Cyclooxygenase-2: regulation and relevance in inflammation.

[1]  J. Vane,et al.  Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[2]  M. Rosa,et al.  Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774 , 1992, British journal of pharmacology.

[3]  B. Varnum,et al.  TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. , 1991, The Journal of biological chemistry.

[4]  R. Irvine.  How is the level of free arachidonic acid controlled in mammalian cells? , 1982, The Biochemical journal.

[5]  L. Solomon,et al.  Prostaglandin on cutaneous vasculature. , 1968, The Journal of investigative dermatology.

[6]  M. Holtzman,et al.  Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells. , 1992, The Journal of biological chemistry.

[7]  M. Greaves,et al.  Irradiation of human skin by short wavelength ultraviolet radiation (100--290 nm) (u.v.C): increased concentrations of arachidonic acid and prostaglandines E2 and F2alpha. , 1978, British journal of clinical pharmacology.

[8]  M. Currie,et al.  Nitric oxide activates cyclooxygenase enzymes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[9]  F. Murad,et al.  Endothelial cells have a particulate enzyme system responsible for EDRF formation: measurement by vascular relaxation. , 1991, Biochemical and biophysical research communications.

[10]  T. Ogihara,et al.  Nitric oxide mediates interleukin-1-induced prostaglandin E2 production by vascular smooth muscle cells. , 1993, Biochemical and biophysical research communications.

[11]  T. Williams,et al.  Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration. , 1986, The American journal of pathology.

[12]  T. Williams,et al.  Evidence for sensory nerve involvement in cutaneous reactive hyperemia in humans. , 1993, Circulation research.

[13]  E. Dennis.  Diversity of group types, regulation, and function of phospholipase A2. , 1994, The Journal of biological chemistry.

[14]  C. Thiemermann,et al.  Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[15]  P. Ward,et al.  Suppression by prostaglandin E1 of vascular permeability induced by vasoactive inflammatory mediators. , 1980, Journal of immunology.

[16]  T. Billiar,et al.  Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. , 1991, Journal of immunology.

[17]  J. Vane,et al.  Prostaglandins, Aspirin-like Drugs and the Oedema of Inflammation , 1973, Nature.

[18]  T. Hla,et al.  Human cyclooxygenase-2 cDNA. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[19]  A. L. Willis,et al.  Cutaneous reactions to intradermal prostaglandins , 1971, British journal of pharmacology.

[20]  C. McCall,et al.  Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages. , 1992, Biochemical and biophysical research communications.

[21]  T. Williams,et al.  Mediation of increased vascular permeability after complement activation. Histamine-independent action of rabbit C5a , 1981, The Journal of experimental medicine.

[22]  L. Lau,et al.  Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. , 1985, The EMBO journal.

[23]  J. Mitchell,et al.  Cyclo‐oxygenase and nitric oxide synthase isoforms in rat carrageenin‐induced pleurisy , 1994, British journal of pharmacology.

[24]  J. Calabro.  Efficacy of diclofenac in ankylosing spondylitis. , 1986, The American journal of medicine.

[25]  J. Vane,et al.  Induction of cyclo‐oxygenase‐2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone , 1994, British journal of pharmacology.

[26]  D. Dewitt,et al.  Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. , 1993, The Journal of biological chemistry.

[27]  K. Decker,et al.  Regulation by prostaglandin E2 of cytokine-elicited nitric oxide synthesis in rat liver macrophages. , 1992, Biological chemistry Hoppe-Seyler.

[28]  A. Mallet,et al.  Levels of arachidonic acid and its metabolites in the skin in human allergic and irritant contact dermatitis , 1984, The British journal of dermatology.

[29]  M. Rawlins,et al.  Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs , 1994, The Lancet.

[30]  S. Moncada,et al.  Actions of nitric oxide on the release of prostacyclin from bovine endothelial cells in culture. , 1988, European journal of pharmacology.

[31]  M. Greaves,et al.  Time course changes in levels of arachidonic acid and prostaglandins D2, E2, F2 alpha in human skin following ultraviolet B irradiation. , 1980, British journal of clinical pharmacology.

[32]  H R Herschman,et al.  Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant. , 1987, Oncogene.

[33]  Joseph Schlessinger,et al.  Signal transduction by receptors with tyrosine kinase activity , 1990, Cell.

[34]  G. Michaëlsson,et al.  Cutaneous vascular reactions to prostaglandins in healthy subjects and in patients with urticaria and atopic dermatitis. , 1969, Acta dermato-venereologica.

[35]  M. Greaves,et al.  Pharmacological studies in inflammation due to exposure to ultraviolet radiation , 1970, The Journal of pathology.

[36]  J. Fries,et al.  The relative toxicity of nonsteroidal antiinflammatory drugs. , 2010, Arthritis and rheumatism.

[37]  J. Falgueyret,et al.  Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid. , 1994, Molecular pharmacology.

[38]  H. Herschman,et al.  Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. , 1992, The Journal of biological chemistry.

