Infectious Disease Informatics: Syndromic Surveillance for Public Health and BioDefense

While all the international infectious disease surveillance systems share similar objectives, each system site varies in its system architecture, its information processing management techniques, its algorithms for detection, and each focus on different diseases. INFECTIOUS DISEASE INFORMATICS: Syndromic Surveillance for Public Health and Bio-Defense corrects these problems. The book will analyze and evaluate the outbreak modeling and detection capabilities of the existing surveillance systems from a systematic framework. Specifically, the book will meet the following critical needs in detecting infectious diseases: It will provide an integrated, synthesized, and interdisciplinary analysis of infectious surveillance techniques. It will include statistical modeling techniques, but go beyond statistical modeling to include information systems design, data standards, computational aspects of bio-surveillance, information visualization, and system evaluation. It will emphasize the practical importance of the area and integrate the material from Public Health, Computer Science, Information Systems, Software Engineering, Public Administration Policy, Geographical Information Systems, etc. into a unified state-of-the-art treatment of syndromic surveillance systems. By its very nature, infectious disease surveillance is a dynamic, fast-moving field. Therefore the book will provide policy makers and public health practitioners with the most recent research findings, methodologies, and implementation issues from case studies of concrete application scenarios.

[1]  F. Carrat,et al.  Monitoring epidemiologic surveillance data using hidden Markov models. , 1999, Statistics in medicine.

[2]  Colleen A Bradley,et al.  BioSense: implementation of a National Early Event Detection and Situational Awareness System. , 2005, MMWR supplements.

[3]  J. Hadler,et al.  Hospital admissions syndromic surveillance--Connecticut, September 200-November 2003. , 2004, MMWR supplements.

[4]  K. Mandl,et al.  Connecting health departments and providers: syndromic surveillance's last mile. , 2005, MMWR supplements.

[5]  Robert T. Olszewski Bayesian Classification of Triage Diagnoses for the Early Detection of Epidemics , 2003, FLAIRS.

[6]  David M. Hartley,et al.  Syndromic Surveillance and Bioterrorism-related Epidemics , 2003, Emerging infectious diseases.

[7]  K Kleinman,et al.  Ambulatory-care diagnoses as potential indicators of outbreaks of gastrointestinal illness--Minnesota. , 2005, MMWR supplements.

[8]  M. Kulldor,et al.  Prospective time-periodic geographical disease surveillance using a scan statistic , 2001 .

[9]  Hsinchun Chen,et al.  Meeting medical terminology needs-the ontology-enhanced Medical Concept Mapper , 2001, IEEE Transactions on Information Technology in Biomedicine.

[10]  M. Kulldorff Spatial Scan Statistics: Models, Calculations, and Applications , 1999 .

[11]  Bruce J. West Auto regressive Integrated Moving Average (ARIMA) , 1999 .

[12]  Paola Sebastiani,et al.  Automated Detection of Influenza Epidemics with Hidden Markov Models , 2003, IDA.

[13]  Joseph S. Lombardo,et al.  A systems overview of the Electronic Surveillance System for the Early Notification of Community-Based Epidemics (ESSENCE II) , 2003, Journal of Urban Health.

[14]  David L. Buckeridge,et al.  Knowledge-based bioterrorism surveillance , 2002, AMIA.

[15]  J. Pavlin Investigation of disease outbreaks detected by “syndromic” surveillance systems , 2003, Journal of Urban Health.

[16]  Elena N Naumova,et al.  INFERNO: a system for early outbreak detection and signature forecasting. , 2005, MMWR supplements.

[17]  Stephanie W. Haas,et al.  Evaluation of emergency medical text processor, a system for cleaning chief complaint text data. , 2004, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[18]  Galit Shmueli,et al.  Early statistical detection of anthrax outbreaks by tracking over-the-counter medication sales , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Andrew W. Moore,et al.  Algorithms for rapid outbreak detection: a research synthesis , 2005, J. Biomed. Informatics.

[20]  G. Wallstrom,et al.  High-fidelity injection detectability experiments: a tool for evaluating syndromic surveillance systems. , 2005, MMWR supplements.

