Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position.
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J. Vacca | S. Gardell | T. Tucker | S. D. Lewis | E. A. Lyle | T J Tucker | W C Lumma | J. Lynch | W. C. Lumma | J. Sisko | K. Dancheck | B. J. Lucas | E. Baskin | R. Woltmann | S. D. Appleby | I. Chen | A. Naylor-Olsen | J. A. Krueger | C. M. Cooper | J P Vacca | J J Lynch | I W Chen | S D Lewis | S J Gardell | B J Lucas | J T Sisko | E A Lyle | E P Baskin | R F Woltmann | S D Appleby | K B Dancheck | A M Naylor-Olsen | J A Krueger | C M Cooper | S. Lewis | S. Appleby