Effects of Antibiotics on Impacted Aquatic Environment Microorganisms

Due to their mass production and intense consumption in human medicine, veterinary, and aquaculture, antibiotics have been widely detected in different ecosystems, leading to a growing worldwide concern. These and their byproducts are being continuously discarded in natural ecosystems via excretion of human and animal urine and feces, also domestic and hospital effluents. Residues of these drugs can persist in natural environments through bioaccumulation due to their difficult biodegradation. Also, they have a gradual deposition in sediments, aquatic surfaces, and groundwater. Studies have shown the presence of these drugs in aquatic environments, which can trigger severe changes in the composition and structure of the bacterial community, such as the ability to develop and propagate genes resistant to these pollutants. In this context, this review aims to address the effects of the antibiotics on microorganisms present in impacted aquatic environments.

[1]  G. Wells,et al.  Microbial and Viral Communities and Their Antibiotic Resistance Genes Throughout a Hospital Wastewater Treatment System , 2020, Frontiers in Microbiology.

[2]  Shakeel Ahmad Dar,et al.  Concerns and Threats of Contamination on Aquatic Ecosystems , 2020, Bioremediation and Biotechnology.

[3]  Yucheng Cao,et al.  Contamination of antibiotic resistance genes (ARGs) in a typical marine aquaculture farm: source tracking of ARGs in reared aquatic organisms , 2020, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.

[4]  K. Wan,et al.  Co-selection and stability of bacterial antibiotic resistance by arsenic pollution accidents in source water. , 2019, Environment international.

[5]  Songhe Zhang,et al.  Profiles of ARGs and their relationships with antibiotics, metals and environmental parameters in vertical sediment layers of three lakes in China. , 2019, Journal of environmental management.

[6]  A. M. Eren,et al.  Disinfection exhibits systematic impacts on the drinking water microbiome , 2019, Microbiome.

[7]  K. Brandt,et al.  Heavy metal pollution and co-selection for antibiotic resistance: A microbial palaeontology approach. , 2019, Environment international.

[8]  J. Frye,et al.  Genetic Characterization of Antimicrobial-Resistant Escherichia coli Isolated from a Mixed-Use Watershed in Northeast Georgia, USA , 2019, International journal of environmental research and public health.

[9]  P. Padungtod,et al.  Knowledge, attitudes and practices of livestock and aquaculture producers regarding antimicrobial use and resistance in Vietnam , 2019, PloS one.

[10]  A. M. Motlagh,et al.  Detection and occurrence of indicator organisms and pathogens , 2019, Water environment research : a research publication of the Water Environment Federation.

[11]  S. Hossain,et al.  Antibiotic and heavy metal resistance genes in Aeromonas spp. isolated from marketed Manila Clam (Ruditapes philippinarum) in Korea , 2019, Journal of applied microbiology.

[12]  C. Delerue-Matos,et al.  Individual and mixture toxicity evaluation of three pharmaceuticals to the germination and growth of Lactuca sativa seeds. , 2019, The Science of the total environment.

[13]  A. Ramachandran,et al.  Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy , 2019, Microorganisms.

[14]  E. G. Stehling,et al.  Heavy metal resistance genes and plasmid-mediated quinolone resistance genes in Arthrobacter sp. isolated from Brazilian soils , 2019, Antonie van Leeuwenhoek.

[15]  E. Topp,et al.  Environmental risk assessment of antibiotics in agroecosystems: ecotoxicological effects on aquatic microbial communities and dissemination of antimicrobial resistances and antibiotic biodegradation potential along the soil-water continuum , 2019, Environmental Science and Pollution Research.

[16]  J. Thaden,et al.  Epidemiology and Mechanisms of Resistance of Extensively Drug Resistant Gram-Negative Bacteria , 2019, Antibiotics.

[17]  Wenjie Fu,et al.  Deciphering of microbial community and antibiotic resistance genes in activated sludge reactors under high selective pressure of different antibiotics. , 2019, Water research.

[18]  A. Mrozik,et al.  Antibiotics in the Soil Environment—Degradation and Their Impact on Microbial Activity and Diversity , 2019, Front. Microbiol..

[19]  M. T. dos Santos Correia,et al.  In vitro evaluation of mercury (Hg2+) effects on biofilm formation by clinical and environmental isolates of Klebsiella pneumoniae. , 2019, Ecotoxicology and environmental safety.

[20]  L. Stadler,et al.  Evaluating Antibiotic Resistance Gene Correlations with Antibiotic Exposure Conditions in Anaerobic Membrane Bioreactors. , 2019, Environmental science & technology.

[21]  Yanbo Zhou,et al.  Removal of antibiotic resistance genes and control of horizontal transfer risk by UV, chlorination and UV/chlorination treatments of drinking water , 2019, Chemical Engineering Journal.

[22]  Lei Liu,et al.  Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: A review , 2019, Environmental research.