[21]  Gunther Eysenbach,et al.  Infodemiology: Tracking Flu-Related Searches on the Web for Syndromic Surveillance , 2006, AMIA.

[22]  Toshiro Tango,et al.  International Journal of Health Geographics a Flexibly Shaped Space-time Scan Statistic for Disease Outbreak Detection and Monitoring , 2022 .

[23]  Debbie A. Travers,et al.  Timeliness of Emergency Department Diagnoses for Syndromic Surveillance , 2006, AMIA.

[24]  R. Serfling Methods for current statistical analysis of excess pneumonia-influenza deaths. , 1963, Public health reports.

[25]  William T. Hole,et al.  Who is Using the UMLS and How - Insights from the UMLS User Annual Reports , 2006, AMIA.

[26]  Jianping Guo,et al.  The application of space/time analysis tools of GIS in spatial epidemiology: a case study of hepatitis B in China using GIS , 2005, Proceedings. 2005 IEEE International Geoscience and Remote Sensing Symposium, 2005. IGARSS '05..

[27]  Bert Veenendaal,et al.  Applying cusum-based methods for the detection of outbreaks of Ross River virus disease in Western Australia , 2008, BMC Medical Informatics Decis. Mak..

[28]  Alan M. MacEachren,et al.  Visualizing Georeferenced Data: Representing Reliability of Health Statistics , 1998 .

[29]  F. Mostashari,et al.  Enhanced drop-in syndromic surveillance in New York City following September 11, 2001 , 2003, Journal of Urban Health.

[30]  William B. Lober,et al.  Review Paper: Implementing Syndromic Surveillance: A Practical Guide Informed by the Early Experience , 2003, J. Am. Medical Informatics Assoc..

[31]  Paul Jen-Hwa Hu,et al.  Evaluating an Infectious Disease Information Sharing and Analysis System , 2005, ISI.

[32]  D. Buckeridge,et al.  Systematic Review: Surveillance Systems for Early Detection of Bioterrorism-Related Diseases , 2004, Annals of Internal Medicine.

[33]  Charles N Mead,et al.  The architecture of sharing. An HL7 Version 3 framework offers semantically interoperable healthcare information. , 2005, Healthcare informatics : the business magazine for information and communication systems.

[34]  David Madigan,et al.  Bayesian Data Mining for Health Surveillance , 2005 .

[35]  A. B. Yeh,et al.  A likelihood-ratio-based EWMA control chart for monitoring variability of multivariate normal processes , 2004 .

[36]  P A Rogerson,et al.  Surveillance systems for monitoring the development of spatial patterns. , 1997, Statistics in medicine.

[37]  Chunju Tseng,et al.  BioPortal: an integrated infectious disease information sharing and analysis environment , 2005, DG.O.

[38]  D. Siegrist,et al.  The threat of biological attack: why concern now? , 1999, Emerging infectious diseases.

[39]  Lori Hutwagner,et al.  Comparing Aberration Detection Methods with Simulated Data , 2005, Emerging infectious diseases.

[40]  J. Hughes,et al.  Disease Surveillance and the Academic, Clinical, and Public Health Communities , 2003, Emerging infectious diseases.

[41]  Garrick L. Wallstrom,et al.  Unsupervised clustering of over-the-counter healthcare products into product categories , 2007, J. Biomed. Informatics.

[42]  Lisa J. Trigg,et al.  Syndromic surveillance using automated collection of computerized discharge diagnoses , 2003, Journal of Urban Health.

[43]  Hervé Chaudet,et al.  Bmc Medical Informatics and Decision Making Value of Syndromic Surveillance within the Armed Forces for Early Warning during a Dengue Fever Outbreak in French Guiana in 2006 , 2022 .

[44]  M. Musen,et al.  Bioterrorism preparedness and response: use of information technologies and decision support systems. , 2002, Evidence report/technology assessment.

[45]  Chunju Tseng,et al.  West Nile Virus and Botulism Portal: A Case Study in Infectious Disease Informatics , 2004, ISI.

