Silver Dressings in Wound Healing: What Is the Evidence?

Silver has a long history of medicinal use based on its antimicrobial effects. Microbial burden can delay wound healing and makes silver an attractive local antiseptic for wounds affected this way, especially as antibiotics have limitations. Whilst there is good evidence in preclinical studies of the effects of silver on microbes and on processes that delay wound healing, evidence for the benefits of silver products on human wound healing is still far from robust. At this stage, silver products should be confined to adequately assessed wounds that are failing to heal with cheaper products, especially where microbial burden appears to be delaying healing. There are a range of silver products currently available, with differing formulations and delivery of silver, and differing product bases. Current evidence does not clearly demonstrate that one product is more effective that another, and choice of an initial product will be based on wound and patient characteristics, product availability and practitioner familiarity and preferences.

[1]  H. Ceri,et al.  The Calgary Biofilm Device: New Technology for Rapid Determination of Antibiotic Susceptibilities of Bacterial Biofilms , 1999, Journal of Clinical Microbiology.

[2]  G. Dow,et al.  Infection in chronic wounds: controversies in diagnosis and treatment. , 1999, Ostomy/wound management.

[3]  S. Modak,et al.  Sulfadiazine silver-resistant Pseudomonas in Burns. New topical agents. , 1981, Archives of surgery.

[4]  F. Gottrup,et al.  Sustained silver-releasing dressing in the treatment of diabetic foot ulcers. , 2005, British journal of nursing.

[5]  Marco Romanelli,et al.  Wound bed preparation: a systematic approach to wound management , 2003, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[6]  H J Klasen,et al.  Historical review of the use of silver in the treatment of burns. I. Early uses. , 2000, Burns : journal of the International Society for Burn Injuries.

[7]  M. Robson,et al.  Wound healing alterations caused by infection. , 1990, Clinics in plastic surgery.

[8]  C. Weller,et al.  Prevalence of mycoses in chronic lower limb wounds of people with onychomycosis and/or tinea pedis , 2005 .

[9]  K. Ballard,et al.  Avance: silver hydropolymer dressing for critically colonized wounds. , 2002, British journal of nursing.

[10]  R. Burrell,et al.  Wound management in an era of increasing bacterial antibiotic resistance: a role for topical silver treatment. , 1998, American journal of infection control.

[11]  A. Buret,et al.  Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing , 2002, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[12]  J. S. Soldevilla Agreda,et al.  Effects of an activated charcoal silver dressing on chronic wounds with no clinical signs of infection. , 2004, Journal of wound care.

[13]  P. Bowler,et al.  Controlling wound bioburden with a novel silver‐containing Hydrofiber® dressing , 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[14]  P. Jumaa Hand hygiene: simple and complex. , 2005, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[15]  A. Lansdown,et al.  Contreet Foam and Contreet Hydrocolloid: an insight into two new silver-containing dressings. , 2003, Journal of wound care.

[16]  K. Harding,et al.  Bacteria and wound healing , 2004, Current opinion in infectious diseases.

[17]  S. Thomas,et al.  An in vitro analysis of the antimicrobial properties of 10 silver-containing dressings. , 2003, Journal of wound care.

[18]  S. Thomas,et al.  A comparison of the antimicrobial effects of four silver-containing dressings on three organisms. , 2003, Journal of wound care.

[19]  A. Lansdown A review of the use of silver in wound care: facts and fallacies. , 2004, British journal of nursing.

[20]  B. Doebbeling,et al.  The validity of the clinical signs and symptoms used to identify localized chronic wound infection , 2001, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[21]  R. Tarnuzzer,et al.  Biochemical analysis of acute and chronic wound environments , 1996, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[22]  K. Andersen,et al.  Clinical performance of a new silver dressing, Contreet Foam, for chronic exuding venous leg ulcers. , 2003, Journal of wound care.

[23]  E. Hahn,et al.  Influence of Bacterial Lipopolysaccharide on Healing of Chronic Experimental Ulcer in Rat , 2001, Scandinavian journal of gastroenterology.

[24]  H. Mousa,et al.  Aerobic, anaerobic and fungal burn wound infections. , 1997, The Journal of hospital infection.

[25]  S. Modak,et al.  Binding of silver sulfadiazine to the cellular components of Pseudomonas aeruginosa. , 1973, Biochemical pharmacology.

[26]  M. Walker,et al.  Microbicidal properties of a silver-containing hydrofiber dressing against a variety of burn wound pathogens. , 2004, The Journal of burn care & rehabilitation.

[27]  C. Power,et al.  Bacterial wall products induce downregulation of vascular endothelial growth factor receptors on endothelial cells via a CD14-dependent mechanism: implications for surgical wound healing. , 2001, The Journal of surgical research.

[28]  M. Laato,et al.  Inflammatory reaction and blood flow in experimental wounds inoculated with Staphylococcus aureus. , 1988, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.

[29]  K. Foster,et al.  Aquacel Ag in the management of partial-thickness burns: results of a clinical trial. , 2004, The Journal of burn care & rehabilitation.

[30]  A. Singer,et al.  Persistent wound infection delays epidermal maturation and increases scarring in thermal burns , 2002, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[31]  L. Ovington Bacterial toxins and wound healing. , 2003, Ostomy/wound management.

[32]  S. Bohbot,et al.  A silver sulphadiazine-impregnated lipidocolloid wound dressing to treat second-degree burns. , 2004, Journal of wound care.

[33]  R. Burrell A scientific perspective on the use of topical silver preparations. , 2003, Ostomy/Wound Management.

[34]  D. Keast,et al.  Preparing the wound bed--debridement, bacterial balance, and moisture balance. , 2000, Ostomy/wound management.

[35]  R. Sibbald,et al.  Screening evaluation of an ionized nanocrystalline silver dressing in chronic wound care. , 2001, Ostomy/wound management.

[36]  C. L. Fox Silver sulfadiazine--a new topical therapy for Pseudomonas in burns. Therapy of Pseudomonas infection in burns. , 1968, Archives of surgery.