The relative densities of pharmaceutical powders, blends, dry granulations, and immediate-release tablets

The absolute and relative densities of pharmaceutical solids play an important role in determining their performance (e.g., flow and compaction properties) in both tablet and capsule dosage forms. In this article, the authors report the densities of a wide variety of solid pharmaceutical formulations and intermediates. The variance of density with chemical structure, processing history, and dosage-form type is significant.This study shows that density can be used as an equipment-independent scaling parameter for several common drug-product manufacturing operations.

[1]  Derek Geldart,et al.  The use of bulk density measurements as flowability indicators , 1999 .

[2]  R. M. Spriggs.  Expression for Effect of Porosity on Elastic Modulus of Polycrystalline Refractory Materials, Particularly Aluminum Oxide , 1961 .

[3]  J. M. Newton,et al.  The prediction of the bulk densities of powder mixtures, and its relationship to the filling of hard gelatin capsules , 1981, The Journal of pharmacy and pharmacology.

[4]  David E. Bugay,et al.  Physical Characterization of Pharmaceutical Solids , 1995, Pharmaceutical Research.

[5]  Bruno C. Hancock,et al.  Micro-scale measurement of the mechanical properties of compressed pharmaceutical powders. 1: The elasticity and fracture behavior of microcrystalline cellulose. , 2000, International journal of pharmaceutics.

[6]  V. Lehmann,et al.  1H-NMR microscopy of tablets. , 1995, Journal of pharmaceutical sciences.

[7]  A. Kibbe.  Handbook of Pharmaceutical Excipients , 2003 .

[8]  J. Bultmann.  Multiple compaction of microcrystalline cellulose in a roller compactor. , 2002, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[9]  Susan J. Bogdanowich,et al.  Changes in Material Properties Accompanying the National Formulary (NF) Identity Test for Microcrystalline Cellulose , 2004, Pharmaceutical Research.

[10]  S. Nara.  On the Relationship between Specific Volume and Crystallinity of Starch , 1979 .

[11]  A. Rozier,et al.  Functionality testing of gellan gum, a polymeric excipient material for ophthalmic dosage forms , 1997 .

[12]  G. Alderborn,et al.  Analysis of the Compression Mechanics of Pharmaceutical Agglomerates of Different Porosity and Composition Using the Adams and Kawakita Equations , 2000, Pharmaceutical Research.

[13]  Anthony Chi-Ying Wong,et al.  Characterisation of the flowability of glass beads by bulk densities ratio , 2000 .