Assessment of Skeletal Maturation in Nonsyndromic Cleft and Non-cleft Children—A Comparative Study

The study aims to determine the difference in the skeletal maturation of unilateral cleft lip and palate (UCLP) and non-cleft children. This study also attempts to determine sexual dimorphism in attaining skeletal maturation between UCLP and non-cleft children. This was a retrospective, cross-sectional study. The total sample consisted of the lateral cephalogram of 131 UCLP (62 female and 71 male) children and 500 (274 female and 226 male) non-cleft children. The reviewer used the Baccetti method (2005) to review all the cephalograms for the cervical vertebrae maturation (CVM) stages. T-test was used to compare the mean chronological age and skeletal maturation of cleft and non-cleft children at each CVM stage. There was no significant difference in the mean chronological age and skeletal maturation status of UCLP and non-cleft children. There was no significant difference in skeletal maturation based on sex. The intraobserver assessment showed 80% and 85% kappa agreement, signifying absolute agreement. The correlation coefficient between chronological age and CVMIs was 0.86 (P<0.001) in cleft children and 0.76 (P<0.001) in non-cleft children, which was highly significant. The study indicates no significant difference in the skeletal maturation of UCLP and non-cleft children and no sex-related difference.

[1]  T. Tripathi,et al.  A comparative cervical verteberal maturity index evaluation of skeletal age in cleft and non-Cleft patients , 2022, IP Indian Journal of Orthodontics and Dentofacial Research.

[2]  Zhenqi Chen,et al.  Assessment of Skeletal Maturation in Male Children With Unilateral Cleft Lip and Palate , 2022, The Journal of craniofacial surgery.

[3]  T. Tripathi,et al.  Non-invasive methods for the assessment of biomarkers and their correlation with radiographic maturity indicators — a scoping review , 2021, Progress in Orthodontics.

[4]  Jie Zheng,et al.  Skeletal Maturation in Patients With Cleft Lip and/or Palate: A Systematic Review , 2021, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

[5]  A. Verdonck,et al.  Assessment of craniofacial maturation in preadolescents with cleft lip and/or palate using the cervical vertebral maturation method , 2021, Clinical Oral Investigations.

[6]  L. Arriola-Guillén,et al.  Midpalatal suture maturation stage assessment in adolescents and young adults using cone-beam computed tomography , 2019, Progress in Orthodontics.

[7]  Endah Mardiati,et al.  Physiological maturation stage of cervical vertebrate index in cleft lip/palate and non-cleft lip/palate patients , 2019, Majalah Kedokteran Gigi Indonesia.

[8]  Mariela Ramírez-Velásquez,et al.  Maturation of cervical vertebrae and chronological age in children and adolescents. , 2018, Acta odontológica latinoamericana.

[9]  K. Zawawi,et al.  The Difference in Cervical Vertebral Skeletal Maturation between Cleft Lip/Palate and Non-Cleft Lip/Palate Orthodontic Patients , 2018, BioMed research international.

[10]  Lorenzo Franchi,et al.  The cervical vertebral maturation method: A user's guide. , 2018, The Angle orthodontist.

[11]  J. Losee,et al.  The impact of cleft lip and palate repair on maxillofacial growth , 2014, International Journal of Oral Science.

[12]  M. Ravi,et al.  Assessment of Skeletal Age in Children with Unilateral Cleft Lip and Palate , 2013, International journal of clinical pediatric dentistry.

[13]  K. Godfrey,et al.  A comparison of cervical vertebral maturation assessment of skeletal growth stages with chronological age in Thai between cleft lip and palate and non-cleft patients. , 2013, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[14]  Ling Sun,et al.  Cervical Vertebral Maturation of Children with Orofacial Clefts , 2012, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

[15]  E. J. Bowers.  Growth in Children with Clefts: Serial Hand-Wrist X-Ray Evidence , 2011, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

[16]  J. Shuster,et al.  Longitudinal Study of Growth of Children with Unilateral Cleft-Lip Palate from Birth to Two Years of Age , 2009, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

[17]  P. Major,et al.  Correlation of skeletal maturation stages determined by cervical vertebrae and hand-wrist evaluations. , 2009, The Angle orthodontist.

