Integrating the Science of Consciousness and Anesthesia

The nature and mechanism of human consciousness is emerging as one of the most important scientific and philosophical questions of the 21st century. Disregarded as a subject of serious inquiry throughout most of the 20th century, it has now regained legitimacy as a scientific endeavor. The investigation of consciousness and the mechanisms of general anesthesia have begun to converge. In the present article I provide an introduction to the study of consciousness, describe the neural correlates of consciousness that may be targets of general anesthetics, and suggest an integrated approach to the science of consciousness and anesthesia.

[1]  B. Libet,et al.  The neural time factor in conscious and unconscious events. , 2007, Ciba Foundation symposium.

[2]  R. Zatorre,et al.  Cortical Processing of Complex Auditory Stimuli during Alterations of Consciousness with the General Anesthetic Propofol , 2006, Anesthesiology.

[3]  George A Mashour,et al.  Cognitive Unbinding in Sleep and Anesthesia , 2005, Science.

[4]  Steven Laureys The neural correlate of (un)awareness: lessons from the vegetative state , 2005, Trends in Cognitive Sciences.

[5]  Helen A. Baghdoyan,et al.  Sleep, Anesthesiology, and the Neurobiology of Arousal State Control , 2005, Anesthesiology.

[6]  Anthony G. Hudetz,et al.  Volatile anesthetics disrupt frontal-posterior recurrent information transfer at gamma frequencies in rat , 2005, Neuroscience Letters.

[7]  G. Tononi,et al.  Breakdown of Cortical Effective Connectivity During Sleep , 2005, Science.

[8]  George A Mashour,et al.  Mechanisms of general anesthesia: from molecules to mind. , 2005, Best practice & research. Clinical anaesthesiology.

[9]  Olga A Imas,et al.  Volatile Anesthetics Enhance Flash-induced &ggr; Oscillations in Rat Visual Cortex , 2005, Anesthesiology.

[10]  M. Alkire,et al.  Does the Amygdala Mediate Anesthetic-induced Amnesia?: Basolateral Amygdala Lesions Block Sevoflurane-induced Amnesia , 2005, Anesthesiology.

[11]  M. Mishina,et al.  Effect of N-methyl-d-aspartate Receptor &egr;1 Subunit Gene Disruption of the Action of General Anesthetic Drugs in Mice , 2005, Anesthesiology.

[12]  P. Sebel,et al.  Functional connectivity changes with concentration of sevoflurane anesthesia , 2005, Neuroreport.

[13]  Leslie S. Prichep,et al.  The Anesthetic Cascade: A Theory of How Anesthesia Suppresses Consciousness , 2005, Anesthesiology.

[14]  T. Yamakura,et al.  Action of Isoflurane on the Substantia Gelatinosa Neurons of the Adult Rat Spinal Cord , 2005, Anesthesiology.

[15]  G. Tononi An information integration theory of consciousness , 2004, BMC Neuroscience.

[16]  B. Antkowiak,et al.  Propofol and Sevoflurane Depress Spinal Neurons In Vitro via Different Molecular Targets , 2004, Anesthesiology.

[17]  B. Antkowiak,et al.  Molecular and neuronal substrates for general anaesthetics , 2004, Nature Reviews Neuroscience.

[18]  Gerhard Rammes,et al.  Isoflurane Reduces Glutamatergic Transmission in Neurons in the Spinal Cord Superficial Dorsal Horn: Evidence for a Presynaptic Site of an Analgesic Action , 2004, Anesthesia and analgesia.

[19]  George A Mashour,et al.  Consciousness Unbound: Toward a Paradigm of General Anesthesia , 2004, Anesthesiology.

[20]  B. Rehberg,et al.  Monitoring of Immobility to Noxious Stimulation during Sevoflurane Anesthesia Using the Spinal H-reflex , 2004, Anesthesiology.

[21]  Olaf Sporns,et al.  Measuring information integration , 2003, BMC Neuroscience.

[22]  B. Baars Current concepts of consciousness with some implications for anesthesia , 2003 .

[23]  K. Miller,et al.  Mechanisms of actions of inhaled anesthetics. , 2003, The New England journal of medicine.

[24]  C. Koch,et al.  A framework for consciousness , 2003, Nature Neuroscience.

[25]  F. Plum,et al.  Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain. , 2002, Brain : a journal of neurology.

[26]  Geraint Rees,et al.  Neural correlates of consciousness in humans , 2002, Nature Reviews Neuroscience.

[27]  Christopher C. Pack,et al.  Dynamic properties of neurons in cortical area MT in alert and anaesthetized macaque monkeys , 2001, Nature.

[28]  R. Eckenhoff Promiscuous ligands and attractive cavities: how do the inhaled anesthetics work? , 2001, Molecular interventions.

[29]  E. John,et al.  Invariant Reversible QEEG Effects of Anesthetics , 2001, Consciousness and Cognition.

[30]  E. Kochs,et al.  Isoflurane Blocks Synaptic Plasticity in the Mouse Hippocampus , 2001, Anesthesiology.

[31]  J. H. Fallon,et al.  Toward a Unified Theory of Narcosis: Brain Imaging Evidence for a Thalamocortical Switch as the Neurophysiologic Basis of Anesthetic-Induced Unconsciousness , 2000, Consciousness and Cognition.

[32]  S Laureys,et al.  Restoration of thalamocortical connectivity after recovery from persistent vegetative state , 2000, The Lancet.

[33]  H Shimizu,et al.  Suppression of gamma activity in the human medial temporal lobe by sevoflurane anesthesia , 2000, Neuroreport.