[46]  M. Kulldorff,et al.  A Tree‐Based Scan Statistic for Database Disease Surveillance , 2003, Biometrics.

[47]  P. Switzer,et al.  An evaluation model for syndromic surveillance: assessing the performance of a temporal algorithm. , 2005, MMWR supplements.

[48]  P. Quénel,et al.  Sensitivity, specificity and predictive values of health service based indicators for the surveillance of influenza A epidemics. , 1994, International journal of epidemiology.

[49]  Hsinchun Chen,et al.  Syndromic surveillance systems , 2008, Annu. Rev. Inf. Sci. Technol..

[50]  K. Mandl,et al.  Implementation of laboratory order data in BioSense Early Event Detection and Situation Awareness System. , 2005, MMWR supplements.

[51]  L. Goss,et al.  A day at the races: Communitywide syndromic surveillance during the 2002 Kentucky Deby Festival , 2003, Journal of Urban Health.

[52]  Chwan-Chuen King,et al.  Establishing a nationwide emergency department-based syndromic surveillance system for better public health responses in Taiwan , 2008, BMC public health.

[53]  K. Taniguchi,et al.  Web-based Japanese syndromic surveillance for FIFA World Cup 2002 , 2003, Journal of Urban Health.

[54]  H. Burkom Biosurveillance applying scan statistics with multiple, disparate data sources , 2003, Journal of Urban Health.

[55]  Chunju Tseng,et al.  Incorporating Geographical Contacts into Social Network Analysis for Contact Tracing in Epidemiology: A Study on Taiwan SARS Data , 2007, BioSurveillance.

[56]  Chunju Tseng,et al.  BioPortal: a case study in infectious disease informatics , 2005, Proceedings of the 5th ACM/IEEE-CS Joint Conference on Digital Libraries (JCDL '05).

[57]  Ben Y. Reis,et al.  Surveillance Sans Frontières: Internet-Based Emerging Infectious Disease Intelligence and the HealthMap Project , 2008, PLoS medicine.

[58]  J. Gibson,et al.  Health information privacy and syndromic surveillance systems. , 2004, MMWR supplements.

[59]  Yuval Shahar,et al.  Knowledge-based temporal abstraction in clinical domains , 1996, Artif. Intell. Medicine.

[60]  Andrew W. Moore,et al.  A Bayesian Spatial Scan Statistic , 2005, NIPS.

[61]  H. Kelly,et al.  An evaluation of the Australian Sentinel Practice Research Network (ASPREN) surveillance for influenza-like illness. , 2005, Communicable diseases intelligence quarterly report.

[62]  Rajshekhar Sunderraman,et al.  Health Level-7 compliant clinical patient records system , 2004, SAC '04.

[63]  Andrew W. Moore,et al.  Rule-based anomaly pattern detection for detecting disease outbreaks , 2002, AAAI/IAAI.

[64]  Tom Burr,et al.  Modeling emergency department visit patterns for infectious disease complaints: results and application to disease surveillance , 2005, BMC Medical Informatics Decis. Mak..

[65]  Chunju Tseng,et al.  Global Foot-and-Mouth Disease Surveillance Using BioPortal , 2007, BioSurveillance.

[66]  Injury and illness surveillance in hospitals and acute-care facilities after Hurricanes Katrina And Rita--New Orleans area, Louisiana, September 25-October 15, 2005. , 2006, MMWR. Morbidity and mortality weekly report.

[67]  Hsinchun Chen,et al.  Spatial-Temporal Cross-Correlation Analysis: A New Measure and a Case Study in Infectious Disease Informatics , 2006, ISI.

[68]  Andrew F. Nelson,et al.  Syndromic surveillance using minimum transfer of identifiable data: The example of the national bioterrorism syndromic surveillance demonstration program , 2003, Journal of Urban Health.

[69]  L Ma,et al.  Removing a barrier to computer-based outbreak and disease surveillance--the RODS Open Source Project. , 2004, MMWR supplements.

