New relationship of E2F1 and BNIP3 with caveolin‐1 in lung cancer‐associated fibroblasts

In recent years, studies have found that E2F1, a downstream effector of caveolin‐1 (Cav‐1), participates in tumor cell metabolic reprogramming. E2F1 modulates mitochondrial fusion and mitophagy. Bioinformatic analysis has identified the E2F1‐MFN2 axis as a regulator of mitophagy. Our data establish a new novel paradigm for regulation of the tumor cell metabolic reprogramming pathway by Cav‐1 that is operationally linked and mutually dependent on the transcriptional activation of E2F1 and induces mitophagy with BNIP3 in cancer‐associated fibroblasts (CAFs).

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