[34]  C. Gray The Temporal Correlation Hypothesis of Visual Feature Integration Still Alive and Well , 1999, Neuron.

[35]  Alan C. Evans,et al.  Brain Mechanisms of Propofol-Induced Loss of Consciousness in Humans: a Positron Emission Tomographic Study , 1999, The Journal of Neuroscience.

[36]  C. Phillips,et al.  Impaired Effective Cortical Connectivity in Vegetative State: Preliminary Investigation Using PET , 1999, NeuroImage.

[37]  F. Varela,et al.  Perception's shadow: long-distance synchronization of human brain activity , 1999, Nature.

[38]  T. Sakai,et al.  The effect of ketamine on clinical endpoints of hypnosis and EEG variables during propofol infusion , 1999, Acta anaesthesiologica Scandinavica.

[39]  S. Hameroff,et al.  Anesthesia, consciousness and hydrophobic pockets--a unitary quantum hypothesis of anesthetic action. , 1998, Toxicology letters.

[40]  Thomas Metzinger,et al.  Conference on Neural Correlates of Consciousness: Empirical and Conceptual Questions , 1998, Consciousness and Cognition.

[41]  Karl J. Friston,et al.  Psychophysiological and Modulatory Interactions in Neuroimaging , 1997, NeuroImage.

[42]  N. Kanwisher,et al.  The Fusiform Face Area: A Module in Human Extrastriate Cortex Specialized for Face Perception , 1997, The Journal of Neuroscience.

[43]  M. Mehta,et al.  Spinal Cord Motoneuron Excitability during Isoflurane and Nitrous Oxide Anesthesia , 1997, Anesthesiology.

[44]  R. Penrose,et al.  Conscious Events as Orchestrated Space-Time Selections , 1996 .

[45]  H. Flohr Sensations and brain processes , 1995, Behavioural Brain Research.

[46]  H. Flohr,et al.  An information processing theory of anaesthesia , 1995, Neuropsychologia.

[47]  A. Dale,et al.  Visual motion aftereffect in human cortical area MT revealed by functional magnetic resonance imaging , 1995, Nature.

[48]  C. Koch,et al.  Are we aware of neural activity in primary visual cortex? , 1995, Nature.

[49]  J. Bogen,et al.  On the Neurophysiology of Consciousness: 1. An Overview , 1995, Consciousness and Cognition.

[50]  R. Llinás,et al.  Human oscillatory brain activity near 40 Hz coexists with cognitive temporal binding. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[51]  B. Baars,et al.  A Neural Attentional Model for Access to Consciousness: A Global Workspace Perspective , 1993 .

[52]  K Tanaka,et al.  Neuronal mechanisms of object recognition. , 1993, Science.

[53]  E. Capaldi,et al.  The organization of behavior. , 1992, Journal of applied behavior analysis.

[54]  C. Koch,et al.  Does anesthesia cause loss of consciousness? , 1991, Trends in Neurosciences.

[55]  N. Logothetis,et al.  Neuronal correlates of subjective visual perception. , 1989, Science.

[56]  R. M. Siegel,et al.  Foundations of Cognitive Science , 1990, Journal of Cognitive Neuroscience.

[57]  Drew McDermott,et al.  A critique of pure reason 1 , 1987, The Philosophy of Artificial Intelligence.

[58]  N. P. Franks,et al.  Do general anaesthetics act by competitive binding to specific receptors? , 1984, Nature.

[59]  D C Van Essen,et al.  Functional properties of neurons in middle temporal visual area of the macaque monkey. I. Selectivity for stimulus direction, speed, and orientation. , 1983, Journal of neurophysiology.

[60]  T. Yamamura,et al.  Fast Oscillatory EEG Activity Induced by Analgesic Concentrations of Nitrous Oxide in Man , 1981, Anesthesia and analgesia.

[61]  H. Beecher Anesthesia's Second Power: Probing the Mind. , 1947, Science.

[62]  H. Meyer Zur Theorie der Alkoholnarkose , 1899, Archiv für experimentelle Pathologie und Pharmakologie.

[63]  Michael T Alkire,et al.  General anesthesia and the neural correlates of consciousness. , 2005, Progress in brain research.

[64]  Steven Laureys,et al.  The boundaries of consciousness : neurobiology and neuropathology , 2005 .

[65]  L. Cauller,et al.  The neural basis of the behaviorally relevant N1 component of the somatosensory-evoked potential in SI cortex of awake monkeys: evidence that backward cortical projections signal conscious touch sensation , 2004, Experimental Brain Research.

[66]  E. Thompson,et al.  Are There Neural Correlates of Consciousness , 2004 .

[67]  Stanislas Dehaene,et al.  The cognitive neuroscience of consciousness , 2001 .

[68]  D. Chalmers What is a Neural Correlate of Consciousness , 2000 .

[69]  D. Chalmers,et al.  Toward a Science of Consciousness III : the third Tucson discussions and debates , 1999 .

[70]  Alwyn C. Scott,et al.  Toward a Science of Consciousness II: The 1996 Tucson Discussions and Debates , 1998 .

[71]  N. Block,et al.  The nature of consciousness : philosophical debates , 1997 .

[72]  Alwyn C. Scott,et al.  Toward a science of consciousness: The first Tucson discussions and debates , 1996 .

[73]  Christoph von der Malsburg,et al.  The Correlation Theory of Brain Function , 1994 .

[74]  Joel L. Davis,et al.  Large-Scale Neuronal Theories of the Brain , 1994 .

[75]  N W Daw,et al.  The role of NMDA receptors in information processing. , 1993, Annual review of neuroscience.