Diagnostic significance of DNA methylation of PTEN and DAPK in thyroid tumors

DNA Methylation of the tumour suppressor gene leading to gene silencing plays an important role in thyroid tumour development. The purpose was to determine the DNA methylation status of phosphatase and tensin homolog (PTEN) and death‐associated protein kinase (DAPK) in patients with thyroid nodules and to explore whether they can be used as molecular diagnostic tools to differentiate benign and malignant thyroid nodules.

[1]  M. Jordà,et al.  DNA methylation in thyroid cancer. , 2019, Endocrine-related cancer.

[2]  M. Fanciulli,et al.  PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise? , 2019, Cancers.

[3]  Kecheng Zhang,et al.  DNA methylation alterations as therapeutic prospects in thyroid cancer , 2018, Journal of Endocrinological Investigation.

[4]  Dawei Sun,et al.  Relationship between DAPK methylation and gene inactivation in papillary thyroid carcinoma , 2018 .

[5]  Janeil M Mitchell,et al.  An update in international trends in incidence rates of thyroid cancer, 1973–2007 , 2018, Cancer Causes & Control.

[6]  S. Mandel,et al.  The Diagnosis and Management of Thyroid Nodules: A Review , 2018, JAMA.

[7]  P. Santisteban,et al.  Key signaling pathways in thyroid cancer. , 2017, The Journal of endocrinology.

[8]  R. Heshmat,et al.  Meta-analysis of promoter methylation in eight tumor-suppressor genes and its association with the risk of thyroid cancer , 2017, PloS one.

[9]  Haipeng Xiao,et al.  Review of Factors Related to the Thyroid Cancer Epidemic , 2017, International journal of endocrinology.

[10]  K. Sun,et al.  The Expression Level of mRNA, Protein, and DNA Methylation Status of FOSL2 of Uyghur in XinJiang in Type 2 Diabetes , 2016, Journal of diabetes research.

[11]  J. Sosa,et al.  The changing incidence of thyroid cancer , 2016, Nature Reviews Endocrinology.

[12]  H. Moses,et al.  Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss. , 2016, Cancer research.

[13]  Huan-huan Chen,et al.  Value of TIRADS, BSRTC and FNA-BRAFV600E mutation analysis in differentiating high-risk thyroid nodules , 2015, Scientific Reports.

[14]  Z. Jehan,et al.  PTEN loss is associated with follicular variant of Middle Eastern papillary thyroid carcinoma , 2015, British Journal of Cancer.

[15]  A. Kwong,et al.  Elevation of methylated DNA in KILLIN/PTEN in the plasma of patients with thyroid and/or breast cancer , 2014, OncoTargets and Therapy.

[16]  W. Tan,et al.  PTEN hamartoma tumour syndrome: early tumour development in children , 2014, Archives of Disease in Childhood.

[17]  Yun Wu,et al.  The clinical significance of tumor suppressor gene methylation, expression in nodular thyroid disease , 2013 .

[18]  N. Fortunati,et al.  Epigenetics Modifications and Therapeutic Prospects in Human Thyroid Cancer , 2012, Front. Endocrin..

[19]  R. Nagy,et al.  Frequency of germline PTEN mutations in differentiated thyroid cancer. , 2011, Thyroid : official journal of the American Thyroid Association.

[20]  A. Michie,et al.  Death‐associated protein kinase (DAPK) and signal transduction: regulation in cancer , 2010, The FEBS journal.

[21]  A. Shaha,et al.  Investigating the thyroid nodule , 2009, BMJ : British Medical Journal.

[22]  P. Hou,et al.  Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3‐kinase/AKT signaling pathway in thyroid tumors , 2008, Cancer.

[23]  J. Califano,et al.  Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer , 2006, International journal of cancer.

[24]  M. Kokoska,et al.  Methylation status of genes in papillary thyroid carcinoma. , 2006, Archives of otolaryngology--head & neck surgery.

[25]  A. Kimchi,et al.  The death-associated protein kinases: structure, function, and beyond. , 2006, Annual review of biochemistry.

[26]  A. de Leiva,et al.  PTEN promoter methylation in sporadic thyroid carcinomas. , 2006, Thyroid : official journal of the American Thyroid Association.

[27]  G. Tell,et al.  Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells. , 2004, Endocrinology.

[28]  C. Compton,et al.  Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. , 2004, Cancer research.

[29]  W. Farrell,et al.  Preferential loss of Death Associated Protein kinase expression in invasive pituitary tumours is associated with either CpG island methylation or homozygous deletion , 2002, Oncogene.

[30]  C. Eng,et al.  Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death. , 2001, Human molecular genetics.

[31]  G. Viglietto,et al.  PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells is mediated by p27kip1 , 2000, Oncogene.

[32]  J. Yeh,et al.  Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. , 2000, The American journal of pathology.

[33]  F. Azizi,et al.  Epigenetic modifications in human thyroid cancer (Review) , 2015 .

[34]  J. Jonklaas,et al.  Thyroid nodules. , 2012, The Medical clinics of North America.