[39]  R. Erikson,et al.  Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[40]  B. Alberts,et al.  Steroid receptors: elements for modulation of eukaryotic transcription. , 1976, Annual review of biochemistry.

[41]  R. Willkens.  Worldwide clinical safety experience with diclofenac. , 1985, Seminars in arthritis and rheumatism.

[42]  A M Walker,et al.  Nonsteroidal Antiinflammatory Drugs and Gastrointestinal Hospitalizations in Saskatchewan: A Cohort Study , 1992, Epidemiology.

[43]  W. Xie,et al.  Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs , 1992 .

[44]  F. Murad,et al.  Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[45]  C. Maggi,et al.  Arachidonic acid and bradykinin share a common pathway to release neuropeptide from capsaicin-sensitive sensory nerve fibers of the guinea pig heart. , 1991, The Journal of pharmacology and experimental therapeutics.

[46]  R. Nelson,et al.  A comparative endoscopic evaluation of the damaging effects of nonsteroidal anti-inflammatory agents on the gastric and duodenal mucosa. , 1981, The American journal of gastroenterology.

[47]  U. V. von Euler,et al.  Observations on the effects of infusion of prostaglandin E in man. , 1959, Acta physiologica Scandinavica.

[48]  T. Williams,et al.  Inflammatory mechanisms in the passive cutaneous anaphylactic reaction in the rabbit: evidence that novel mediators are involved , 1992, British journal of pharmacology.

[49]  J. Vane,et al.  Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. , 1971, Nature: New biology.

[50]  S. Hart,et al.  Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. , 1992, The Journal of biological chemistry.

[51]  J. Case,et al.  In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. , 1992, The Journal of clinical investigation.

[52]  T. Billiar,et al.  Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin‐6 by rat Kupffer cells , 1993, Journal of leukocyte biology.

[53]  C. Thiemermann,et al.  Involvement of tyrosine kinase in the induction of cyclo‐oxygenase and nitric oxide synthase by endotoxin in cultured cells , 1994, British journal of pharmacology.

[54]  S. Moncada,et al.  The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide , 1987, British journal of pharmacology.

[55]  T. Williams,et al.  Control of vascular permeability by polymorphonuclear leukocytes in inflammation , 1981, Nature.

[56]  K. Thierauch,et al.  Prostaglandins and their receptors: II. Receptor structure and signal transduction. , 1994, Journal of hypertension.

[57]  J. Richards,et al.  Evidence for two antigenically distinct molecular weight variants of prostaglandin H synthase in the rat ovary. , 1991, Molecular endocrinology.

[58]  G. Hunninghake,et al.  Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes. , 1994, The Journal of clinical investigation.

[59]  S. Snyder,et al.  Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[60]  H. Movat,et al.  The effect of vasodilator prostaglandins on polymorphonuclear leukocyte infiltration and vascular injury. , 1982, The American journal of pathology.

[61]  C. Smyth,et al.  A comparison of naproxen, indomethacin and aspirin in osteoarthritis. , 1980, The Journal of rheumatology.

[62]  S. Ferreira.  Prostaglandins, aspirin-like drugs and analgesia. , 1972, Nature: New biology.

[63]  Joanne,et al.  Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions. , 1993, The Journal of biological chemistry.

[64]  T. Williams,et al.  Cutaneous blood flow responses in the forearms of Raynaud's patients induced by local cooling and intradermal injections of CGRP and histamine. , 1990, British journal of clinical pharmacology.

[65]  J. Wallace,et al.  Prostaglandins, NSAIDs, and cytoprotection. , 1992, Gastroenterology clinics of North America.

[66]  E. Remmers,et al.  Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. , 1994, The Journal of clinical investigation.

[67]  F. Murad,et al.  Characterization of nitric oxide synthases in non‐adrenergic non‐cholinergic nerve containing tissue from the rat anococcygeus muscle , 1991, British journal of pharmacology.

[68]  F. Murad,et al.  Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[69]  L. Marnett,et al.  Prostaglandin and thromboxane biosynthesis. , 1991, Pharmacology & therapeutics.

[70]  P. Colville-Nash,et al.  Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Implications for their role in tissue development and repair processes. , 1993, Laboratory investigation; a journal of technical methods and pathology.

[71]  D. Dewitt.  Prostaglandin endoperoxide synthase: regulation of enzyme expression. , 1991, Biochimica et biophysica acta.

[72]  G. Palade,et al.  STUDIES ON INFLAMMATION: I. The Effect of Histamine and Serotonin on Vascular Permeability: An Electron Microscopic Study , 1961 .

[73]  M. Peck,et al.  Role of prostaglandin-mediated vasodilatation in inflammation , 1977, Nature.

[74]  J. Morrow,et al.  Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester. , 1994, The Journal of clinical investigation.

[75]  C. Nathan,et al.  Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[76]  K. Seibert,et al.  Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[77]  V. Winn,et al.  cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[78]  G. B. West,et al.  Prostaglandins as regulators of bradykinin responses , 1973 .

[79]  T. Williams,et al.  Prostaglandins as Potentiators of Increased Vascular Permeability in Inflammation , 1973, Nature.