Cervicovaginal cellular angiofibroma

Cellular angiofibroma is a rare type of benign mesenchymal tumour that arises mostly in middle-aged women. It needs to be distinguished from other neoplasms and has a predilection for the vulvovaginal region. To our knowledge, this is the first case of a cervical cellular angiofibroma. A 34-year-old nulligravid woman was referred with a large mass bulging in the fornix posterior. Ultrasound scanning and MRI showed a large solid mass projecting in the pouch of Douglas. Laparoscopic surgical excision was performed. Histopathological examination showed a well-demarcated, unencapsulated tumour, consisting of short fascicles of spindle cells in-between thick-walled medium-sized vessels. On immunohistochemistry, there was strong reactivity with antibodies against CD34 and oestrogen receptor. Angiofibromas are benign mesenchymal tumours mostly occurring in middle-aged women. They can cause abnormal swelling and uterine bleeding and need to be distinguished from other (malignant) neoplasms.

[1]  Chuchu Arega,et al.  Angiofibroma of the Vagina Presenting with Abnormal Vaginal Bleeding: A Case Report from Ethiopia and Review of the Literature , 2019, Case reports in obstetrics and gynecology.

[2]  A. Cavazza,et al.  Cellular angiofibroma in women: a review of the literature , 2015, Diagnostic Pathology.

[3]  J. K. Schoolmeester,et al.  Genital soft tissue tumors , 2015, Journal of cutaneous pathology.

[4]  T. Lue,et al.  Commonly used mesenchymal stem cell markers and tracking labels: Limitations and challenges. , 2013, Histology and histopathology.

[5]  W. Laskin,et al.  Soft Tissue Lesions Involving Female Reproductive Organs , 2011 .

[6]  T. Mentzel,et al.  Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma , 2011, Modern Pathology.

[7]  C. Fletcher,et al.  Cellular Angiofibroma With Atypia or Sarcomatous Transformation: Clinicopathologic Analysis of 13 Cases , 2010, The American journal of surgical pathology.

[8]  R. Sciot,et al.  Cellular angiofibroma: another mesenchymal tumour with 13q14 involvement, suggesting a link with spindle cell lipoma and (extra)mammary myofibroblastoma , 2007, Histopathology.

[9]  E. Montgomery,et al.  Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature. , 2005, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[10]  C. Fletcher,et al.  Cellular Angiofibroma: Clinicopathologic and Immunohistochemical Analysis of 51 Cases , 2004, The American journal of surgical pathology.

[11]  W. McCluggage,et al.  Cellular angiofibroma and related fibromatous lesions of the vulva: report of a series of cases with a morphological spectrum wider than previously described , 2004, Histopathology.

[12]  J. Noël,et al.  Cellular angiofibroma of the vulva: a clinicopathological study of two cases with documentation of some unusual features and review of the literature , 2003, Journal of cutaneous pathology.

[13]  T. Beer Digital imaging of surgical specimens. , 2002, Journal of Clinical Pathology.

[14]  W. McCluggage,et al.  Recurrent cellular angiofibroma of the vulva. , 2002, Journal of clinical pathology.

[15]  J. Lane,et al.  Cellular angiofibroma of the vulva. , 2001, Gynecologic oncology.

[16]  M. Nucci,et al.  Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. , 1997, The American journal of surgical pathology.