Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma.

[1]  M. Sanderson,et al.  Regulation of airway smooth muscle cell contractility by Ca2+ signaling and sensitivity. , 2008, Proceedings of the American Thoracic Society.

[2]  T. Walseth,et al.  Calcium signaling in airway smooth muscle. , 2008, Proceedings of the American Thoracic Society.

[3]  L. Janssen,et al.  Ionic mechanisms and Ca2+ handling in airway smooth muscle , 2007, European Respiratory Journal.

[4]  J. Martin,et al.  Basic mechanisms of development of airway structural changes in asthma , 2006, European Respiratory Journal.

[5]  John W. Wilson,et al.  Airway remodelling in asthma: current understanding and implications for future therapies. , 2006, Pharmacology & therapeutics.

[6]  D. Cockcroft,et al.  Mechanisms of airway hyperresponsiveness. , 2006, The Journal of allergy and clinical immunology.

[7]  H. Sakai,et al.  Augmentation of endothelin-1-induced phosphorylation of CPI-17 and myosin light chain in bronchial smooth muscle from airway hyperresponsive rats. , 2006, Biological & pharmaceutical bulletin.

[8]  K. Chung,et al.  Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness. , 2006, European journal of pharmacology.

[9]  M. Tamm,et al.  Asthma ? Is it due to an abnormal Airway Smooth Muscle Cell ? , 2006 .

[10]  A. McWilliams,et al.  Bronchial thermoplasty for asthma. , 2006, American journal of respiratory and critical care medicine.

[11]  R. Panettieri,et al.  Airway smooth muscle as a regulator of immune responses and bronchomotor tone. , 2006, Clinics in chest medicine.

[12]  C. Lemière,et al.  Differences in airway remodeling between subjects with severe and moderate asthma. , 2005, The Journal of allergy and clinical immunology.

[13]  S. Peters,et al.  Airway remodeling contributes to the progressive loss of lung function in asthma: an overview. , 2005, The Journal of allergy and clinical immunology.

[14]  H. Sakai,et al.  Endothelin-1-induced translocation of RhoA is mediated by endothelin ETA receptors in rat bronchial smooth muscle , 2005 .

[15]  Miwa Misawa,et al.  Possible Involvement of CPI-17 in Augmented Bronchial Smooth Muscle Contraction in Antigen-Induced Airway Hyper-Responsive Rats , 2005, Molecular Pharmacology.

[16]  T. White,et al.  CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[17]  H. Sakai,et al.  Involvement of M3 muscarinic receptors in ACh-induced increase in membrane-associated RhoA of rat bronchial smooth muscle. , 2005, Biological & pharmaceutical bulletin.

[18]  H. Sakai,et al.  Involvement of RhoA-mediated Ca2+ sensitization in antigen-induced bronchial smooth muscle hyperresponsiveness in mice , 2005, Respiratory research.

[19]  I. Adcock,et al.  Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125. , 2005, European journal of pharmacology.

[20]  K. Abe,et al.  Involvement of p42/44 MAPK and RhoA protein in augmentation of ACh-induced bronchial smooth muscle contraction by TNF-alpha in rats. , 2004, Journal of applied physiology.

[21]  J. Sylvester The tone of pulmonary smooth muscle: ROK and Rho music? , 2004, American journal of physiology. Lung cellular and molecular physiology.

[22]  T. Ishizuka,et al.  8-Bromo-cAMP decreases the Ca2+ sensitivity of airway smooth muscle contraction through a mechanism distinct from inhibition of Rho-kinase. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[23]  Y. Chiba,et al.  The role of RhoA-mediated Ca2+ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness. , 2004, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

[24]  M. Bihl,et al.  Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. , 2004, The New England journal of medicine.

[25]  T. Tran,et al.  Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen‐specific , 2004, British journal of pharmacology.

[26]  C. G. McVicker,et al.  Proliferative aspects of airway smooth muscle. , 2004, The Journal of allergy and clinical immunology.

[27]  R. Panettieri,et al.  Bronchial hyperresponsiveness: insights into new signaling molecules. , 2004, Current opinion in pharmacology.

[28]  L. Janssen,et al.  Enhanced myosin phosphatase and Ca(2+)-uptake mediate adrenergic relaxation of airway smooth muscle. , 2004, American journal of respiratory cell and molecular biology.

