A molecular atlas of cell types and zonation in the brain vasculature

[1]  C. Betsholtz,et al.  Preparation of single cell suspensions from the adult mouse lung , 2018 .

[2]  C. Betsholtz,et al.  Isolation of vessel-associated pdgfra -H2BGFP positive cells from murine brain , 2018 .

[3]  C. Betsholtz,et al.  Primary isolation of vascular cells from murine brain for single cell sequencing , 2018 .

[4]  A. van Oudenaarden,et al.  Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations , 2017, Nature Methods.

[5]  I. Amit,et al.  Single-cell spatial reconstruction reveals global division of labor in the mammalian liver , 2016, Nature.

[6]  A. Schlessinger,et al.  Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder , 2016, Cell.

[7]  Liqun He,et al.  Analysis of the brain mural cell transcriptome , 2016, Scientific Reports.

[8]  Jens Hjerling-Leffler,et al.  Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system , 2016, Science.

[9]  S. Linnarsson,et al.  Origin, fate and dynamics of macrophages at central nervous system interfaces , 2016, Nature Immunology.

[10]  R. Kelsh,et al.  Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish , 2016, Development.

[11]  M. Roussel,et al.  Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype. , 2016, Cancer cell.

[12]  David Attwell,et al.  What is a pericyte? , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[13]  Hans Clevers,et al.  Single-cell messenger RNA sequencing reveals rare intestinal cell types , 2015, Nature.

[14]  E. D. de Lange,et al.  Translational aspects of blood–brain barrier transport and central nervous system effects of drugs: From discovery to patients , 2015, Clinical pharmacology and therapeutics.

[15]  T. Maniatis,et al.  An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex , 2014, The Journal of Neuroscience.

[16]  A. Miyawaki,et al.  Visualizing the cell-cycle progression of endothelial cells in zebrafish. , 2014, Developmental biology.

[17]  P. Wong,et al.  Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid , 2014, Nature.

[18]  Cesare Furlanello,et al.  A promoter-level mammalian expression atlas , 2015 .

[19]  Åsa K. Björklund,et al.  Full-length RNA-seq from single cells using Smart-seq2 , 2014, Nature Protocols.

[20]  Åsa K. Björklund,et al.  Smart-seq2 for sensitive full-length transcriptome profiling in single cells , 2013, Nature Methods.

[21]  R. Sandberg,et al.  Efficient and Comprehensive Representation of Uniqueness for Next-Generation Sequencing by Minimum Unique Length Analyses , 2013, PloS one.

[22]  H. Augustin,et al.  Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF‐A and TGFβ2 in vascular abnormalization , 2012, The Journal of pathology.

[23]  G. E. Vates,et al.  A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β , 2012, Science Translational Medicine.

[24]  J. Sarkaria,et al.  Active Efflux of Dasatinib from the Brain Limits Efficacy against Murine Glioblastoma: Broad Implications for the Clinical Use of Molecularly Targeted Agents , 2012, Molecular Cancer Therapeutics.

[25]  C. Betsholtz,et al.  Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. , 2011, Developmental cell.

[26]  J. Holdway,et al.  Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. , 2011, Developmental cell.

[27]  P. Carmeliet,et al.  Differential Endothelial Transcriptomics Identifies Semaphorin 3G as a Vascular Class 3 Semaphorin , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[28]  K. Alitalo,et al.  Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries , 2009, Development.

[29]  Mark D. Robinson,et al.  edgeR: a Bioconductor package for differential expression analysis of digital gene expression data , 2009, Bioinform..

[30]  L. Lue,et al.  ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood–Brain Barrier for Aβ1–40 Peptides , 2009, The Journal of Neuroscience.

[31]  R. Deane,et al.  SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells , 2009, Nature Cell Biology.

[32]  Masahiko Hibi,et al.  Genetic dissection of neural circuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish , 2008, Proceedings of the National Academy of Sciences.

[33]  B. Zlokovic The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders , 2008, Neuron.

[34]  Melissa Hardy,et al.  The Tol2kit: A multisite gateway‐based construction kit for Tol2 transposon transgenesis constructs , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

[35]  Allan R. Jones,et al.  Genome-wide atlas of gene expression in the adult mouse brain , 2007, Nature.

[36]  T. Suda,et al.  Differentiation of arterial and venous endothelial cells and vascular morphogenesis. , 2006, Endothelium : journal of endothelial cell research.

[37]  P. Carmeliet,et al.  Bmx Tyrosine Kinase Has a Redundant Function Downstream of Angiopoietin and Vascular Endothelial Growth Factor Receptors in Arterial Endothelium , 2001, Molecular and Cellular Biology.

[38]  Peter B. Reiner,et al.  β‐Amyloid efflux mediated by p‐glycoprotein , 2001 .

[39]  B. Zlokovic,et al.  Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. , 1998, The Journal of clinical investigation.

[40]  David J. Anderson,et al.  Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4 , 1998, Cell.

[41]  K. Alitalo,et al.  Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries. , 1997, Circulation.

[42]  B R Johansson,et al.  Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. , 1997, Science.

[43]  J. Haines,et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.

[44]  N. Simionescu,et al.  Segmental differentiations of cell junctions in the vascular endothelium. The microvasculature , 1975, The Journal of cell biology.

[45]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[46]  R. Farinotti,et al.  Oatp1a4 and an L-thyroxine-sensitive transporter mediate the mouse blood-brain barrier transport of amyloid-β peptide. , 2013, Journal of Alzheimer's disease : JAD.

[47]  Rickard Sandberg,et al.  How to analyze gene expression using RNA-sequencing data. , 2012, Methods in molecular biology.

[48]  R. Deane,et al.  LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. , 2004, Neuron.

[49]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .