Analysis on Surveillance Data of Adverse Events Following Immunization in China,2012

Objective The study is to analyze the occurrence features of adverse event following immunization( AEFI) in China( not include Hong Kong Special Administrative Region,Macao Special Administrative Region and Taiwan sheng),2012,and to evaluate the implementation of AEFI information management system,and the immunization safety related to vaccines. Methods 2012 AEFI data were collected through the national AEFI information management system,which were reported before August 21,2013. The descriptive methodology was used in the study. Results 105,519 cases were collected from national AEFI information management system in 2012,which increased 38. 80% than in 2011. 2,824 counties reported AEFI,and the proportion of counties with reporting was 91. 21%. Proportion of cases reported within 48h was 98. 48%,and the proportion of cases investigated within 48h was 99. 14%. The ratio of male∶ female was 1. 39∶ 1. Cases ≤1 year old accounted for 74. 10%. Using 2012 vaccination doses collected from Chinese immunization information system,the estimated total AEFI incidence rate was 21. 71 per 100,000 doses,the estimated serious AEFI incidence rate was 0. 18 per 100,000 doses,the rare vaccine reaction incidence rate was 1. 62 per 100,000 doses,and the estimated serious rare vaccine reaction incidence rate was 0. 11 per 100,000 doses. In all vaccine reactions,the main symptoms of common vaccine reactions were fever, local swelling and indurations,the main diagnosis of rare vaccine reactions were anaphylactic rash and lymphadenitis of Bacilli Calmette-Guerin vaccines. Vaccine reactions were often occurred within 1d after vaccination. Of all AEFIs,99. 03% were recovered or got better. In 96 death cases,20 were rare vaccine reactions. Conclusions The sensitivity of national AEFI surveillance was increased greatly but still weak in some western provinces. AEFIs often occurred in young children,and within 1 day after vaccination. The estimated incidence rate of rare vaccine reactions of national immunization program vaccines were not higher than expected.