Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice

[1]  F. Martinez,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. , 2007, American journal of respiratory and critical care medicine.

[2]  M. Gladwin,et al.  Perivascular T-cell infiltration leads to sustained pulmonary artery remodeling after endothelial cell damage. , 2011, American journal of respiratory cell and molecular biology.

[3]  P. Palange,et al.  Circulating endothelial progenitor cells and chronic pulmonary diseases , 2011, European Respiratory Journal.

[4]  D. Sin,et al.  Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling. , 2011, American journal of respiratory and critical care medicine.

[5]  L. Ellisen.  Smoking and emphysema: the stress connection , 2010, Nature Medicine.

[6]  M. Borchers,et al.  Chronic cigarette smoke exposure generates pathogenic T cells capable of driving COPD-like disease in Rag2-/- mice. , 2010, American journal of respiratory and critical care medicine.

[7]  A. Chaouat,et al.  Pulmonary hypertension in COPD: epidemiology, significance, and management: pulmonary vascular disease: the global perspective. , 2010, Chest.

[8]  S. Biswal,et al.  Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke – induced pulmonary injury and emphysema , 2010, Nature Medicine.

[9]  M. Rock,et al.  T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension. , 2010, Respiratory medicine.

[10]  D. Mannino,et al.  Burden and pathogenesis of chronic obstructive pulmonary disease. , 2009, Proceedings of the American Thoracic Society.

[11]  V. Peinado,et al.  Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig , 2009, Respiratory research.

[12]  Paul L Huang,et al.  Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. , 2009, The American journal of pathology.

[13]  W. Seeger,et al.  Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia , 2009, European Respiratory Journal.

[14]  P. Barnes,et al.  Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients. , 2009, Chest.

[15]  V. Peinado,et al.  Pulmonary vascular involvement in COPD. , 2008, Chest.

[16]  I. Adcock,et al.  Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction , 2008, European Respiratory Journal.

[17]  P. Black,et al.  Changes in elastic fibres in the small airways and alveoli in COPD , 2008, European Respiratory Journal.

[18]  M. Cosio,et al.  Mechanisms of cigarette smoke-induced COPD: insights from animal models. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[19]  S. Erzurum,et al.  Copyright © American Society for Investigative Pathology DOI: 10.2353/ajpath.2008.070705 Cardiovascular, Pulmonary and Renal Pathology Circulating Angiogenic Precursors in Idiopathic Pulmonary Arterial Hypertension , 2022 .

[20]  Laimute Taraseviciene-Stewart,et al.  Molecular pathogenesis of emphysema. , 2008, The Journal of clinical investigation.

[21]  F. Sciurba,et al.  Autoantibodies in patients with chronic obstructive pulmonary disease. , 2008, American journal of respiratory and critical care medicine.

[22]  A. Woodcock,et al.  Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. , 2007, American journal of respiratory and critical care medicine.

[23]  P. Tripathi.  Nitric oxide and immune response. , 2007, Indian journal of biochemistry & biophysics.

[24]  F. Liew,et al.  Nitric oxide induces CD4+CD25+ Foxp3− regulatory T cells from CD4+CD25− T cells via p53, IL-2, and OX40 , 2007, Proceedings of the National Academy of Sciences.

[25]  W. Seeger,et al.  Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature , 2007, Circulation research.

[26]  Csaba Szabó,et al.  Peroxynitrite: biochemistry, pathophysiology and development of therapeutics , 2007, Nature Reviews Drug Discovery.

[27]  Toshinori Yoshida,et al.  Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. , 2007, Physiological reviews.

[28]  M. Gladwin,et al.  Measurement of circulating nitrite and S-nitrosothiols by reductive chemiluminescence. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[29]  T. Gudermann,et al.  Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange , 2006, Proceedings of the National Academy of Sciences.

[30]  B. Y. Chin,et al.  Carbon monoxide reverses established pulmonary hypertension , 2006, The Journal of experimental medicine.

[31]  N. Voelkel,et al.  Vascular endothelial growth factor in the lung. , 2006, American journal of physiology. Lung cellular and molecular physiology.

