An overview of available metamaterial-based antenna for non-invasive hyperthermia cancer treatment

This paper presents the outcome of a literature review that an overview of various types of antenna and metamaterial applicator performance towards cancerous tissue or cell for non-invasive hyperthermia cancer treatment (NIHCT) procedure. From the review, it shows that when LHM lens integrated with an antenna, focusing capabilities of the antenna towards the cancerous area can be improved. However, current applicators have a poor focusing effect when directed towards the actual tumor area. In conjunction with that, this paper proposes a new design of modified applicator that is microstrip antenna integrated with left-handed metamaterial (LHM) lens. The antenna termed microstrip-LHM (M-LHM) lens antenna is proposed for use in NIHCT. It is expected to improve the focusing capabilities of an antenna which is used to kill the cancerous area and thus improve the hyperthermia cancer treatment procedure success rate. In addition, this paper provides an overview of heating techniques used in hyperthermia to enhance focusing capabilities and a few metamaterial advantages that can improve the focusing effect and reduced the hot-spots. Specific Absorption Rate (SAR) will be investigated to evaluate the focusing abilities of the proposed applicator using the SEMCAD X Solver.

[1]  Meng Li,et al.  Non-invasive breast cancer thermotherapy studies using conformal microstrip antennas , 2012, ISAPE2012.

[2]  A. M. Abbosh,et al.  Focusing techniques in breast cancer treatment using non-invasive microwave hyperthermia , 2015, 2015 International Symposium on Antennas and Propagation (ISAP).

[3]  Gang Wang,et al.  Conformal Hyperthermia of Superficial Tumor With Left-Handed Metamaterial Lens Applicator , 2012, IEEE Transactions on Biomedical Engineering.

[4]  V. R. Singh,et al.  Tumour ablation with focussed ultrasound , 1995, Proceedings of the First Regional Conference, IEEE Engineering in Medicine and Biology Society and 14th Conference of the Biomedical Engineering Society of India. An International Meet.

[5]  Gang Wang,et al.  Influence of source offset on breast tumor hyperthermia with Γ-shaped LHM lens applicator , 2010, 2010 International Conference on Microwave and Millimeter Wave Technology.

[6]  Win-Li Lin,et al.  Investigation of a Cylindrical Ultrasound Phased-Array with Multiple-Focus Scanning for Breast Tumor Thermal Therapy , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[7]  Gang Wang,et al.  Microwave heating by using flat LHM lens , 2008, 2008 International Workshop on Metamaterials.

[8]  Ilja Merunka,et al.  Utilization potential of balanced antipodal Vivaldi antenna for microwave hyperthermia treatment of breast cancer , 2014, The 8th European Conference on Antennas and Propagation (EuCAP 2014).

[9]  Young Joong Yoon,et al.  Planar array for non-invasive ultra-superficial hyperthermia applicator , 2015, 2015 International Workshop on Antenna Technology (iWAT).

[10]  W C M Numan,et al.  A printed Yagi–Uda antenna for application in magnetic resonance thermometry guided microwave hyperthermia applicators , 2017, Physics in medicine and biology.

[11]  Gang Wang,et al.  Hyperthermia of large superficial tumor with a flat LHM lens , 2012, 2012 IEEE/MTT-S International Microwave Symposium Digest.

[12]  S. P. Singh,et al.  Microstrip slot antenna for hyperthermia applications , 2015, 2015 IEEE Applied Electromagnetics Conference (AEMC).

[13]  Jun Hua,et al.  High gain patch antenna with broadband metamaterial lens , 2012, Proceedings of 2012 5th Global Symposium on Millimeter-Waves.

[14]  W. S. Chen,et al.  Heating Efficiency Improvement by Using A Spherically-Concaved Sectored Array in Focused Ultrasound Thermal Therapy , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[15]  N.K. Uzunoglu,et al.  Enhancing the Focusing Properties of a Prototype Non-Invasive Brain Hyperthermia System: a Simulation Study , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[16]  Meng Li,et al.  Microstrip near-field focusing for microwave non-invasive breast cancer thermotherapy , 2014, 2014 XXXIth URSI General Assembly and Scientific Symposium (URSI GASS).

