Fully inkjet-printed microfluidics: a solution to low-cost rapid three-dimensional microfluidics fabrication with numerous electrical and sensing applications

As the needs for low-cost rapidly-produced microfluidics are growing with the trend of Lab-on-a-Chip and distributed healthcare, the fully inkjet-printing of microfluidics can be a solution to it with numerous potential electrical and sensing applications. Inkjet-printing is an additive manufacturing technique featuring no material waste and a low equipment cost. Moreover, similar to other additive manufacturing techniques, inkjet-printing is easy to learn and has a high fabrication speed, while it offers generally a great planar resolution down to below 20 µm and enables flexible designs due to its inherent thin film deposition capabilities. Due to the thin film feature, the printed objects also usually obtain a high vertical resolution (such as 4.6 µm). This paper introduces a low-cost rapid three-dimensional fabrication process of microfluidics, that relies entirely on an inkjet-printer based single platform and can be implemented directly on top of virtually any substrates.

[1]  Bingcheng Lin,et al.  Rapid prototyping of paper‐based microfluidics with wax for low‐cost, portable bioassay , 2009, Electrophoresis.

[2]  Wei Wang,et al.  Lab-on-a-print: from a single polymer film to three-dimensional integrated microfluidics. , 2009, Lab on a chip.

[3]  G. Jabbour,et al.  Inkjet Printing—Process and Its Applications , 2010, Advanced materials.

[4]  Bastian E. Rapp,et al.  Let there be chip—towards rapid prototyping of microfluidic devices: one-step manufacturing processes , 2011 .

[5]  G. Kovacs.  Micromachined Transducers Sourcebook , 1998 .

[6]  Aliaa I. Shallan,et al.  Cost-effective three-dimensional printing of visibly transparent microchips within minutes. , 2014, Analytical chemistry.

[7]  A. Arias,et al.  Materials and applications for large area electronics: solution-based approaches. , 2010, Chemical reviews.

[8]  Albert Folch,et al.  Mail-order microfluidics: evaluation of stereolithography for the production of microfluidic devices. , 2014, Lab on a chip.

[9]  H. Cai,et al.  A SU-8/PDMS Hybrid Microfluidic Device with Integrated Optical Fibers for Online Monitoring of Lactate , 2005, Biomedical microdevices.

[10]  Phil Stephens,et al.  Simple and Versatile 3D Printed Microfluidics Using Fused Filament Fabrication , 2016, PloS one.

[11]  Bethany C Gross,et al.  3D printed microfluidic devices with integrated versatile and reusable electrodes. , 2014, Lab on a chip.

[12]  George M Whitesides,et al.  Prototyping of microfluidic devices in poly(dimethylsiloxane) using solid-object printing. , 2002, Analytical chemistry.

[13]  C. Grigoropoulos,et al.  All-inkjet-printed flexible electronics fabrication on a polymer substrate by low-temperature high-resolution selective laser sintering of metal nanoparticles , 2007 .

[14]  D. Citterio,et al.  Inkjet-printed microfluidic multianalyte chemical sensing paper. , 2008, Analytical chemistry.

[15]  R. Bhargava,et al.  Monolithic multilayer microfluidics via sacrificial molding of 3D-printed isomalt. , 2015, Lab on a chip.

[16]  Wenjing Su,et al.  Development of Low Cost, Wireless, Inkjet Printed Microfluidic RF Systems and Devices for Sensing or Tunable Electronics , 2015, IEEE Sensors Journal.

[17]  D. Diamond,et al.  Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications. , 2014, Biomicrofluidics.

[18]  Catherine A. Rivet,et al.  Microfluidics for medical diagnostics and biosensors , 2011 .

[19]  G. Whitesides.  The origins and the future of microfluidics , 2006, Nature.

[20]  Albert Folch,et al.  3D-printed microfluidic automation. , 2015, Lab on a chip.

[21]  Nam-Trung Nguyen,et al.  SU‐8 as a structural material for labs‐on‐chips and microelectromechanical systems , 2007, Electrophoresis.

[22]  Govind V Kaigala,et al.  Rapid prototyping of microfluidic devices with a wax printer. , 2007, Lab on a chip.

[23]  Manos M. Tentzeris,et al.  3D/inkjet-printed origami antennas for multi-direction RF harvesting , 2015, 2015 IEEE MTT-S International Microwave Symposium.

[24]  A. Offenhäusser,et al.  Inkjet printing of UV-curable adhesive and dielectric inks for microfluidic devices. , 2016, Lab on a chip.

[25]  U. Kaatze,et al.  DIELECTRIC RELAXATION OF H-BONDED LIQUIDS. MIXTURES OF ETHANOL AND N-HEXANOL AT DIFFERENT COMPOSITIONS AND TEMPERATURES , 1999 .

[26]  Yang Wang,et al.  Printed electronics integrated with paper-based microfluidics: new methodologies for next-generation health care , 2015 .

[27]  G. Whitesides,et al.  Flexible Methods for Microfluidics , 2001 .

[28]  G. Whitesides,et al.  Three-dimensional microfluidic devices fabricated in layered paper and tape , 2008, Proceedings of the National Academy of Sciences.

[29]  Bethany C Gross,et al.  Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. , 2014, Analytical chemistry.

[30]  D. Mooradian,et al.  Hemocompatibility of materials used in microelectromechanical systems: platelet adhesion and morphology in vitro. , 2002, Journal of biomedical materials research.

[31]  Gábor Harsányi,et al.  Characterization of rapid PDMS casting technique utilizing molding forms fabricated by 3D rapid prototyping technology (RPT) , 2014 .

[32]  Sidra Waheed,et al.  3D printed microfluidic devices: enablers and barriers. , 2016, Lab on a chip.

[33]  S. Kazarian,et al.  Rapid prototyping of microfluidic devices for integrating with FT-IR spectroscopic imaging. , 2010, Lab on a chip.

[34]  Wenjing Su,et al.  Additively Manufactured Nanotechnology and Origami-Enabled Flexible Microwave Electronics , 2015, Proceedings of the IEEE.

[35]  Manos M. Tentzeris,et al.  An Inkjet-Printed Microfluidic RFID-Enabled Platform for Wireless Lab-on-Chip Applications , 2013, IEEE Transactions on Microwave Theory and Techniques.

[36]  L. Roselli,et al.  Inkjet-printed dual microfluidic-based sensor integrated system , 2015, 2015 IEEE SENSORS.

[37]  G. Whitesides,et al.  Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). , 1998, Analytical chemistry.