Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines.
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P. Le Pape | B. Baratte | S. Ruchaud | M. Sauvain | S. Bach | F. Pagniez | A. Vaisberg | M. Bazin | P. Marchand | M. Nourrisson | Carine Picot | Sophie Marhadour | Lizeth Bodero | G. Rivière | Denis Castillo Pareja
[1] K. Berka,et al. 2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro. , 2015, Bioorganic & medicinal chemistry letters.
[2] S. Rault,et al. Antileishmanial pharmacomodulation in 8-nitroquinolin-2(1H)-one series. , 2015, Bioorganic & medicinal chemistry.
[3] J. Sangshetti,et al. Antileishmanial drug discovery: comprehensive review of the last 10 years , 2015 .
[4] Vijay Luxami,et al. Recent advances in development of imidazo[1,2-a]pyrazines: synthesis, reactivity and their biological applications. , 2015, Organic & biomolecular chemistry.
[5] V. Kaplum,et al. Synthesis and biological evaluation of novel 2,3-disubstituted quinoxaline derivatives as antileishmanial and antitrypanosomal agents. , 2015, European journal of medicinal chemistry.
[6] F. Supek,et al. Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis , 2014, Chemical reviews.
[7] Kenneth Stuart,et al. Kinases as Druggable Targets in Trypanosomatid Protozoan Parasites , 2014, Chemical reviews.
[8] S. Gibbons,et al. Fruitful decade for antileishmanial compounds from 2002 to late 2011. , 2014, Chemical reviews.
[9] A. Megens,et al. Discovery of a potent, selective, and orally active phosphodiesterase 10A inhibitor for the potential treatment of schizophrenia. , 2014, Journal of medicinal chemistry.
[10] Xufeng Cao,et al. Design , Synthesis , and Structure − Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility , 2014 .
[11] Malcolm P. Huestis,et al. Sequential C3 and C5 Direct C–H Arylation of Imidazo[1,2‐a]pyrazines with (Hetero)aryl Bromides , 2014 .
[12] Nisha Singh,et al. Natural product based leads to fight against leishmaniasis. , 2014, Bioorganic & medicinal chemistry.
[13] L. Meijer,et al. Pharmacological Assessment Defines Leishmania donovani Casein Kinase 1 as a Drug Target and Reveals Important Functions in Parasite Viability and Intracellular Infection , 2013, Antimicrobial Agents and Chemotherapy.
[14] C. Jaffe,et al. Identification of a Secreted Casein Kinase 1 in Leishmania donovani: Effect of Protein over Expression on Parasite Growth and Virulence , 2013, PloS one.
[15] M. Bazin,et al. Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a]pyridine: expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines , 2013 .
[16] L. Meijer,et al. Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents. , 2012, European journal of medicinal chemistry.
[17] D. Rotella. Recent results in protein kinase inhibition for tropical diseases. , 2012, Bioorganic & medicinal chemistry letters.
[18] Nisha Singh,et al. Leishmaniasis: current status of available drugs and new potential drug targets. , 2012, Asian Pacific journal of tropical medicine.
[19] I. Grekov,et al. Leishmaniasis: prevention, parasite detection and treatment. , 2012, Current medicinal chemistry.
[20] M. Bazin,et al. An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via imidazo[1,2-a]pyridin-2-yl triflate through a Suzuki cross-coupling reaction-direct arylation sequence , 2012 .
[21] Ian H Gilbert,et al. Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3 , 2011, ChemMedChem.
[22] C. Nakamura,et al. Recent advances in leishmaniasis treatment. , 2011, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
[23] M. Walkinshaw,et al. Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines. , 2011, Bioorganic & medicinal chemistry letters.
[24] P. Pescher,et al. Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation , 2011, Cellular microbiology.
[25] S. Antinori,et al. Leishmaniasis: new insights from an old and neglected disease , 2011, European Journal of Clinical Microbiology & Infectious Diseases.
[26] M. Yadav,et al. Antileishmanial Agents: An Updated Review , 2011 .
[27] C. G. Mohan,et al. Mitogen-activated protein kinase 4 of Leishmania parasite as a therapeutic target. , 2010, European journal of medicinal chemistry.
[28] A. Addlagatta,et al. Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines. , 2010, European journal of medicinal chemistry.
[29] J. Aponte,et al. Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines. , 2010, Bioorganic & medicinal chemistry.
[30] V. Dubey,et al. Rational Approaches for Drug Designing Against Leishmaniasis , 2010, Applied biochemistry and biotechnology.
[31] A. Choudhary,et al. Leishmaniasis: current treatment strategies and future opportunities. , 2010 .
[32] P. Le Pape,et al. Infectivity of Leishmania mexicana Is Associated with Differential Expression of Protein Kinase C-Like Triggered during a Cell-Cell Contact , 2009, PloS one.
[33] P. Pescher,et al. Leishmania major MPK7 Protein Kinase Activity Inhibits Intracellular Growth of the Pathogenic Amastigote Stage , 2009, Eukaryotic Cell.
[34] Suman Gupta,et al. Design and synthesis of novel substituted quinazoline derivatives as antileishmanial agents. , 2009, Bioorganic & medicinal chemistry letters.
[35] David Lapointe,et al. Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds. , 2009, The Journal of organic chemistry.
[36] C. Musonda,et al. Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity. , 2009, Bioorganic & medicinal chemistry letters.
[37] K. Grant. Targeting the cell cycle in the pursuit of novel chemotherapies against parasitic protozoa. , 2008, Current pharmaceutical design.
[38] J. Galy,et al. Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine. , 2007, European journal of medicinal chemistry.
[39] M. Wiese. Leishmania MAP kinases--familiar proteins in an unusual context. , 2007, International journal for parasitology.
[40] L. Meijer,et al. Purification of CK1 by affinity chromatography on immobilised axin. , 2007, Protein expression and purification.
[41] H. Gornitzka,et al. Spirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae). , 2007, Journal of ethnopharmacology.
[42] B. Nare,et al. Inhibitors of casein kinase 1 block the growth of Leishmania major promastigotes in vitro. , 2006, International journal for parasitology.
[43] P. Le Pape,et al. Antileishmanial activities and mechanisms of action of indole-based azoles , 2006, Journal of enzyme inhibition and medicinal chemistry.
[44] Lin Tang,et al. Roscovitine Targets, Protein Kinases and Pyridoxal Kinase*[boxs] , 2005, Journal of Biological Chemistry.
[45] B. Tekwani,et al. Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues. , 2005, Bioorganic & medicinal chemistry.
[46] P. Le Pape,et al. Synthesis and Antileishmanial Activity of 3-(α-Azolylbenzyl)indoles , 2002 .
[47] F. Pagniez,et al. A new automatized fluorometric assay for anti-Leishmania drug screening , 2002 .
[48] N. Goyal,et al. In vitro cultivation and characterization of axenic amastigotes of Leishmania. , 2001, Trends in parasitology.
[49] G L Snyder,et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? , 2001, The Journal of biological chemistry.
[50] D. Sereno,et al. Axenically cultured amastigote forms as an in vitro model for investigation of antileishmanial agents , 1997, Antimicrobial agents and chemotherapy.
[51] D. Sereno,et al. Use of an enzymatic micromethod to quantify amastigote stage of Leishmania amazonensis in vitro , 1997, Parasitology Research.