[70]  P. Good,et al.  Development of an Alternative Surveillance Alert Program (ASAP): Syndromic surveillance of gastrointestinal illness using pharmacy over-the-counter sales , 2003, Journal of Urban Health.

[71]  Ben Shneiderman,et al.  The eyes have it: a task by data type taxonomy for information visualizations , 1996, Proceedings 1996 IEEE Symposium on Visual Languages.

[72]  S. J. Wang,et al.  Syndromic surveillance based on the emergency department in Korea , 2003, Journal of Urban Health.

[73]  Farzad Mostashari,et al.  Monitoring the Impact of Influenza by Age: Emergency Department Fever and Respiratory Complaint Surveillance in New York City , 2007, PLoS medicine.

[74]  Christopher G Chute Editorial Comments: Biosurveillance, Classification, and Semantic Health Technologies , 2008, J. Am. Medical Informatics Assoc..

[75]  M. Oermann,et al.  [Clinical evaluation]. , 1981, Ugeskrift for laeger.

[76]  W. Chapman,et al.  Syndrome and outbreak detection using chief-complaint data--experience of the Real-Time Outbreak and Disease Surveillance project. , 2004, MMWR supplements.

[77]  Michael M. Wagner,et al.  Technical Description of RODS: A Real-time Public Health Surveillance System , 2003, Journal of the American Medical Informatics Association.

[78]  Wei Chang,et al.  A novel spatio-temporal data analysis approach based on prospective support vector clustering , 2005 .

[79]  C. Sniegoski Automated Syndromic Classifi cation of Chief Complaint Records , 2004 .

[80]  Jeff Aramini,et al.  Syndromic Surveillance of Gastrointestinal Illness Using Pharmacy Over-the-Counter Sales , 2004, Canadian journal of public health = Revue canadienne de sante publique.

[81]  Michael M. Wagner,et al.  Detection of Pediatric Respiratory and Gastrointestinal Outbreaks from Free-Text Chief Complaints , 2003, AMIA.

[82]  N. Verlander,et al.  Evaluation of syndromic surveillance based on National Health Service Direct derived data--England and Wales. , 2005, MMWR supplements.

[83]  A Nelson,et al.  National Bioterrorism Syndromic Surveillance Demonstration Program. , 2004, MMWR supplements.

[84]  Daniel B. Neill,et al.  National Retail Data Monitor for public health surveillance. , 2004, MMWR supplements.

[85]  Peter J. Haug,et al.  Rapid deployment of an electronic disease surveillance system in the state of Utah for the 2002 Olympic Winter Games , 2002, AMIA.

[86]  Debbie A. Travers,et al.  Evaluation of preprocessing techniques for chief complaint classification , 2008, J. Biomed. Informatics.

[87]  A. Flahault,et al.  A routine tool for detection and assessment of epidemics of influenza-like syndromes in France. , 1991, American journal of public health.

[88]  D. Durrheim,et al.  The public health value of emergency department syndromic surveillance following a natural disaster. , 2008, Communicable diseases intelligence quarterly report.

[89]  Daniel Zeng,et al.  Prospective spatio-temporal data analysis for security informatics , 2005, Proceedings. 2005 IEEE Intelligent Transportation Systems, 2005..

[90]  Ken P Kleinman,et al.  Assessing surveillance using sensitivity, specificity and timeliness , 2006, Statistical methods in medical research.

[91]  Ganesh S. Oak Information Visualization Introduction , 2022 .

[92]  Kenneth D. Mandl,et al.  Time series modeling for syndromic surveillance , 2003, BMC Medical Informatics Decis. Mak..

[93]  Ben Shneiderman,et al.  Designing the User Interface: Strategies for Effective Human-Computer Interaction , 1998 .

[94]  J. Pavlin,et al.  Bio-ALIRT biosurveillance detection algorithm evaluation. , 2004, MMWR supplements.

[95]  Marcello Pagano,et al.  Using temporal context to improve biosurveillance , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[96]  Camille Pelat,et al.  Online detection and quantification of epidemics , 2007, BMC Medical Informatics Decis. Mak..

