Dengue Myositis and Review of Literature

Dengue is an acute mosquito-borne infection caused by dengue viruses from the genus flavivirus. Although viral myositis is common, myositis caused by dengue virus is not commonly reported. We present a case of an 18 year old female with serologically confirmed dengue fever presenting with severe myalgia and lower limb weakness. Twenty fold elevation of serum creatinine kinase level was noted. She was conservatively managed and made an uneventful recovery. Myositis with dengue virus may be under-recognized and under reported. We suggest that patients with dengue fever presenting with severe myalgia should have serum creatinine kinase levels checked and urinalysis for myoglobinuria for early detection and prevention of rhabdomyolysis.

[1]  S. Lanka,et al.  Current Management of Dengue in Adults: a Review , 2020 .

[2]  R. Garg,et al.  Acute dengue virus myositis: A report of seven patients of varying clinical severity including two cases with severe fulminant myositis , 2011, Journal of the Neurological Sciences.

[3]  S. Acharya,et al.  Acute dengue myositis with rhabdomyolysis and acute renal failure , 2010, Annals of Indian Academy of Neurology.

[4]  A. Rothman,et al.  Efficient dengue virus (DENV) infection of human muscle satellite cells upregulates type I interferon response genes and differentially modulates MHC I expression on bystander and DENV-infected cells. , 2008, The Journal of general virology.

[5]  J. Finsterer,et al.  Severe, persisting, steroid-responsive Dengue myositis. , 2006, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[6]  A. Mahadevan,et al.  1460 Acute pure motor quadriplegia: is it dengue myositis? , 2005, Journal of the Neurological Sciences.

[7]  Joshua S. Davis,et al.  Rhabdomyolysis associated with dengue virus infection. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[8]  D. Vaughn,et al.  Cytokine gene expression and protein production in peripheral blood mononuclear cells of children with acute dengue virus infections , 2002, Journal of medical virology.

[9]  A. Adikaram,et al.  Myoglobinuric acute renal failure following dengue viral infection. , 2000, The Ceylon medical journal.

[10]  A. Gabbai,et al.  Dengue. Muscle biopsy findings in 15 patients. , 1993, Arquivos de neuro-psiquiatria.