[23]  Ewa Korzeniewska,et al.  Quantitative Occurrence of Antibiotic Resistance Genes among Bacterial Populations from Wastewater Treatment Plants Using Activated Sludge , 2019, Applied Sciences.

[24]  Pratyoosh Shukla,et al.  Antibiotics bioremediation: Perspectives on its ecotoxicity and resistance. , 2019, Environment international.

[25]  E. Korzeniewska,et al.  The emergence of antimicrobial resistance in environmental strains of the Bacteroides fragilis group. , 2019, Environment international.

[26]  M. C. Tomei,et al.  Performance of secondary wastewater treatment methods for the removal of contaminants of emerging concern implicated in crop uptake and antibiotic resistance spread: A review. , 2019, The Science of the total environment.

[27]  D. Larsson,et al.  Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments , 2019, Nature Communications.

[28]  P. Beaudeau,et al.  Waterborne Disease Outbreak Detection: A Simulation-Based Study , 2018, International journal of environmental research and public health.

[29]  Yongyou Hu,et al.  Research progress on distribution, migration, transformation of antibiotics and antibiotic resistance genes (ARGs) in aquatic environment , 2018, Critical reviews in biotechnology.

[30]  Yong-guan Zhu,et al.  Review of antibiotic resistance in China and its environment. , 2018, Environment international.

[31]  V. Ancona,et al.  Ecological effects of antibiotics on natural ecosystems: A review , 2018 .

[32]  I. Senta,et al.  Negative environmental impacts of antibiotic-contaminated effluents from pharmaceutical industries. , 2017, Water research.

[33]  S. Masunaga,et al.  Occurrence, distribution, ecological and resistance risks of antibiotics in surface water of finfish and shellfish aquaculture in Bangladesh. , 2017, Chemosphere.

[34]  E. Kristiansson,et al.  Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics. , 2017, Water research.

[35]  G. Zarfel,et al.  Tigecycline Resistant Klebsiella pneumoniae Isolated from Austrian River Water , 2017, International journal of environmental research and public health.

[36]  M. Touchon,et al.  Embracing the enemy: the diversification of microbial gene repertoires by phage-mediated horizontal gene transfer. , 2017, Current opinion in microbiology.

[37]  Tetsuya Hayashi,et al.  Antibiotic Resistance Profiling and Genotyping of Vancomycin-Resistant Enterococci Collected from an Urban River Basin in the Provincial City of Miyazaki, Japan , 2017 .

[38]  Lúcia Santos,et al.  Antibiotics in the aquatic environments: A review of the European scenario. , 2016, Environment international.

[39]  J. Kobayashi.  Search for New Bioactive Marine Natural Products and Application to Drug Development. , 2016, Chemical & pharmaceutical bulletin.

[40]  Carl-Fredrik Flach,et al.  An assay for determining minimal concentrations of antibiotics that drive horizontal transfer of resistance. , 2016, The Science of the total environment.

[41]  Petra F. G. Wolffs,et al.  Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer , 2016, Front. Microbiol..

[42]  German Calderón Rojas,et al.  Resistencia antimicrobiana: microorganismos más resistentes y antibióticos con menor actividad , 2016 .

[43]  J. Kuiaté,et al.  Complex secondary metabolites from Ludwigia leptocarpa with potent antibacterial and antioxidant activities. , 2016, Drug discoveries & therapeutics.

[44]  Thomas Backhaus,et al.  Ecotoxicological assessment of antibiotics: A call for improved consideration of microorganisms. , 2015, Environment international.

[45]  Paulo Henrique Pereira,et al.  A perspective on the potential risks of emerging contaminants to human and environmental health , 2015, Environmental Science and Pollution Research.

[46]  Miao Li,et al.  Occurrences and regional distributions of 20 antibiotics in water bodies during groundwater recharge. , 2015, The Science of the total environment.

[47]  E. Korzeniewska,et al.  The impact of a freshwater fish farm on the community of tetracycline-resistant bacteria and the structure of tetracycline resistance genes in river water. , 2015, Chemosphere.

[48]  Mirko S. Winkler,et al.  Sanitation safety planning : manual for safe use and disposal of wastewater, greywater and excreta , 2015 .

[49]  H. Budzinski,et al.  Toxicities of 48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France , 2016, Environmental Science and Pollution Research.

[50]  P. Giri,et al.  Ecotoxicological Aspects of Pharmaceuticals on Aquatic Environment , 2014 .

[51]  Silvia Berkner,et al.  Antibiotic resistance and the environment—there and back again , 2014, EMBO reports.

[52]  N. Woodford,et al.  Carbapenemase-producing Enterobacteriaceae and non-Enterobacteriaceae from animals and the environment: an emerging public health risk of our own making? , 2014, The Journal of antimicrobial chemotherapy.

[53]  A. Pitondo-Silva,et al.  Aquatic environments polluted with antibiotics and heavy metals: a human health hazard , 2014, Environmental Science and Pollution Research.