[97]  D. Talan,et al.  Syndromic surveillance for bioterrorism following the attacks on the World Trade Center--New York City, 2001. , 2003, MMWR. Morbidity and mortality weekly report.

[98]  Yiliang Zhu,et al.  Initial evaluation of the early aberration reporting system--Florida. , 2005, MMWR supplements.

[99]  Howard S. Burkom,et al.  Data Classification for Selection of Temporal Alerting Methods for Biosurveillance , 2007, BioSurveillance.

[100]  Anders Skrondal,et al.  A simulation study of three methods for detecting disease clusters , 2006, International journal of health geographics.

[101]  Fred S. Roberts,et al.  Challenges for Discrete Mathematics and Theoretical Computer Science in the Defense against Bioterrorism , 2010 .

[102]  Kent L. Norman,et al.  Development of an instrument measuring user satisfaction of the human-computer interface , 1988, CHI '88.

[103]  Alyson G. Wilson,et al.  Statistical methods in counterterrorism : game theory, modeling, syndromic surveillance, and biometric authentication , 2006 .

[104]  A. Flahault,et al.  Medication Sales and Syndromic Surveillance, France , 2006, Emerging infectious diseases.

[105]  Arthur B. Yeh,et al.  A multivariate exponentially weighted moving average control chart for monitoring process variability , 2003 .

[106]  Hsinchun Chen,et al.  Chinese Chief Complaint Classification for Syndromic Surveillance , 2007, BioSurveillance.

[107]  S. Groseclose,et al.  Evaluating Public Health Surveillance , 2010 .

[108]  William B. Lober,et al.  Roundtable on bioterrorism detection: information system-based surveillance. , 2002, Journal of the American Medical Informatics Association : JAMIA.

[109]  Weng-Keen Wong,et al.  Bayesian Biosurveillance of Disease Outbreaks , 2004, UAI.

[110]  F. Boscoe,et al.  Visualization of the spatial scan statistic using nested circles. , 2003, Health & place.

[111]  Kenneth D. Mandl,et al.  HealthMap: Global Infectious Disease Monitoring through Automated Classification and Visualization of Internet Media Reports , 2008, Journal of the American Medical Informatics Association.

[112]  Michael M. Wagner,et al.  Experience with Message Format and Code Set Standards for Early Warning Public Health Surveillance Systems , 2002, AMIA.

[113]  Peter A. Rogerson,et al.  Spatial Surveillance and Cumulative Sum Methods , 2005 .

[114]  M. Shigematsu,et al.  Experimental surveillance using data on sales of over-the-counter medications--Japan, November 2003-April 2004. , 2005, MMWR supplements.

[115]  J. Hadler,et al.  Guidelines for constructing a statewide hospital syndromic surveillance network. , 2005, MMWR supplements.

[116]  Michael M. Wagner,et al.  Value of ICD-9-Coded Chief Complaints for Detection of Epidemics , 2002, J. Am. Medical Informatics Assoc..

[117]  David Bock,et al.  A review and discussion of prospective statistical surveillance in public health , 2003 .

[118]  C. Rodriguez,et al.  New York City syndromic surveillance systems. , 2004, MMWR supplements.

[119]  R. German,et al.  Sensitivity and Predictive Value Positive Measurements for Public Health Surveillance Systems , 2000, Epidemiology.

[120]  F. Mostashari,et al.  Syndromic surveillance: A local perspective , 2003, Journal of Urban Health.

[121]  S. Thacker,et al.  HIPAA privacy rule and public health. Guidance from CDC and the U.S. Department of Health and Human Services. , 2003, MMWR supplements.

[122]  Kathy J Hurt-Mullen,et al.  Syndromic surveillance on the epidemiologist's desktop: making sense of much data. , 2005, MMWR supplements.

[123]  Peter A. Bath,et al.  Data mining in health and medical information , 2005, Annu. Rev. Inf. Sci. Technol..

[124]  Jeffrey S. Duchin,et al.  A simulation study comparing aberration detection algorithms for syndromic surveillance , 2007, BMC Medical Informatics Decis. Mak..

