Hypothalamic/pituitary sarcoidosis.

A patient is described with combined pulmonary and central nervous system sarcoidosis, including hypothalamic/pituitary involvement. Formal pituitary challenge testing was performed before steroid treatment and again eight months later. Diabetes insipidus, hyperprolactinemia, and anterior pituitary hormone deficiencies were demonstrated and did not improve significantly in response to steroids. Hypothalamic/pituitary involvement is a rare complication of sarcoidosis, the incidence of which may be under-reported.

[1]  B. Pentland,et al.  Central nervous system sarcoidosis. , 1985, The Quarterly journal of medicine.

[2]  F. Fyhrquist,et al.  Angiotensin converting enzyme in cerebrospinal fluid , 1985, Neurology.

[3]  F. Kerdel,et al.  Sarcoidosis. An updated review. , 1984, Journal of the American Academy of Dermatology.

[4]  J. Macfarlane.  Prognosis in sarcoidosis. , 1984, British medical journal.

[5]  S. Shalet,et al.  Hypothalamic-pituitary disease as the sole manifestation of sarcoidosis , 1982, Postgraduate medical journal.

[6]  H. Lebovitz,et al.  Disordered control of thirst in hypothalamic-pituitary sarcoidosis. , 1980, The New England journal of medicine.

[7]  H. Lebovitz,et al.  Hypothalamic insufficiency: the cause of hypopituitarism in sarcoidosis. , 1978, Annals of internal medicine.

[8]  K. Nakao,et al.  Serum prolactin levels in eighty patients with sarcoidosis , 1978, European journal of clinical investigation.

[9]  P. Delaney.  Neurologic manifestations in sarcoidosis: review of the literature, with a report of 23 cases. , 1977, Annals of internal medicine.

[10]  D. vesely,et al.  Partial hypopituitarism and possible hypothalamic involvement in sarcoidosis: report of a case and review of the literature. , 1977, The American journal of medicine.

[11]  R. W. Turkington,et al.  Hyperprolactinemia in sarcoidosis. , 1972, Annals of internal medicine.

[12]  Lawson Jg,et al.  TO-DAY'S DRUGS. TRIAMTERENE. , 1964 .

[13]  F. Robert.  Sarcoidosis of the central nervous system. Report of a case and review of the literature. , 1962, Archives of neurology.

[14]  Matson Dd,et al.  Hypopituitarism due to hypothalamic sarcoidosis. , 1959 .

[15]  S. Robbins,et al.  Sarcoid-like granulomata of the pituitary gland; a cause of pituitary insufficiency. , 1952, A.M.A. archives of internal medicine.

[16]  R. Deremee,et al.  Normal serum angiotensin converting enzyme activity in patients with newly diagnosed sarcoidosis. , 1984, Chest.

[17]  H. Schweisfurth,et al.  Assay and biochemical characterization of angiotensin-I-converting enzyme in cerebrospinal fluid. , 1984, Enzyme.

[18]  F. Katz,et al.  Hypothalamic sarcoidosis and hypopituitarism. , 1980, Hormone research.

[19]  C. Shealy,et al.  Hypothalamic-pituitary sarcoidosis: A report on four patients, one with prolonged remission of diabetes insipidus following steroid therapy☆ , 1961 .