Challenge to the simple paradigm that 'carcinogens' are 'mutagens' and to the in vitro and in vivo assays used to test the paradigm.

[1]  K. H. Clifton Comments on the evidence in support of the epigenetic nature of radiogenic initiation. , 1996, Mutation research.

[2]  P. Kirschmeier,et al.  Multistage carcinogenesis involves multiple genes and multiple mechanisms , 1984, Journal of cellular physiology. Supplement.

[3]  E. Farber Cell proliferation is not a major risk factor for cancer. , 1996, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[4]  S. Warren,et al.  Evaluation of the carcinogenic potential of 2,4-dinitrofluorobenzene and its implications regarding mutagenicity testing. , 1982, Carcinogenesis.

[5]  J. Ward,et al.  Cell proliferation not associated with carcinogenesis in rodents and humans. , 1993, Environmental health perspectives.

[6]  D. Boothman,et al.  Immediate X-ray-inducible responses from mammalian cells. , 1994, Radiation research.

[7]  A W Burgstahler Detroit fluoride conference. , 1966, Science.

[8]  J. Huff,et al.  Liver Carcinogenesis is Not a Predicted Outcome of Chemically Induced Hepatocyte Proliferation , 1993, Toxicology and industrial health.

[9]  B. Madhukar,et al.  Inhibition of gap junctional intercellular communication by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rat hepatocytes. , 1995, Carcinogenesis.

[10]  A. Wyllie,et al.  Cell death: the significance of apoptosis. , 1980, International review of cytology.

[11]  W. Thilly,et al.  N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[12]  J. Trosko 'A failed paradigm: carcinogenesis is more than mutagenesis'. , 1988, Mutagenesis.

[13]  C. Potten,et al.  Characterization of radiation-induced apoptosis in the small intestine and its biological implications. , 1994, International journal of radiation biology.

[14]  N. Suzuki,et al.  Suppression of Saccharin-induced Mutagenicity by Interferon-α in Human RSa Cells , 1995 .

[15]  T. Boulikas Control of DNA replication by protein phosphorylation. , 1994, Anticancer research.

[16]  J. Trosko,et al.  THE ROLE OF TUMOR PROMOTERS ON PHENOTYPIC ALTERATIONS AFFECTING INTERCELLULAR COMMUNICATION AND TUMORIGENESIS * , 1983, Annals of the New York Academy of Sciences.

[17]  G. Catravas,et al.  Membranes as sensitive targets in thymocyte apoptosis. , 1993, International journal of radiation biology.

[18]  J. Trosko,et al.  The role of modulated gap junctional intercellular communication in epigenetic toxicology. , 1994, Risk analysis : an official publication of the Society for Risk Analysis.

[19]  M. Arends,et al.  Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response. , 1995, British Journal of Cancer.

[20]  M. Karin,et al.  The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. , 1991, Biochimica et biophysica acta.

[21]  D. Hallahan,et al.  Biological consequences of gene regulation after ionizing radiation exposure. , 1991, Journal of the National Cancer Institute.

[22]  J. Simons,et al.  Inhibition of intercellular communication by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like PCBs in mouse hepatoma cells (Hepa1c1c7): involvement of the Ah receptor. , 1994, Toxicology and applied pharmacology.

[23]  J. Goodman,et al.  Hypomethylation of DNA: An epigenetic mechanism involved in tumor promotion , 1994, Molecular carcinogenesis.

[24]  P. Brookes Chemical Carcinogens and ras Gene Activation , 1989, Molecular carcinogenesis.

[25]  S. Fischer,et al.  Tumor‐promoting activity of 2,4‐dinitrofluorobenzene , 1995, International journal of cancer.

[26]  T. Sugimura,et al.  Mutation induction by okadaic acid, a protein phosphatase inhibitor, in CHL cells, but not in S. typhimurium. , 1991, Mutation research.

[27]  J. Trosko,et al.  Effect of temperature and exogenous dibutyryl c-AMP on the recovery of UV-induced ouabain-resistant Chinese hamster cells. , 1981, Mutation research.

[28]  T. Buttke,et al.  Redox regulation of programmed cell death in lymphocytes. , 1995, Free radical research.

[29]  W. Bursch,et al.  Cell death by apoptosis and its protective role against disease. , 1992, Trends in pharmacological sciences.

[30]  J. Trosko,et al.  Modulators of gap junction function: the scientific basis of epigenetic toxicology , 1990 .

[31]  G M Edelman,et al.  Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines , 1990, The Journal of cell biology.

[32]  B. Vogelstein,et al.  Participation of p53 protein in the cellular response to DNA damage. , 1991, Cancer research.

[33]  S. Orrenius,et al.  The role of intracellular oxidants in apoptosis. , 1995, Biochimica et biophysica acta.

[34]  C. Joe,et al.  In vitro inhibition of gap junctional intercellular communication by chemical carcinogens. , 1995, Toxicology.

[35]  P. Herrlich,et al.  Transcriptional and post-transcriptional responses to DNA-damaging agents. , 1994, Current opinion in cell biology.

[36]  Y. W. Lee,et al.  Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens , 1995, Molecular and cellular biology.