[125]  V. Watzlaf,et al.  The effectiveness of ICD-10-CM in capturing public health diseases. , 2007, Perspectives in health information management.

[126]  R Platt,et al.  Simulation for assessing statistical methods of biologic terrorism surveillance. , 2005, MMWR supplements.

[127]  J. Marc Overhage,et al.  Research Paper: Detection of Pediatric Respiratory and Diarrheal Outbreaks from Sales of Over-the-counter Electrolyte Products , 2003, J. Am. Medical Informatics Assoc..

[128]  H. Burkom,et al.  Syndromic Surveillance: Adapting Innovations to Developing Settings , 2008, PLoS medicine.

[129]  Wendy W. Chapman,et al.  Accuracy of three classifiers of acute gastrointestinal syndrome for syndromic surveillance , 2002, AMIA.

[130]  G W Beeler,et al.  HL7 version 3--an object-oriented methodology for collaborative standards development. , 1998, International journal of medical informatics.

[131]  Andrew D. Boyd,et al.  Representing Natural-Language Case Report Form Terminology Using Health Level 7 Common Document Architecture, LOINC, and SNOMED-CT: Lessons Learned , 2006, AMIA.

[132]  L. Hutwagner,et al.  The bioterrorism preparedness and response Early Aberration Reporting System (EARS) , 2003, Journal of Urban Health.

[133]  Hsinchun Chen,et al.  A Review of Public Health Syndromic Surveillance Systems , 2006, ISI.

[134]  J. Casani,et al.  The National Capitol Region’s Emergency Department Syndromic Surveillance System: 
Do Chief Complaint and Discharge Diagnosis Yield Different Results? , 2003, Emerging infectious diseases.

[135]  R. Platt,et al.  Using automated medical records for rapid identification of illness syndromes (syndromic surveillance): the example of lower respiratory infection , 2001, BMC public health.

[136]  Jun Zhang,et al.  Detection of Outbreaks from Time Series Data Using Wavelet Transform , 2003, AMIA.

[137]  Gail Graham,et al.  A Simple Strategy for Implementing Standard Reference Terminologies in a Distributed Healthcare Delivery System with Minimal Impact to Existing Applications , 2006, AMIA.

[138]  Hsinchun Chen,et al.  BioPortal Infectious Disease Informatics research: disease surveillance and situational awareness , 2008, DG.O.

[139]  Daniel Zeng,et al.  Syndromic surveillance systems , 2008, Annual Review of Information Science and Technology.

[140]  Peter J. Haug,et al.  Classifying free-text triage chief complaints into syndromic categories with natural language processing , 2005, Artif. Intell. Medicine.

[141]  Allyson M. Abrams,et al.  A model-adjusted space–time scan statistic with an application to syndromic surveillance , 2005, Epidemiology and Infection.

[142]  Zhen Liu,et al.  The RODS Open Source Project: Removing a Barrier to Syndromic Surveillance , 2004, MedInfo.

[143]  Andrew W. Moore,et al.  Cached Sufficient Statistics for Efficient Machine Learning with Large Datasets , 1998, J. Artif. Intell. Res..

[144]  Andrew W. Moore,et al.  Data, network, and application: technical description of the Utah RODS Winter Olympic Biosurveillance System , 2002, AMIA.

[145]  Bert Veenendaal,et al.  Using GIS to create synthetic disease outbreaks , 2007, BMC Medical Informatics Decis. Mak..

[146]  Jeff Kabachinski,et al.  What is Health Level 7? , 2006, Biomedical instrumentation & technology.

[147]  A S Neubauer,et al.  The EWMA control chart: properties and comparison with other quality-control procedures by computer simulation. , 1997, Clinical chemistry.

[148]  Gregory F. Cooper,et al.  Estimating the joint disease outbreak-detection time when an automated biosurveillance system is augmenting traditional clinical case finding , 2008, J. Biomed. Informatics.

[149]  I. Yu,et al.  Predicting Super Spreading Events during the 2003 Severe Acute Respiratory Syndrome Epidemics in Hong Kong and Singapore , 2004, American journal of epidemiology.