[29]  R. Panettieri,et al.  IL‐13 enhances agonist‐evoked calcium signals and contractile responses in airway smooth muscle , 2003, British journal of pharmacology.

[30]  I. Adcock,et al.  Allergen‐induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N‐terminal kinase , 2003, British journal of pharmacology.

[31]  A. Somlyo,et al.  Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. , 2003, Physiological reviews.

[32]  S. Shore,et al.  Regulation of β-adrenergic responses in airway smooth muscle , 2003, Respiratory Physiology & Neurobiology.

[33]  M. Hershenson,et al.  Mitogenic signaling pathways in airway smooth muscle , 2003, Respiratory Physiology & Neurobiology.

[34]  Maree H. Poniris,et al.  PAR-2 activation, PGE2, and COX-2 in human asthmatic and nonasthmatic airway smooth muscle cells. , 2003, American journal of physiology. Lung cellular and molecular physiology.

[35]  Marketa Zvelebil,et al.  Phosphoinositide 3-kinase signalling--which way to target? , 2003, Trends in pharmacological sciences.

[36]  M. Berridge,et al.  Calcium: Calcium signalling: dynamics, homeostasis and remodelling , 2003, Nature Reviews Molecular Cell Biology.

[37]  J. Stankova,et al.  CysLT1 receptor upregulation by TGF-beta and IL-13, but not IL-4, is associated with bronchial smooth muscle cell proliferation in response to LTD4 , 2003 .

[38]  R. Panettieri,et al.  CD38‐cyclic ADP‐ribose‐mediated Ca2+ signaling contributes to airway smooth muscle hyperresponsiveness , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[39]  T. White,et al.  Intracellular calcium signaling through the CADPR pathway is agonist specific in porcine airway smooth muscle , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[40]  M. Laviolette,et al.  Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects. , 2002, American journal of physiology. Lung cellular and molecular physiology.

[41]  M. Roth,et al.  Interaction between glucocorticoids and β2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling , 2002, The Lancet.

[42]  Lewis C Cantley,et al.  The phosphoinositide 3-kinase pathway. , 2002, Science.

[43]  K. Druey,et al.  Heterotrimeric G protein signaling: role in asthma and allergic inflammation. , 2002, The Journal of allergy and clinical immunology.

[44]  G. De Sarro,et al.  Potential role of potassium channel openers in the treatment of asthma and chronic obstructive pulmonary disease. , 2002, Life sciences.

[45]  M. Tamm,et al.  Airway smooth muscle cell proliferation is increased in asthma. , 2001, American journal of respiratory and critical care medicine.

[46]  I. Kodama,et al.  Possible involvement of Rho kinase in Ca2+ sensitization and mobilization by MCh in tracheal smooth muscle. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[47]  G. De Sarro,et al.  Effects of non-bronchoconstrictive doses of inhaled propranolol on airway responsiveness to methacholine , 2001, European Journal of Clinical Pharmacology.

[48]  N. Hunt,et al.  ERK activation and mitogenesis in human airway smooth muscle cells. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[49]  A. Vatrella,et al.  Effect of inhaled heparin on water-induced bronchoconstriction in allergic asthmatics , 2001, European Journal of Clinical Pharmacology.

[50]  I. Hall Second messengers, ion channels and pharmacology of airway smooth muscle. , 2000, The European respiratory journal.

[51]  S. Thirstrup Control of airway smooth muscle tone. I--electrophysiology and contractile mediators. , 2000, Respiratory medicine.

[52]  A. Ammit,et al.  Activation of K-p21ras and N-p21ras, but not H-p21ras, is necessary for mitogen-induced human airway smooth-muscle proliferation. , 1999, American journal of respiratory cell and molecular biology.

[53]  J. Benovic,et al.  MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation. , 1999, American journal of physiology. Lung cellular and molecular physiology.

[54]  T. Vanden Hoek,et al.  Characterization of a Rac1 Signaling Pathway to Cyclin D1 Expression in Airway Smooth Muscle Cells* , 1999, The Journal of Biological Chemistry.

[55]  E. Chilvers,et al.  Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation. , 1999, American journal of physiology. Lung cellular and molecular physiology.

[56]  P. Vadiveloo,et al.  Glucocorticoids inhibit proliferation, cyclin D1 expression, and retinoblastoma protein phosphorylation, but not activity of the extracellular-regulated kinases in human cultured airway smooth muscle. , 1999, American journal of respiratory cell and molecular biology.

