Antioxidant and Antidiabetic Properties of Vitex nigundo L. Leaves

Vitex Nigundo Linn. is credited with important medicinal activities such as antioxidant, anti-inflammatory, analgesic, anticonvulsant etc. The purpose of the presents study was to assess the therapy effect of V. Nigundo leaves extract on glucose level, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, SGPT and SGOT in blood serum of diabetic animals. Ethyl alcohol extract of V. Nigundo leaves in doses of 200 and 300 mgkg-1 body weights was daily administered orally by gavages to mice for 21 days to evaluate their antihyperglycemic and antihyperlipidemic effects on normal and streptozotocin-induced diabetic mice. Ethyl alcohol extract of V. Nigundo leaves in doses of 300 mgkg-1 body weights showed (P<0.01) more significant activity than the ethyl alcohol extract of V. Nigundo leaves in doses of 200 mgkg-1 body weights. The study validates scientifically the widely claimed use of V. Nigundo leaves as an ethnomedicine to treat diabetes mellitus.

[1]  Muhammad Ali Khan,et al.  Evaluation of antioxidant and anticancer properties of the seed extracts of Syzygium fruticosum Roxb. growing in Rajshahi, Bangladesh , 2013, BMC Complementary and Alternative Medicine.

[2]  G. Yeh,et al.  Complementary and Alternative Medicine Therapies for Diabetes: A Clinical Review , 2010, Clinical Diabetes.

[3]  P. Shukla,et al.  New antifungal flavonoid glycoside from Vitex negundo. , 2007, Bioorganic & medicinal chemistry letters.

[4]  D. Ghosh,et al.  Comparative Study on Antihyperglycemic and Antihyperlipidemic Effects of Separate and Composite Extract of Seed of Eugenia Jambolana and Root of Musa Paradisiaca in Streptozotocin-Induced Diabetic Male Albino Rat , 2006 .

[5]  R. Yanardag,et al.  Effect of vanadyl sulfate on the status of lipid parameters and on stomach and spleen tissues of streptozotocin-induced diabetic rats. , 2006, Pharmacological research.

[6]  L. Pari,et al.  Bmc Complementary and Alternative Medicine Antihyperlipidemic and Antiperoxidative Effect of Diasulin, a Polyherbal Formulation in Alloxan Induced Hyperglycemic Rats , 2004 .

[7]  D. Ghosh,et al.  Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats. , 2004, Journal of ethnopharmacology.

[8]  W. Ratnasooriya,et al.  Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo. , 2003, Journal of ethnopharmacology.

[9]  A. Goswami,et al.  Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. , 2002, The Biochemical journal.

[10]  L. al-Shamaony,et al.  Hypoglycaemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals. , 1994, Journal of ethnopharmacology.

[11]  S. Vikas,et al.  Phytochemical Investigation and Hypoglycemic effects of Vitex negundo , 2013 .

[12]  M. Firoz,et al.  Antitumor and antibacterial activity of a crude methanol leaf extract of Vitex negundo L. , 2013 .

[13]  S. Georgieva,et al.  TOTAL PHENOLIC AND TOTAL FLAVONOID CONTENTS , ANTIOXIDANT CAPACITY AND BIOLOGICAL CONTAMINANTS IN MEDICINAL HERBS , 2011 .

[14]  Shrinivas S. Sharma,et al.  Evaluation of anticancer activity of Vitex negundo in experimental animals: an in vitro & in vivo study. , 2009 .

[15]  K. Pandey,et al.  Plant polyphenols as dietary antioxidants in human health and disease , 2009, Oxidative medicine and cellular longevity.

[16]  R. Gupta,et al.  Effect of Vitex negundo on oxidative stress , 2005 .