The drug delivery technology landscape has become highly competitive and rapidly evolving. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Peptides, proteins and DNA-based therapeutics cannot be effectively delivered by conventional means. A Microsponges delivery system is a highly cross-linked, porous, polymeric microsphere, polymeric system consisting of porous microspheres that can entrap and release them into the skin over a long period of time. This delivery system provides extended release with reduced irritation, better tolerance, improved thermal, physical and chemical stability. The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non-toxic for a prolonged period In the present study various methods for preparation of microsponges drug delivery system are studied. Various advantages are also given which shows the importance of this method for the delivery of drugs over the other drug delivery system. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Microsponge technology offers entrapment of ingredients and is believed to contribute towards reduced side effects, improved stability, increased elegance, and enhanced formulation flexibility. In addition, numerous studies have confirmed that microsponge systems are non-irritating, nonmutagenic, non-allergenic, and non-toxic. Microsponges delivery technology is being used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens and prescription products. One of the best feature of microsponge is it is self-sterilizing. This review is focused on method of preparation, characterization and application of microsponge. Keywords: Microsponge, Control relaease, Target release, topical formulation, oral administration