[17]  Stuart Crozier,et al.  Microwave Hyperthermia for Breast Cancer Treatment Using Electromagnetic and Thermal Focusing Tested on Realistic Breast Models and Antenna Arrays , 2015, IEEE Transactions on Antennas and Propagation.

[18]  Mitsuru Uesaka,et al.  Design of invasive and non-invasive antennas for the combination of microwave-hyperthermia with radiation therapy , 2015, 2015 IEEE MTT-S 2015 International Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO).

[19]  Jian Li,et al.  Time Reversal Based Microwave Hyperthermia Treatment of Breast Cancer , 2005, Conference Record of the Thirty-Ninth Asilomar Conference onSignals, Systems and Computers, 2005..

[20]  G. Szigeti,et al.  Hyperthermia versus Oncothermia: Cellular Effects in Complementary Cancer Therapy , 2013, Evidence-based complementary and alternative medicine : eCAM.

[21]  Yonghui Tao,et al.  A New Hyperthermia Scheme with a Cylindrical LHM Lens , 2013 .

[22]  G. Tayeb,et al.  A metamaterial for directive emission. , 2002, Physical review letters.

[23]  O. D. Varona,et al.  A Comparison between Different Schemes of Microwave Cancer Hyperthermia Treatment by Means of Left-Handed Metamaterial Lenses , 2015 .

[24]  Hua Ma,et al.  A Novel High-Directivity Microstrip Patch Antenna Based on Zero-Index Metamaterial , 2009, IEEE Antennas and Wireless Propagation Letters.

[25]  T. Isernia,et al.  Focused microwave thermotherapy: A patient-specific numerical assessment of a non-invasive breast cancer treatment , 2012, 2012 6th European Conference on Antennas and Propagation (EUCAP).

[26]  T. Drizdal,et al.  Microstrip Applicator for Local Hyperthermia , 2007, 2007 International Conference on Electromagnetics in Advanced Applications.

[27]  Jui-Han Lu,et al.  Bandwidth enhancement design of single-layer slotted circular microstrip antennas , 2003 .

[28]  Manuel J. Freire,et al.  Metamaterial applicator for microwave hyperthermia , 2011, 2011 XXXth URSI General Assembly and Scientific Symposium.

[29]  Norlida Buniyamin,et al.  An overview of metamaterials used in applicators in hyperthermia cancer treatment procedure , 2017, 2017 International Conference on Electrical, Electronics and System Engineering (ICEESE).

[30]  O. Losito,et al.  E-field distribution improvement by new hyperthermia applicators , 2011, 2011 IEEE International Symposium on Medical Measurements and Applications.

[31]  Erdal Korkmaz,et al.  A Compact Microstrip Spiral Antenna Embedded in Water Bolus for Hyperthermia Applications , 2013 .

[32]  Norlida Buniyamin,et al.  An antenna with an embedded ebg structure for non invasive hyperthermia cancer treatment , 2014, 2014 IEEE Conference on Biomedical Engineering and Sciences (IECBES).

[33]  J. Vrba,et al.  Microwave thermotherapy: Study of hot-spots induced by electromagnetic surface waves , 2013, 2013 7th European Conference on Antennas and Propagation (EuCAP).

[34]  R. Garg,et al.  Microstrip Antenna Design Handbook , 2000 .

[35]  Erdal Korkmaz,et al.  A directive antenna array applicator for focused electromagnetic hyperthermia treatment of breast cancer , 2015, 2015 9th European Conference on Antennas and Propagation (EuCAP).

[36]  B. D. Veen,et al.  A computational study of ultra-wideband versus narrowband microwave hyperthermia for breast cancer treatment , 2006, IEEE transactions on microwave theory and techniques.

[37]  Antonio André Novotny,et al.  A new method for topology design of electromagnetic antennas in hyperthermia therapy , 2017 .

[38]  P. Kosmas,et al.  FDTD-based time reversal for microwave breast cancer Detection-localization in three dimensions , 2006, IEEE Transactions on Microwave Theory and Techniques.

[39]  Norlida Buniyamin,et al.  An overview of cancer thermal therapy technology based on different types of antenna exposure , 2013, 2013 International Conference on Electrical, Electronics and System Engineering (ICEESE).