[18]  Lorenzo Franchi,et al.  An improved version of the cervical vertebral maturation (CVM) method for the assessment of mandibular growth. , 2009, The Angle orthodontist.

[19]  C J Hunter,et al.  The correlation of facial growth with body height and skeletal maturation at adolescence. , 2009, The Angle orthodontist.

[20]  D. Beaumont.  A study into weight gain in infants with cleft lip/palate. , 2008, Paediatric nursing.

[21]  A. Palmieri,et al.  Human genetic factors in nonsyndromic cleft lip and palate: an update. , 2007, International journal of pediatric otorhinolaryngology.

[22]  F. Bianchi,et al.  Associated anomalies in multi‐malformed infants with cleft lip and palate: An epidemiologic study of nearly 6 million births in 23 EUROCAT registries , 2007, American journal of medical genetics. Part A.

[23]  Tancan Uysal,et al.  Chronologic age and skeletal maturation of the cervical vertebrae and hand-wrist: is there a relationship? , 2006, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[24]  S. Goyal,et al.  Comparative evaluation of hand wrist radiographs with cervical vertebrae for skeletal maturation in 10-12 years old children. , 2006, Journal of the Indian Society of Pedodontics and Preventive Dentistry.

[25]  W. Proffit.  The timing of early treatment: an overview. , 2006, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[26]  P. Ngan.  Early treatment of Class III malocclusion: is it worth the burden? , 2006, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[27]  James A. McNamara,et al.  The Cervical Vertebral Maturation (CVM) Method for the Assessment of Optimal Treatment Timing in Dentofacial Orthopedics , 2005 .

[28]  M. Cobourne.  The complex genetics of cleft lip and palate. , 2004, European journal of orthodontics.

[29]  J. Murray.  Gene/environment causes of cleft lip and/or palate , 2002, Clinical genetics.

[30]  J. Hoeksma,et al.  Growth comparison between children with cleft lip and/or palate and controls. , 1992, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.

[31]  H. Pancherz,et al.  Dentofacial orthopedics in relation to somatic maturation. An analysis of 70 consecutive cases treated with the Herbst appliance. , 1985, American journal of orthodontics.

[32]  U. Hägg,et al.  Dental maturity as an indicator of chronological age: the accuracy and precision of three methods. , 1985, European journal of orthodontics.

[33]  L S Fishman,et al.  Radiographic evaluation of skeletal maturation. A clinically oriented method based on hand-wrist films. , 1982, The Angle orthodontist.

[34]  M. Kutner,et al.  Prevalence of growth hormone deficiency in children with cleft lip or palate. , 1978, The Journal of pediatrics.

[35]  M. Mazaheri,et al.  Height-weight growth of cleft children, birth to six years. , 1975, The Cleft palate journal.

[36]  N. Eslami,et al.  Do Patients With Cleft Lip and Palate Differ From Normal Individuals in Skeletal Maturity? , 2019, The Journal of craniofacial surgery.

[37]  P. Kopczyński,et al.  Analysis of skeletal maturity of children with cleft palate in terms of healthy children by the CVM method. , 2015, Advances in clinical and experimental medicine : official organ Wroclaw Medical University.

[38]  A. Farman,et al.  Skeletal maturation evaluation using cervical vertebrae. , 1995, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[39]  R. B. Ross.  Treatment variables affecting facial growth in complete unilateral cleft lip and palate. , 1987, The Cleft palate journal.

[40]  U. Hägg,et al.  Skeletal stages of the hand and wrist as indicators of the pubertal growth spurt. , 1980, Acta odontologica Scandinavica.

[41]  J. A. Menius,et al.  Skeletal development of cleft palate children as determined by hand-wrist roentgenographs: a preliminary study. , 1966, The Cleft palate journal.