Three distinct directions of intramural activation reveal non-uniform side-to-side electrical coupling of ventricular myocytes Short Title : Orthotropic Intramural Spread of LV Activation

A A A A A Auc uc uc uc uc uc uckl kl kl kl k k k an an an an an an and, d, d d d d d N N N N N N New ew ew ew ew ew ew ences es es es es es es Un Un Un Un Un Un Univ iv iv iv iv iv iver er er er er er ersi s s s s t y gy y t ssoc ate o esso o ys o ogy y gy y New Zealand ABSTRACT Background: The anisotropy of cardiac tissue is a key determinant of 3D electrical propagation

[1]  Andrew D McCulloch,et al.  Laminar fiber architecture and three-dimensional systolic mechanics in canine ventricular myocardium. , 1999, American journal of physiology. Heart and circulatory physiology.

[2]  B. Taccardi,et al.  Modeling ventricular excitation: axial and orthotropic anisotropy effects on wavefronts and potentials. , 2004, Mathematical biosciences.

[3]  A D McCulloch,et al.  Automated measurement of myofiber disarray in transgenic mice with ventricular expression of ras , 1998, The Anatomical record.

[4]  B. Taccardi,et al.  Simulating patterns of excitation, repolarization and action potential duration with cardiac Bidomain and Monodomain models. , 2005, Mathematical biosciences.

[5]  OmerBerenfeld,et al.  Purkinje-Muscle Reentry as a Mechanism of Polymorphic Ventricular Arrhythmias in a 3-Dimensional Model of the Ventricles , 1998 .

[6]  Purva Joshi,et al.  Surface imaging microscopy using an ultramiller for large volume 3D reconstruction of wax‐ and resin‐embedded tissues , 2007, Microscopy research and technique.

[7]  A. McCulloch,et al.  Relating myocardial laminar architecture to shear strain and muscle fiber orientation. , 2001, American journal of physiology. Heart and circulatory physiology.

[8]  J W Covell,et al.  Transverse shear along myocardial cleavage planes provides a mechanism for normal systolic wall thickening. , 1995, Circulation research.

[9]  Bruce H Smaill,et al.  Laminar Arrangement of Ventricular Myocytes Influences Electrical Behavior of the Heart , 2007, Circulation research.

[10]  A. M. Scher,et al.  Influence of Cardiac Fiber Orientation on Wavefront Voltage, Conduction Velocity, and Tissue Resistivity in the Dog , 1979, Circulation research.

[11]  Jian Huang,et al.  Fiberglass needle electrodes for transmural cardiac mapping , 2002, IEEE Transactions on Biomedical Engineering.

[12]  J E Saffitz,et al.  Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. , 1994, Circulation research.

[13]  Karl A. Tomlinson,et al.  Cardiac Microstructure: Implications for Electrical Propagation and Defibrillation in the Heart , 2002, Circulation research.

[14]  Bruno Taccardi,et al.  Epicardial and intramural excitation during ventricular pacing: effect of myocardial structure. , 2008, American journal of physiology. Heart and circulatory physiology.

[15]  O. Berenfeld,et al.  Shaping of a scroll wave filament by cardiac fibers. , 2001, Physical review. E, Statistical, nonlinear, and soft matter physics.

[16]  Bruce H Smaill,et al.  Automated imaging of extended tissue volumes using confocal microscopy , 2005, Microscopy research and technique.

[17]  Xavier Tricoche,et al.  Intramural activation and repolarization sequences in canine ventricles. Experimental and simulation studies. , 2005, Journal of electrocardiology.

[18]  V. Fast,et al.  Paradoxical Improvement of Impulse Conduction in Cardiac Tissue by Partial Cellular Uncoupling , 1997, Science.

[19]  P. Hunter,et al.  Mathematical model of geometry and fibrous structure of the heart. , 1991, The American journal of physiology.

[20]  Young,et al.  Extended confocal microscopy of myocardial laminae and collagen network , 1998, Journal of microscopy.

[21]  Alexander V Panfilov,et al.  Organization of Ventricular Fibrillation in the Human Heart , 2007, Circulation research.

[22]  L. Younes,et al.  Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure , 2005, Magnetic resonance in medicine.

[23]  A. Garfinkel,et al.  A simulation study of the effects of cardiac anatomy in ventricular fibrillation. , 2004, The Journal of clinical investigation.

[24]  P. Wolf,et al.  Transmural activations and stimulus potentials in three-dimensional anisotropic canine myocardium. , 1988, Circulation research.

[25]  J. Wikswo,et al.  Virtual electrodes in cardiac tissue: a common mechanism for anodal and cathodal stimulation. , 1995, Biophysical journal.

[26]  A Garfinkel,et al.  Scroll wave dynamics in a three-dimensional cardiac tissue model: roles of restitution, thickness, and fiber rotation. , 2000, Biophysical journal.

[27]  Quan Ni,et al.  Three-Dimensional Activation Mapping in Ventricular Muscle: Interpolation and Approximation of Activation Times , 1999, Annals of Biomedical Engineering.

[28]  P. Hunter,et al.  Laminar structure of the heart: ventricular myocyte arrangement and connective tissue architecture in the dog. , 1995, The American journal of physiology.

[29]  Sheng-Kwei Song,et al.  Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: quantification with diffusion tensor MRI. , 2005, American journal of physiology. Heart and circulatory physiology.

[30]  Y. Rudy,et al.  Basic mechanisms of cardiac impulse propagation and associated arrhythmias. , 2004, Physiological reviews.