Glucocorticoids and insulin resistance: old hormones, new targets.
暂无分享,去创建一个
[1] B. Walker,et al. 11 beta-hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver. , 2000, The Journal of endocrinology.
[2] A Mari,et al. How to measure insulin sensitivity , 1998, Journal of hypertension.
[3] P. Björntorp,et al. Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society Stress-Related Cortisol Secretion in Men: Relationships with Abdominal Obesity and Endocrine, Metabolic and , 2022 .
[4] J. Connell,et al. Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects. , 1998, The Journal of clinical endocrinology and metabolism.
[5] C. Östenson,et al. Increased glucocorticoid sensitivity in islet beta-cells: effects on glucose 6-phosphatase, glucose cycling and insulin release , 1998, Diabetologia.
[6] M. Nyirenda,et al. Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. , 1998, The Journal of clinical investigation.
[7] B. Walker,et al. Obesity and gender influence cortisol secretion and metabolism in man. , 1998, The Journal of clinical endocrinology and metabolism.
[8] D. Webb,et al. Increased glucocorticoid activity in men with cardiovascular risk factors. , 1998, Hypertension.
[9] Jeppe Sturis,et al. Temporal Profiles and Clinical Significance of Pulsatile Insulin Secretion , 1998, Hormone Research in Paediatrics.
[10] J. Seckl,et al. 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[11] F. Veglio,et al. Impaired cortisol binding to glucocorticoid receptors in hypertensive patients. , 1997, Hypertension.
[12] S. Jacob,et al. Insulin Resistance, Hyperinsulinemia, and Blood Pressure Role of Age and Obesity , 1997 .
[13] C. Östenson,et al. Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids. , 1997, The Journal of clinical investigation.
[14] S. O’Rahilly,et al. Molecular mechanisms of inherited insulin resistance. , 1997, QJM : monthly journal of the Association of Physicians.
[15] S. Woods,et al. Adrenalectomy Increases Sensitivity to Central Insulin , 1997, Physiology & Behavior.
[16] E. Ferrannini,et al. Renal effects of insulin in man. , 1997, Journal of nephrology.
[17] E. Araki,et al. Impact of Natural IRS-1 Mutations on Insulin Signals: Mutations of IRS-1 in the PTB Domain and Near SH2 Protein Binding Sites Result in Impaired Function at Different Steps of IRS-1 Signaling , 1997, Diabetes.
[18] M. Jimenez-Linan,et al. Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. , 1997, The Journal of clinical investigation.
[19] P. Stewart,et al. Does central obesity reflect “Cushing's disease of the omentum”? , 1997, The Lancet.
[20] C. Kahn,et al. Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles , 1997, Cell.
[21] P. Gilon,et al. Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. , 1997, The Journal of clinical investigation.
[22] G. Dimitriadis,et al. Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle. , 1997, The Biochemical journal.
[23] G. Boden. Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM , 1997, Diabetes.
[24] J. Seckl,et al. Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. , 1996, Neuroendocrinology.
[25] H. Sipilä,et al. Evidence for Dissociation of Insulin Stimulation of Blood Flow and Glucose Uptake in Human Skeletal Muscle: Studies Using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and Positron Emission Tomography , 1996, Diabetes.
[26] J. Seckl,et al. Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: studies with the 11 b -hydroxysteroid dehydrogenase inhibitor carbenoxolone , 1996, Diabetologia.
[27] G. Vallega,et al. In vivo effects of dexamethasone and sucrose on glucose transport (GLUT-4) protein tissue distribution. , 1996, The American journal of physiology.
[28] S. O’Rahilly,et al. Severe insulin resistance, diabetes mellitus, hypertriglyceridemia, and pseudoacromegaly. , 1996, The Journal of clinical endocrinology and metabolism.
[29] D. Finegood,et al. The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. , 1996, The Journal of clinical endocrinology and metabolism.
[30] P. Björntorp,et al. Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study. , 1996, Obesity research.
[31] R. Stolk,et al. Gender differences in the associations between cortisol and insulin in healthy subjects. , 1996, The Journal of endocrinology.
[32] J. Filipovský,et al. The relationship of blood pressure with glucose, insulin, heart rate, free fatty acids and plasma cortisol levels according to degree of obesity in middle-aged men , 1996, Journal of hypertension.
[33] B. Walker,et al. Increased vasoconstrictor sensitivity to glucocorticoids in essential hypertension. , 1996, Hypertension.
[34] C. Edwards,et al. 11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. , 1995, Endocrinology.
[35] D. Webb,et al. Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. , 1995, The Journal of clinical endocrinology and metabolism.
[36] G. Boden,et al. Effects of a 48-h Fat Infusion on Insulin Secretion and Glucose Utilization , 1995, Diabetes.