[150]  Melanie C Besculides Richard Heffernan Farzad Mostashari J Weissman Evaluation of School Absenteeism Data for Early Outbreak Detection New York City 20012002 , 2004 .

[151]  Surveillance in hurricane evacuation centers--Louisiana, September-October 2005. , 2006, MMWR. Morbidity and mortality weekly report.

[152]  Andrew B. Lawson,et al.  Spatial and syndromic surveillance for public health , 2005 .

[153]  S. Magruder Evaluation of Over-the-Counter Pharmaceutical Sales As a Possible Early Warning Indicator of Human Disease , 2003 .

[154]  Dean F. Sittig,et al.  The emerging science of very early detection of disease outbreaks. , 2001, Journal of public health management and practice : JPHMP.

[155]  D. Fridsma,et al.  BioWar : Scalable Multi-Agent Social and Epidemiological Simulation of Bioterrorism Events , 2003 .

[156]  David L. Buckeridge,et al.  Ontology-centered syndromic surveillance for bioterrorism , 2005, IEEE Intelligent Systems.

[157]  David L. Buckeridge,et al.  An Analytic Framework for Space-Time Aberrancy Detection in Public Health Surveillance Data , 2003, AMIA.

[158]  Hsinchun Chen,et al.  Ontology-enhanced automatic chief complaint classification for syndromic surveillance , 2008, J. Biomed. Informatics.

[159]  William B. Lober,et al.  Syndromic Surveillance for Bioterrorism Using Computerized Discharge Diagnosis Databases , 2001, AMIA.

[160]  A. Moore,et al.  Wsare: What’s strange about recent events? , 2003, Journal of Urban Health.

[161]  Kenneth D. Mandl,et al.  A software tool for creating simulated outbreaks to benchmark surveillance systems , 2005, BMC Medical Informatics Decis. Mak..

[162]  A. Reingold,et al.  If syndromic surveillance is the answer, what is the question? , 2003, Biosecurity and bioterrorism : biodefense strategy, practice, and science.

[163]  Richard Platt,et al.  Use of Automated Ambulatory-Care Encounter Records for Detection of Acute Illness Clusters, Including Potential Bioterrorism Events , 2002, Emerging infectious diseases.

[164]  M. Kulldorff,et al.  Syndromic surveillance in public health practice, New York City. , 2004, Emerging infectious diseases.

[165]  Andrew W. Moore,et al.  What's Strange About Recent Events (WSARE): An Algorithm for the Early Detection of Disease Outbreaks , 2005, J. Mach. Learn. Res..

[166]  Stephanie D. Miller,et al.  New Hampshire emergency department syndromic surveillance system , 2003, Journal of Urban Health.

[167]  L C Hutwagner,et al.  A simulation model for assessing aberration detection methods used in public health surveillance for systems with limited baselines , 2005, Statistics in medicine.

[168]  I. Kohane,et al.  An Epidemiological Network Model for Disease Outbreak Detection , 2007, PLoS medicine.

[169]  Torsten Staab,et al.  The Rapid Syndrome Validation Project (RSVP) , 2001, AMIA.

[170]  Ben Y. Reis,et al.  Syndromic surveillance: the effects of syndrome grouping on model accuracy and outbreak detection. , 2004, Annals of emergency medicine.

[171]  Todd A. Ritter LEADERS: Lightweight Epidemiology Advanced Detection and Emergency Response System , 2002, SPIE Defense + Commercial Sensing.

[172]  Eric C. Pan,et al.  The value of health care information exchange and interoperability. , 2005, Health affairs.

[173]  H. Burkom,et al.  Role of data aggregation in biosurveillance detection strategies with applications from ESSENCE. , 2004, MMWR supplements.

[174]  Daniel Zeng,et al.  A comparative study of spatio-temporal hotspot analysis techniques in security informatics , 2004, Proceedings. The 7th International IEEE Conference on Intelligent Transportation Systems (IEEE Cat. No.04TH8749).

[175]  H Rolka,et al.  Deciphering data anomalies in BioSense. , 2005, MMWR supplements.