Traditionally, comprehensive process design has relied on a sound and insightful techno-economic analysis framework. In particular, once a base-case design is selected, further analysis is carried out to assess the environmental impact as well as possible process safety implications. Furthermore, limited modifications to the base-case design are typically carried out to concurrently address environmental and safety concerns. This sequential approach can thus lead to suboptimal process system designs when multiple objectives of profitability, sustainability, and safety are considered. Indeed, the simultaneous consideration of these objectives during the conceptual design phase of a project should lead to superior performance profiles. In the present work, a new approach for the incorporation of safety and sustainability considerations early enough during the conceptual design of the process is presented. This approach is based on extending the conventional return on investment (ROI) analysis to include pos...