Flt 3 ligand, MGDF, Epo and G-CSF enhance ex vivo expansion of hematopoietic cell compartments in the presence of SCF, IL-3 and IL-6

[1]  E..  Modulation of Megakaryocytopoiesis by Thrombopoietin : The c-Mpl Ligand , 2000 .

[2]  H. Mckenna,et al.  Effect of flt 3 Ligand on the Ex Vivo Expansion of Human CD 34 + Hematopoietic Progenitor Cells , 2000 .

[3]  N. Gorin,et al.  The ex vivo expansion capacity of normal human bone marrow cells is dependent on experimental conditions: role of the cell concentration, serum and CD34+ cell selection in stroma-free cultures. , 1997, Hematology and cell therapy.

[4]  David A. Williams,et al.  Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy , 1996, Nature Medicine.

[5]  G. Crooks,et al.  Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population. , 1996, Blood.

[6]  S. Jacobsen,et al.  Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro. , 1996, Blood.

[7]  K. Kaushansky,et al.  Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. , 1996, Blood.

[8]  J M Piret,et al.  Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin , 1996, The Journal of experimental medicine.

[9]  C. Hannum,et al.  Flt3 ligand induces proliferation of quiescent human bone marrow CD34+CD38- cells and maintains progenitor cells in vitro. , 1996, Blood.

[10]  W S Alexander,et al.  Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. , 1996, Blood.

[11]  C. Eaves,et al.  Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[12]  V. Broudy,et al.  Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. , 1996, Experimental hematology.

[13]  Lesley J. Murray,et al.  Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin- primitive progenitor cells. , 1996, Blood.

[14]  H. Lu,et al.  Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor. , 1995, Blood.

[15]  S. Kosak,et al.  Evaluation of ex vivo expansion potential of cord blood and bone marrow hematopoietic progenitor cells using cell tracking and limiting dilution analysis. , 1995, Blood.

[16]  V. Broudy,et al.  Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. , 1995, Blood.

[17]  R. Schreiber,et al.  In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. , 1994, Blood.

[18]  Peter W. Zandstra,et al.  Expansion of Hematopoietic Progenitor Cell Populations in Stirred Suspension Bioreactors of Normal Human Bone Marrow Cells , 1994, Bio/Technology.

[19]  V. Broudy,et al.  Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin , 1994, Nature.

[20]  H. Mckenna,et al.  Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells. , 1994, Blood.

[21]  T. Mcclanahan,et al.  Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs , 1994, Nature.

[22]  J. Mary,et al.  Interleukin 2 interacts with myeloid growth factors in serum‐free long‐term bone marrow culture , 1994, British journal of haematology.

[23]  M. Ratajczak,et al.  STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[24]  T. Farrah,et al.  Molecular cloning of a ligand for the flt3 flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells , 1993, Cell.

[25]  W. Vainchenker,et al.  A murine stromal cell line allows the proliferation of very primitive human CD34++/CD38- progenitor cells in long-term cultures and semisolid assays , 1993 .

[26]  M. Ogawa,et al.  Differentiation and proliferation of hematopoietic stem cells. , 1993, Blood.

[27]  C. Eaves,et al.  Alternative mechanisms with and without steel factor support primitive human hematopoiesis. , 1993, Blood.

[28]  Eleftherios T. Papoutsakis,et al.  Expansion of Primitive Human Hematopoietic Progenitors in a Perfusion Bioreactor System with IL-3, IL-6, and Stem Cell Factor , 1993, Bio/Technology.

[29]  R. Hoffman,et al.  Long-term generation and expansion of human primitive hematopoietic progenitor cells in vitro. , 1993, Blood.

[30]  M. Moore,et al.  Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential. , 1993, Blood.

[31]  S. Heimfeld,et al.  Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, interleukin-1 beta (IL-1 beta), IL-6, IL-3, interferon-gamma, and erythropoietin. , 1993, Blood.

[32]  S. Emerson,et al.  Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures. , 1993, Blood.

[33]  L. To,et al.  Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage. , 1992, Blood.

[34]  M. Ogawa,et al.  Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. , 1992, Blood.

[35]  M. Ogawa,et al.  Growth factor requirements for survival in G0 and entry into the cell cycle of primitive human hemopoietic progenitors. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[36]  G. Demetri,et al.  Granulocyte colony-stimulating factor and its receptor. , 1991, Blood.

[37]  N. Nicola,et al.  Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro: effects of combination with colony-stimulating factors. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[38]  M. Moore.  Review: Stratton Lecture 1990. Clinical implications of positive and negative hematopoietic stem cell regulators. , 1991, Blood.

[39]  D. Pardoll,et al.  A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations , 1991, Cell.

[40]  I. Bernstein,et al.  Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor. , 1991, Blood.

[41]  K. Zsebo,et al.  Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages. , 1991, Experimental hematology.

[42]  C. Eaves,et al.  Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[43]  J. Ihle,et al.  Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[44]  W. Vainchenker,et al.  Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: Its relationship to type β transforming growth factor (TGF‐β) , 1988 .

[45]  J. Ihle,et al.  Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. , 1987, Proceedings of the National Academy of Sciences of the United States of America.