Alien hand sign.

Usage of the term "alien hand sign" is reviewed in 20 published cases. It refers to apparently purposeful, upper-extremity movements that the patient reports are beyond his/her control. Lesions were found in medial frontal cortex and/or the corpus callosum with presentation being unilateral and transient, unless bilateral cortical and subcortical structures were involved. There was a high co-occurrence of speech hesitation, limb dyspraxia, tactile dysnomia, muscle weakness, and grasp reflex on the alien side. Five behavioral manifestations of alien movement have been described, with grasping movements and intermanual conflict being the most common. Two manifestations, exaggerated ataxic automatisms and drifting movements, likely represent other types of movement disorders. Dysfunction of the supplementary motor area and related structures has been implicated, but the exact causal mechanism remains uncertain.

[1]  T. Feinberg,et al.  Two alien hand syndromes , 1992, Neurology.

[2]  J. Hanakita,et al.  Left alien hand sign and mirror writing after left anterior cerebral artery infarction. , 1991, Surgical neurology.

[3]  S. Couch,et al.  CT and MR findings in a patient with alien hand sign. , 1990, AJNR. American journal of neuroradiology.

[4]  G. Goldberg,et al.  The Alien Hand Sign: Localization, Lateralization and Recovery , 1990 .

[5]  Y. Tanaka,et al.  Diagonistic dyspraxia , 1990, Neurology.

[6]  R. Leiguarda,et al.  Anterior callosal haemorrhage. A partial interhemispheric disconnection syndrome. , 1989, Brain : a journal of neurology.

[7]  R. Latchaw,et al.  The Alien Hand Syndrome. Clinical and Postmortem Findings , 1989 .

[8]  F. Mastaglia,et al.  "Alien hand" and loss of bimanual coordination after dominant anterior cerebral artery territory infarction. , 1988, Journal of neurology, neurosurgery, and psychiatry.

[9]  E. Ross,et al.  Left‐handed mirror writing following right anterior cerebral artery infarction , 1988, Neurology.

[10]  K M Heilman,et al.  Apraxia and the supplementary motor area. , 1986, Archives of neurology.

[11]  D. Levine,et al.  Opticosensory ataxia and alien hand syndrome after posterior cerebral artery territory infarction , 1986, Neurology.

[12]  F. Lhermitte.  'Utilization behaviour' and its relation to lesions of the frontal lobes. , 1983, Brain : a journal of neurology.

[13]  P. Roland,et al.  Regional cerebral blood flow changes in cortex and basal ganglia during voluntary movements in normal human volunteers. , 1982, Journal of neurophysiology.

[14]  G. Goldberg,et al.  Medial frontal cortex infarction and the alien hand sign. , 1981, Archives of neurology.

[15]  M. Alexander,et al.  The aphasia syndrome of stroke in the left anterior cerebral artery territory. , 1980, Archives of neurology.

[16]  M. Gazzaniga,et al.  Cerebral commissurotomy for control of intractable seizures , 1977, Neurology.

[17]  H. Nelson.  A Modified Card Sorting Test Sensitive to Frontal Lobe Defects , 1976, Cortex.

[18]  J. Barbizet,et al.  [Interhemispheric disconnection syndrome of ischemic origin]. , 1974, Revue neurologique.

[19]  C. Jedynak,et al.  [Disorders of interhemispheric transfer (callosal disonnection). 3 cases of tumor of the corpus callosum. The strange hand sign]. , 1972, Revue neurologique.

[20]  H E ROSVOLD,et al.  A continuous performance test of brain damage. , 1956, Journal of consulting psychology.

[21]  A. Akelaitis.  Studies on the corpus callosum : IV. Diagonistic dyspraxia in epileptics following partial and complete section of the corpus callosum , 1945 .

[22]  P. Gasquoine.  Bilateral alien hand signs following destruction of the medial frontal cortices , 1993 .

[23]  H. Freund,et al.  Premotor area and preparation of movement. , 1990, Revue neurologique.

[24]  B. Hyland,et al.  What is the role of the supplementary motor area in movement initiation? , 1989, Progress in brain research.

[25]  R. Leiguarda,et al.  Disconnection syndrome in a right-handed patient with right hemispheric speech dominance. , 1988, European neurology.

[26]  P. Roland,et al.  Supplementary motor area and other cortical areas in organization of voluntary movements in man. , 1980, Journal of neurophysiology.

[27]  D. Gronwall,et al.  The psychological effects of concussion , 1974 .

[28]  J Barbizet,et al.  Clinical and psychometrical study of a patient with memory disturbances. , 1968, International journal of neurology.