[54]  J. Ullman,et al.  pH and temperature effects on the hydrolysis of three β-lactam antibiotics: ampicillin, cefalotin and cefoxitin. , 2014, The Science of the total environment.

[55]  J. Fick,et al.  EU-wide monitoring survey on emerging polar organic contaminants in wastewater treatment plant effluents. , 2013, Water research.

[56]  M. Wong,et al.  Pharmaceuticals and personal care products (PPCPs): a review on environmental contamination in China. , 2013, Environment international.

[57]  E. Calbo,et al.  A review of the factors influencing antimicrobial prescribing. , 2013, Enfermedades infecciosas y microbiologia clinica.

[58]  Nádia Hortense Torres,et al.  OCORRÊNCIA, DESTINO E POTENCIAIS IMPACTOS DOS FÁRMACOS NO AMBIENTE , 2013 .

[59]  D Fatta-Kassinos,et al.  Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: a review. , 2013, Water research.

[60]  C. Manaia,et al.  Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review. , 2013, The Science of the total environment.

[61]  C. Prudêncio,et al.  &bgr;-Lactams: chemical structure, mode of action and mechanisms of resistance , 2013 .

[62]  P Verlicchi,et al.  Monitoring release of pharmaceutical compounds: occurrence and environmental risk assessment of two WWTP effluents and their receiving bodies in the Po Valley, Italy. , 2012, The Science of the total environment.

[63]  Gang Xu,et al.  Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China. , 2012, Journal of hazardous materials.

[64]  Tong Zhang,et al.  454 Pyrosequencing reveals bacterial diversity of activated sludge from 14 sewage treatment plants , 2011, The ISME Journal.

[65]  D. Lapworth,et al.  Emerging organic contaminants in groundwater: A review of sources, fate and occurrence. , 2012, Environmental pollution.

[66]  Marco Sonderegger,et al.  Environmental risk assessment for ancillary substances in biotechnological production of pharmaceuticals , 2012, Environmental toxicology and chemistry.

[67]  Kristin A Connors,et al.  Human pharmaceuticals in the aquatic environment: a review of recent toxicological studies and considerations for toxicity testing. , 2012, Reviews of environmental contamination and toxicology.

[68]  A. Coates,et al.  Novel classes of antibiotics or more of the same? , 2011, British journal of pharmacology.

[69]  P. Alvarez,et al.  Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the Haihe River Basin, China. , 2011, Environmental science & technology.

[70]  Surbhi Leekha,et al.  General Principles of Antimicrobial Therapy , 2011, Mayo Clinic proceedings.

[71]  R. Fanelli,et al.  Source, occurrence and fate of antibiotics in the Italian aquatic environment. , 2010, Journal of hazardous materials.

[72]  Luciano da Silva Momesso,et al.  Antibióticos: importância terapêutica e perspectivas para a descoberta e desenvolvimento de novos agentes , 2010 .

[73]  J. Martínez,et al.  Environmental pollution by antibiotics and by antibiotic resistance determinants. , 2009, Environmental pollution.

[74]  Klaus Kümmerer,et al.  Antibiotics in the aquatic environment--a review--part I. , 2009, Chemosphere.

[75]  Yong-Hwa Kim,et al.  Risk assessment of human antibiotics in Korean aquatic environment. , 2008, Environmental toxicology and pharmacology.

[76]  D. Aga,et al.  Comparison of the occurrence of antibiotics in four full-scale wastewater treatment plants with varying designs and operations. , 2007, Chemosphere.

[77]  A. Boxall,et al.  A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. , 2006, Chemosphere.

[78]  Z. Moldovan.  Occurrences of pharmaceutical and personal care products as micropollutants in rivers from Romania. , 2006, Chemosphere.

[79]  Ramunas Stepanauskas,et al.  Co-selection of antibiotic and metal resistance. , 2006, Trends in microbiology.

[80]  Roberto Andreozzi,et al.  Antibiotics in the environment: occurrence in Italian STPs, fate, and preliminary assessment on algal toxicity of amoxicillin. , 2004, Environmental science & technology.

[81]  K. Kümmerer,et al.  Standardized tests fail to assess the effects of antibiotics on environmental bacteria. , 2004, Water research.

[82]  M. Dezotti,et al.  Fármacos no meio ambiente , 2003 .

[83]  A. Alonso,et al.  Environmental selection of antibiotic resistance genes. , 2001, Environmental microbiology.

[84]  P. Lees,et al.  Antibiotic treatment for animals: effect on bacterial population and dosage regimen optimisation. , 2000, International journal of antimicrobial agents.

[85]  H. Wegener,et al.  Reducing the use of antimicrobial agents in animals and man. , 2000, Journal of medical microbiology.

[86]  J. Davison,et al.  Genetic exchange between bacteria in the environment. , 1999, Plasmid.

[87]  S. Sørensen,et al.  The Effect of Longterm Exposure to Mercury on the Bacterial Community in Marine Sediment , 1998, Current Microbiology.