CD uniformity budget for a 45-nm NV memory device requires the analysis and compensation of each single contributor factor. A dedicated simulation tool "CDU Predictor" helps to quantify the impact of main scanner and process factors for a comprehensive study of the CD Uniformity for an ideal flat wafer. However this analysis could under estimate the real CD distribution on a real production wafer if artefacts induced by thin-film effects and underling device topography significantly increase the contribution of the optical leveling-device to the total focus-error and hence spread the CD distribution for processes with low DOF. Such artefacts can be eliminated by application of an offset-map obtained by probing the mechanical top-surface of the resist-stack with an AirGauge (AirGaugeImprovedLEvelling, AGILE). The systematic variation of CD across the wafer, no matter whether due to fingerprints of the reticle, the device-topography, the track-process or the exposure-tool, can be mapped into dose-corrections for compensation (DoseMapper). We discuss an experimental case with a combination of both tools for an effective CD Uniformity optimization.