Stat6 Is Necessary and Sufficient for IL-4’s Role in Th2 Differentiation and Cell Expansion
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W. Paul | Jinfang Zhu | Liying Guo | C. Watson | J. Hu‐Li | William E. Paul | Jinfang Zhu | Liying Guo | Jane Hu-Li | Cynthia J. Watson | Hutton Jane
[1] A Radbruch,et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. , 2000, Immunity.
[2] W. Paul,et al. Transient Inhibition of Interleukin 4 Signaling by T Cell Receptor Ligation , 2000, The Journal of experimental medicine.
[3] P. Thompson,et al. STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination. , 1998, Journal of immunology.
[4] Y. Yang,et al. JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes. , 1994, The Journal of biological chemistry.
[5] M. White,et al. IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells. , 1993, Science.
[6] William Arbuthnot Sir Lane,et al. Role of IRS-2 in insulin and cytokine signalling , 1995, Nature.
[7] W. Paul,et al. Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. , 1996, Immunity.
[8] W. Paul,et al. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis , 1995, Molecular and cellular biology.
[9] E. Liu,et al. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells , 1994, Nature.
[10] A. Rao,et al. T cell differentiation: a mechanistic view. , 2000, Current opinion in immunology.
[11] A. Weiss,et al. T cell antigen receptor signal transduction. , 1997, Current opinion in cell biology.
[12] G. Lienhard,et al. Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[13] W. Paul,et al. Interleukin 4 signals through two related pathways. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[14] Ling-mei Wang,et al. IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway. , 1996, Journal of immunology.
[15] W. Paul,et al. Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage , 1987, Nature.
[16] W. Paul,et al. Acquisition of lymphokine-producing phenotype by CD4+ T cells. , 1994, Annual review of immunology.
[17] U. Schindler,et al. A Gain-of-function Mutation in STAT6* , 2000, The Journal of Biological Chemistry.
[18] R. Kobayashi,et al. p62 dok : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells , 1997, Cell.
[19] W. Paul,et al. Survival and cytokine polarization of naive CD4+ T cells in vitro is largely dependent on exogenous cytokines , 2000, European journal of immunology.
[20] N. Tanaka,et al. The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. , 1996, Annual review of immunology.
[21] D. Baltimore,et al. Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok , 1997, Cell.
[22] M. Kaplan,et al. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. , 1996, Immunity.
[23] W. Paul,et al. FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. , 1998, Immunity.
[24] W. Paul,et al. An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth , 1994, Cell.
[25] W. Paul,et al. Characterization of a mobile Stat6 activation motif in the human IL-4 receptor. , 1998, Journal of immunology.
[26] J. Zamorano,et al. Regulation of apoptosis by tyrosine-containing domains of IL-4R alpha: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis. , 1998, Journal of immunology.
[27] J. Stavnezer,et al. Interaction of Stat6 and NF-κB: Direct Association and Synergistic Activation of Interleukin-4-Induced Transcription , 1998, Molecular and Cellular Biology.
[28] N. Reich,et al. Interleukin-4-induced STAT6 Recognizes and Activates a Target Site in the Promoter of the Interleukin-4 Receptor Gene* , 1996, The Journal of Biological Chemistry.
[29] S. Akira,et al. Essential role of Stat6 in IL-4 signalling , 1996, Nature.
[30] W. Paul,et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene , 1996, Nature.
[31] A. Sher,et al. Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile , 2000, The Journal of Immunology.
[32] L. Staudt,et al. T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[33] J. Bertoglio,et al. Interleukin-4 Induces Activation of Mitogen-activated Protein Kinase and Phosphorylation of Shc in Human Keratinocytes (*) , 1996, The Journal of Biological Chemistry.
[34] U. Schindler,et al. Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta. , 1998, Journal of immunology.
[35] H. Lee,et al. Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. , 1999, Immunity.
[36] T. S. P. S.,et al. GROWTH , 1924, Nature.
[37] K. Arai,et al. Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes , 1987, The Journal of experimental medicine.
[38] A. O’Garra,et al. The molecular basis of T helper 1 and T helper 2 cell differentiation. , 2000, Trends in cell biology.
[39] U. Schindler,et al. Synergistic Activation of the Germline ε Promoter Mediated by Stat6 and C/EBPβ , 1998, The Journal of Immunology.
[40] S. McKnight,et al. An interleukin-4-induced transcription factor: IL-4 Stat. , 1994, Science.
[41] Richard A Flavell,et al. The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells , 1997, Cell.
[42] R. Flavell,et al. Jak1 Expression Is Required for Mediating Interleukin-4-induced Tyrosine Phosphorylation of Insulin Receptor Substrate and Stat6 Signaling Molecules* , 1997, The Journal of Biological Chemistry.
[43] W. Paul,et al. The IL-4 receptor: signaling mechanisms and biologic functions. , 1999, Annual review of immunology.
[44] W. Ouyang,et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. , 1998, Immunity.