[37] T. Mune,et al. Human hypertension caused by mutations in the kidney isozyme of 11β–hydroxysteroid dehydrogenase , 1995, Nature Genetics.
[38] A. Baron,et al. Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans. , 1995, The Journal of clinical investigation.
[39] M. Itoh,et al. Dexamethasone-induced changes in glucose transporter 4 in rat heart muscle, skeletal muscle and adipocytes. , 1995, European journal of endocrinology.
[40] S. Weinstein,et al. Glucocorticoid-Induced Insulin Resistance: Dexamethasone Inhibits the Activation of Glucose Transport in Rat Skeletal Muscle by Both Insulin- and Non-Insulin-Related Stimuli , 1995, Diabetes.
[41] I. Robinson,et al. Sexual dimorphism of hepatic 11 beta-hydroxysteroid dehydrogenase in the rat: the role of growth hormone patterns. , 1994, The Journal of endocrinology.
[42] Z. Krozowski,et al. Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme , 1994, Molecular and Cellular Endocrinology.
[43] T. Mune,et al. NAD(+)-dependent isoform of 11 beta-hydroxysteroid dehydrogenase. Cloning and characterization of cDNA from sheep kidney. , 1994, The Journal of biological chemistry.
[44] C. Edwards,et al. 'Liver-type' 11 beta-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells. , 1994, Journal of molecular endocrinology.
[45] A. Quyyumi,et al. Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that the abnormality is not at the muscarinic receptor level. , 1994, Journal of the American College of Cardiology.
[46] F. Féry. Role of hepatic glucose production and glucose uptake in the pathogenesis of fasting hyperglycemia in type 2 diabetes: normalization of glucose kinetics by short-term fasting. , 1994, The Journal of clinical endocrinology and metabolism.
[47] R. Clayton,et al. Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase. , 1994, The New England journal of medicine.
[48] Marie Martin,et al. In vivo effect of free fatty acids on the specific binding of glucocorticosteroids to corticosteroid binding globulin and liver receptors in immature rats , 1994, Steroids.
[49] R. Rizza,et al. Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans. , 1993, The Journal of clinical investigation.
[50] A. Atkinson,et al. The effect of cortisol on glucose/glucose-6-phosphate cycle activity and insulin action. , 1993, The Journal of clinical endocrinology and metabolism.
[51] H. Adlercreutz,et al. Altered adrenocorticotropin and Cortisol secretion in abdominal obesity: implications for the insulin resistance syndrome , 1993, Journal of internal medicine.
[52] M. Dallman,et al. Feast and Famine: Critical Role of Glucocorticoids with Insulin in Daily Energy Flow , 1993, Frontiers in Neuroendocrinology.
[53] R. Pasquali,et al. The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. , 1993, The Journal of clinical endocrinology and metabolism.
[54] B. Walker,et al. Deficient inactivation of cortisol by 11β‐hydroxysteroid dehydrogenase in essential hypertension , 1993, Clinical endocrinology.
[55] H. Elayan,et al. Glucocorticoid induction of epinephrine synthesizing enzyme in rat skeletal muscle and insulin resistance. , 1993, The Journal of clinical investigation.
[56] C. Lau,et al. Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients , 1993, The Lancet.
[57] F. Giorgino,et al. Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo. , 1993, The Journal of clinical investigation.
[58] A. Quyyumi,et al. Effect of antihypertensive treatment on endothelium-dependent vascular relaxation in patients with essential hypertension. , 1993, Journal of the American College of Cardiology.
[59] R. Benediktsson,et al. Glucocorticoid exposure in utero: new model for adult hypertension , 1993, The Lancet.
[60] B. Walker,et al. Mineralocorticoid excess and inhibition of 11 β‐hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome , 1992, Clinical endocrinology.
[61] G. Hitman,et al. An association between a Bc1I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women. , 1992, Journal of molecular endocrinology.
[62] P. Björntorp,et al. Cortisol secretion in relation to body fat distribution in obese premenopausal women. , 1992, Metabolism: clinical and experimental.
[63] L. Groop,et al. Reversal of steroid-induced insulin resistance by a nicotinic-acid derivative in man. , 1992, Metabolism: clinical and experimental.
[64] G. Watt,et al. Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: a four-corners approach to the identification of genetic determinants of blood pressure. , 1992, Journal of hypertension.
[65] R. Simsolo,et al. The regulation of lipoprotein lipase gene expression by dexamethasone in isolated rat adipocytes. , 1992, Endocrinology.
[66] P. Stewart,et al. Novel aspects of hormone action: Intracellular ligand supply and its control by a series of tissue specific enzymes , 1992, Molecular and Cellular Endocrinology.
[67] A. Vanet,et al. Modulatory effects of unsaturated fatty acids on the binding of glucocorticoids to rat liver glucocorticoid receptors. , 1991, Endocrinology.