[57]  S. Patel,et al.  Molecular properties of inositol 1,4,5-trisphosphate receptors. , 1999, Cell calcium.

[58]  C. Hirshman,et al.  TNF-α upregulates Giα and Gqα protein expression and function in human airway smooth muscle cells. , 1999, American journal of physiology. Lung cellular and molecular physiology.

[59]  K. Hotta TNF-a upregulates Gia and Gqa protein expression and function in human airway smooth muscle cells , 1999 .

[60]  E. Chilvers,et al.  Platelet-derived growth factor-BB and thrombin activate phosphoinositide 3-kinase and protein kinase B: role in mediating airway smooth muscle proliferation. , 1998, Molecular pharmacology.

[61]  M. Yacoub,et al.  Expression of cyclo‐oxygenase‐2 in human airway smooth muscle is associated with profound reductions in cell growth , 1998, British journal of pharmacology.

[62]  S. Desrivières,et al.  Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability* , 1998, The Journal of Biological Chemistry.

[63]  R. Pestell,et al.  Catalytic activation of extracellular signal-regulated kinases induces cyclin D1 expression in primary tracheal myocytes. , 1998, American journal of respiratory cell and molecular biology.

[64]  C. Bertrand,et al.  Interleukin-1beta induces bradykinin B2 receptor gene expression through a prostanoid cyclic AMP-dependent pathway in human bronchial smooth muscle cells. , 1998, Molecular pharmacology.

[65]  G. Sieck,et al.  Role of cyclic ADP-ribose in the regulation of [Ca2+]i in porcine tracheal smooth muscle. , 1998, American journal of physiology. Cell physiology.

[66]  S. Marsico,et al.  Airways smooth muscle response to biological stimuli. , 1998, Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace.

[67]  A. Peacock,et al.  A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells. , 1996, The Biochemical journal.

[68]  J. Farley,et al.  Frequency modulation of acetylcholine-induced oscillations in Ca++ and Ca(++)-activated Cl- current by cAMP in tracheal smooth muscle. , 1996, The Journal of pharmacology and experimental therapeutics.

[69]  N. Noguchi,et al.  Requirement of Calmodulindependent Protein Kinase II in Cyclic ADP-ribose-mediated Intracellular Ca2+ Mobilization (*) , 1995, The Journal of Biological Chemistry.

[70]  T. Ohmori,et al.  A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization. , 1995, Journal of biochemistry.

[71]  T. Çelikel,et al.  Effect of inhaled heparin on methacholine-induced bronchial hyperreactivity. , 1995, Chest.

[72]  Andrew P. Somlyo,et al.  Signal transduction and regulation in smooth muscle , 1994, Nature.

[73]  K. Campbell,et al.  The ryanodine receptor/Ca2+ release channel. , 1993, The Journal of biological chemistry.

[74]  B. Fleischmann,et al.  Receptor-activated Ca influx in human airway smooth muscle: use of Ca imaging and perforated patch-clamp techniques. , 1993, The American journal of physiology.

[75]  M. Berridge Inositol trisphosphate and calcium signalling , 1993, Nature.

[76]  Hon Cheung Lee,et al.  Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose. , 1993, The Journal of biological chemistry.

[77]  M. Berridge,et al.  Inositol trisphosphate and calcium oscillations. , 2007, Advances in second messenger and phosphoprotein research.

[78]  S. Sapienza,et al.  Structural changes in the airways of sensitized brown Norway rats after antigen challenge. , 1991, The American review of respiratory disease.

[79]  M. Kotlikoff,et al.  Receptor‐activated calcium influx in human airway smooth muscle cells. , 1991, The Journal of physiology.

[80]  Nct Airway Obstruction and Inflammation , 1990 .

[81]  C. Pugliese,et al.  Calcium Ions and Airway Smooth Muscle Contraction , 1990 .

[82]  R. Coburn Airway Smooth Muscle in Health and Disease , 1989, Springer US.

[83]  T. Tomita Electrical Properties of Airway Smooth Muscle , 1989 .

[84]  M. Jenicek Méthodologie des essais cliniques des médicaments , 1982 .

[85]  R. Pierson,et al.  Mechanism of bronchoconstriction due to beta adrenergic blockade. Studies with practolol, propranolol, and atropine. , 1971, The Journal of allergy and clinical immunology.