Govind Bhagat,et al.  Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. , 2003, The Journal of clinical investigation.

[114]  G. Gores,et al.  Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. , 2003, Journal of hepatology.

[115]  D. Scheuner,et al.  Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses , 2003, Molecular and Cellular Biology.

[116]  G. Gores,et al.  Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. , 2003, Gastroenterology.

[117]  Bruce M. Spiegelman,et al.  Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction , 2003, Nature.

[118]  Michael J Thun,et al.  Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. , 2003, The New England journal of medicine.

[119]  Jerry Donovan,et al.  Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. , 2003, Nature.

[120]  D. Scheuner,et al.  Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. , 2003, Molecular and cellular biology.

[121]  R. Eckel,et al.  Lipoprotein lipase : genetics , lipid uptake , and regulation , 2002 .

[122]  P. Roach,et al.  Glycogen and its metabolism. , 2002, Current molecular medicine.

[123]  J. Maher.  Alcoholic steatosis and steatohepatitis. , 2002, Seminars in gastrointestinal disease.

[124]  Janardan K. Reddy,et al.  III. Peroxisomal β-oxidation, PPARα, and steatohepatitis , 2001 .

[125]  J. Crespo,et al.  Gene expression of tumor necrosis factor α and TNF‐receptors, p55 and p75, in nonalcoholic steatohepatitis patients , 2001 .

[126]  I. Leclercq,et al.  Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[127]  J. Clore,et al.  Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. , 2001, Gastroenterology.

[128]  J K Reddy,et al.  Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[129]  J. Auwerx,et al.  The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. , 2000, Genomics.

[130]  K. Kim,et al.  Regulation of the fatty acid synthase promoter by insulin. , 2000, The Journal of nutrition.

[131]  Stephen P. Miller,et al.  Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype. , 1999, Diabetes.

[132]  F. Hegardt.  Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. , 1999, The Biochemical journal.

[133]  G. Gerber,et al.  Identification of caveolin-1 as a fatty acid binding protein. , 1999, Biochemical and biophysical research communications.

[134]  J. McGarry,et al.  The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. , 1997, European journal of biochemistry.

[135]  D. Stump,et al.  Mitochondrial Aspartate Aminotransferase Expressed on the Surface of 3T3-L1 Adipocytes Mediates Saturable Fatty Acid Uptake , 1995, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[136]  F. Bosch,et al.  Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[137]  P. Grimaldi,et al.  Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. , 1993, The Journal of biological chemistry.

[138]  D. Stump,et al.  Adipocyte differentiation of 3T3-L1 cells involves augmented expression of a 43-kDa plasma membrane fatty acid-binding protein. , 1992, The Journal of biological chemistry.

[139]  A. Lehninger.  Principles of Biochemistry , 1984 .