[68] P. Björntorp. Visceral fat accumulation: the missing link between psychosocial factors and cardiovascular disease? , 1991, Journal of internal medicine.
[69] D. York,et al. Central glucocorticoid regulation of parasympathetic drive to pancreatic B-cells in the obese fa/fa rat. , 1991, International journal of obesity.
[70] P. Siiteri,et al. Regulation of 11 beta-hydroxysteroid dehydrogenase activity in human skin fibroblasts: enzymatic modulation of glucocorticoid action. , 1991, The Journal of clinical endocrinology and metabolism.
[71] M. Vranic,et al. Dexamethasone increases glucose cycling, but not glucose production, in healthy subjects. , 1990, The American journal of physiology.
[72] C. Edwards,et al. 5 α-reductase activity in polycystic ovary syndrome , 1990, The Lancet.
[73] P. White,et al. Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase. , 1989, The Journal of biological chemistry.
[74] J Golding,et al. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. , 1989, BMJ.
[75] J. Funder,et al. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. , 1988, Science.
[76] D. Giannella‐Neto,et al. GLUCOCORTICOIDS AND GLUCOSE METABOLISM: HEPATIC GLUCOSE PRODUCTION IN UNTREATED ADDISONIAN PATIENTS AND ON TWO DIFFERENT LEVELS OF GLUCOCORTICOID ADMINISTRATION , 1988, Clinical endocrinology.
[77] P. Stewart,et al. MINERALOCORTICOID ACTIVITY OF LIQUORICE: 11-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY COMES OF AGE , 1987, The Lancet.
[78] G. Reaven,et al. A ROLE FOR INSULIN IN THE AETIOLOGY AND COURSE OF HYPERTENSION? , 1987, The Lancet.
[79] D. Housman,et al. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. , 1987, Science.
[80] J. Funder,et al. Mineralocorticoid specificity of renal type I receptors: in vivo binding studies. , 1987, The American journal of physiology.
[81] M. Cassader,et al. An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects. , 1983, The Journal of clinical investigation.
[82] J. Funder,et al. Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[83] D. Linch,et al. CUSHING'S SYNDROME—KILLING DISEASE: DISCRIMINATORY VALUE OF SIGNS AND SYMPTOMS AIDING EARLY DIAGNOSIS , 1982, The Lancet.
[84] I. G. Fantus,et al. The effect of glucocorticoids on the insulin receptor: an in vivo and in vitro study. , 1981, The Journal of clinical endocrinology and metabolism.
[85] I. Testa,et al. Effect of dexamethasone and cortisone on insulin receptors in normal human male. , 1980, The Journal of clinical endocrinology and metabolism.
[86] C. Kahn,et al. Alterations in insulin binding induced by changes in vivo in the levels of glucocorticoids and growth hormone. , 1978, Endocrinology.
[87] O. Owen,et al. Metabolic effects of exogenous glucocorticoids in fasted man. , 1973, The Journal of clinical investigation.
[88] B. Walker,et al. 11 -Hydroxysteroid dehydrogenase type 1 is a predominant 11 -reductase in the intact perfused rat liver , 2000 .
[89] M. Nyirenda,et al. Interactions between oestradiol and glucocorticoid regulatory effects on liver-specific glucocorticoid-inducible genes: possible evidence for a role of hepatic 11beta-hydroxysteroid dehydrogenase type 1. , 1999, The Journal of endocrinology.
[90] M. Hewison,et al. Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes. , 1998, The Journal of endocrinology.
[91] K. E. Chapman,et al. 11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated. , 1998, The Journal of steroid biochemistry and molecular biology.
[92] R. Hanson,et al. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. , 1997, Annual review of biochemistry.
[93] N. Glorioso,et al. Evidence of Coexisting Changes in 11β-Hydroxysteroid Dehydrogenase and 5β-Reductase Activity in Subjects With Untreated Essential Hypertension , 1995 .
[94] C. Edwards,et al. Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice on 11 beta-hydroxysteroid dehydrogenase activity in man. , 1990, Clinical science.
[95] C. Edwards,et al. Localisation of 11 beta-hydroxysteroid dehydrogenase--tissue specific protector of the mineralocorticoid receptor. , 1988, Lancet.
[96] A. Wallace,et al. MINERALOCORTICOID ACTIVITY OF LIQUORICE: 11Β-HYDROXYSTEROID DEHYDROGENASE DEFFICIENCY COMES OF AGE , 1987 .
[97] L. Mandarino,et al. Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action. , 1982, The Journal of clinical endocrinology and metabolism.
[98] H. Beck-Nielsen,et al. Prednisone increases the number of insulin receptors on monocytes from normal subjects. , 1980, The Journal of clinical endocrinology and metabolism.