[32]  A. Churg,et al.  Vasoactive mediators and pulmonary hypertension after cigarette smoke exposure in the guinea pig. , 2006, Journal of applied physiology.

[33]  W. Seeger,et al.  Activation of Soluble Guanylate Cyclase Reverses Experimental Pulmonary Hypertension and Vascular Remodeling , 2006, Circulation.

[34]  D. Gemsa,et al.  Phenotypical and functional characterization of alveolar macrophage subpopulations in the lungs of NO2-exposed rats , 2006, Respiratory research.

[35]  C. Lenfant,et al.  Global Initiative for chronic obstructive lung disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease , 2006 .

[36]  W. Seeger,et al.  Reversal of experimental pulmonary hypertension by PDGF inhibition. , 2005, The Journal of clinical investigation.

[37]  N. Siafakas,et al.  Nitrosative stress, heme oxygenase-1 expression and airway inflammation during severe exacerbations of COPD. , 2005, Chest.

[38]  D. Carey,et al.  Rapamycin suppresses experimental aortic aneurysm growth. , 2004, Journal of vascular surgery.

[39]  Gert Folkerts,et al.  Nitric Oxide in Health and Disease of the Respiratory System , 2022 .

[40]  W. Mitzner,et al.  The effect of neonatal hyperoxia on the lung of p21Waf1/Cip1/Sdi1-deficient mice. , 2004, American journal of respiratory cell and molecular biology.

[41]  Matthias Ochs,et al.  The number of alveoli in the human lung. , 2004, American journal of respiratory and critical care medicine.

[42]  S. Corey,et al.  Peroxynitrite inhibits enterocyte proliferation and modulates Src kinase activity in vitro. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[43]  W. Seeger,et al.  Circulating Vascular Progenitor Cells Do Not Contribute to Compensatory Lung Growth , 2003, Circulation research.

[44]  D. Harrison,et al.  Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols , 2003, Journal of Biological Chemistry.

[45]  X. Busquets,et al.  Systemic effects of chronic obstructive pulmonary disease , 2003, European Respiratory Journal.

[46]  W. Bailey,et al.  Editorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution , 2023, Medical science monitor : international medical journal of experimental and clinical research.

[47]  Jorge D. Erusalimsky,et al.  Does nitric oxide modulate mitochondrial energy generation and apoptosis? , 2002, Nature Reviews Molecular Cell Biology.

[48]  张锺儒,et al.  对急性哮喘加剧的成年患者两种不同教育干预的评价[英]／Co^^té J…∥Am J Respir Crit Care Med , 2002 .

[49]  W. Seeger,et al.  cDNA array hybridization after laser-assisted microdissection from nonneoplastic tissue. , 2002, The American journal of pathology.

[50]  T. Mak,et al.  Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3). , 2001, The Journal of clinical investigation.

[51]  S. Uhlig,et al.  Mechanisms of endotoxin-induced airway and pulmonary vascular hyperreactivity in mice. , 2000, American journal of respiratory and critical care medicine.

[52]  D. Carey,et al.  The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms. , 1999, Journal of vascular surgery.

[53]  D. Wink,et al.  Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide. , 1998, Free radical biology & medicine.

[54]  Alan D. Lopez,et al.  Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study , 1997, The Lancet.

[55]  B. Marshall,et al.  Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction. , 1996, American journal of respiratory cell and molecular biology.

[56]  A. Brody,et al.  Isolation and primary culture of murine alveolar type II cells. , 1996, American journal of respiratory cell and molecular biology.

[57]  C. Bogdan,et al.  L-N6-(1-iminoethyl)-lysine potently inhibits inducible nitric oxide synthase and is superior to NG-monomethyl-arginine in vitro and in vivo. , 1995, European journal of pharmacology.

[58]  M. Currie,et al.  L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. , 1994, Journal of medicinal chemistry.

[59]  A. Churg,et al.  Effect of long-term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pig. , 1991, Experimental lung research.

[60]  A. Churg,et al.  Cigarette smoke causes physiologic and morphologic changes of emphysema in the guinea pig. , 1990, The American review of respiratory disease.

[61]  O. Miettinen,et al.  Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery. , 1981, The American journal of physiology.