Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells.

[1]  N. Chang TGF-β-Induced Matrix Proteins Inhibit p42/44 MAPK and JNK Activation and Suppress TNF-Mediated IκBα Degradation and NF-κB Nuclear Translocation in L929 Fibroblasts , 2000 .

[2]  J. Maier,et al.  Transforming Growth Factor β2 inhibition of Hepatocyte Growth Factor-induced endothelial proliferation and migration , 2000, Oncogene.

[3]  Daniel Paris,et al.  Ligation of Microglial CD40 Results in p44/42 Mitogen-Activated Protein Kinase-Dependent TNF-α Production That Is Opposed by TGF-β1 and IL-10 , 1999, The Journal of Immunology.

[4]  S. Goff,et al.  A thrombopoietin receptor mutant deficient in Jak-STAT activation mediates proliferation but not differentiation in UT-7 cells. , 1999, Blood.

[5]  H. Kuroda,et al.  Transforming Growth Factor-β1 (TGF-β1) Induces Thrombopoietin From Bone Marrow Stromal Cells, Which Stimulates the Expression of TGF-β Receptor on Megakaryocytes and, in Turn, Renders Them Susceptible to Suppression by TGF-β Itself With High Specificity , 1999 .

[6]  H. Papadaki,et al.  Low frequency of myeloid progenitor cells in chronic idiopathic neutropenia of adults may be related to increased production of TGF‐β1 by bone marrow stromal cells , 1999, European journal of haematology.

[7]  K. Kaushansky,et al.  Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis. , 1999, Blood.

[8]  Kindred A. Ritchie,et al.  Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[9]  R. Jove,et al.  Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines. , 1999, Blood.

[10]  K. Kaushansky,et al.  Thrombopoietin signal transduction: studies from cell lines and primary cells. , 1999, Methods.

[11]  W. Hofmann,et al.  Characterization of defective megakaryocytic development in patients with myelodysplastic syndromes. , 1999, Experimental hematology.

[12]  P. Secchiero,et al.  The induction of megakaryocyte differentiation is accompanied by selective Ser133 phosphorylation of the transcription factor CREB in both HEL cell line and primary CD34+ cells. , 1998, Blood.

[13]  D. J. Van Den Berg,et al.  The Smad5 Gene Is Involved in the Intracellular Signaling Pathways That Mediate the Inhibitory Effects of Transforming Growth Factor-β on Human Hematopoiesis , 1998 .

[14]  S. Goff,et al.  The Thrombopoietin Receptor Can Mediate Proliferation without Activation of the Jak-STAT Pathway , 1997, The Journal of experimental medicine.

[15]  Kohei Miyazono,et al.  TGF-β signalling from cell membrane to nucleus through SMAD proteins , 1997, Nature.

[16]  H. Miyazaki,et al.  Thrombopoietin alone stimulates the early proliferation and survival of human erythroid, myeloid and multipotential progenitors in serum‐free culture , 1997, British journal of haematology.

[17]  S. Jacobsen,et al.  Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+ CD38-) human bone marrow progenitor cells: distinct and key interactions with the ligands for c-kit and flt3, and inhibitory effects of TGF-beta and TNF-alpha. , 1997, Journal of immunology.

[18]  H. Jun,et al.  Molecular role of TGF-beta, secreted from a new type of CD4+ suppressor T cell, NY4.2, in the prevention of autoimmune IDDM in NOD mice. , 1997, Journal of autoimmunity.

[19]  M. Ogawa,et al.  In vitro expansion of hematopoietic stem cells , 1997, Stem cells.

[20]  S. Jacobsen,et al.  Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3. , 1996, Blood.

[21]  Lesley J. Murray,et al.  Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin− primitive progenitor cells , 1996 .

[22]  F. Ruscetti,et al.  Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells. , 1996, Blood.

[23]  V. Broudy,et al.  The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. , 1996, Blood.

[24]  K. Kaushansky,et al.  Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. , 1996, Blood.

[25]  A. Levitzki,et al.  Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor , 1996, Nature.

[26]  H. Drexler,et al.  Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells. , 1996, Leukemia.

[27]  R. Alam,et al.  Mechanism of inhibition of eosinophil activation by transforming growth factor-beta. Inhibition of Lyn, MAP, Jak2 kinases and STAT1 nuclear factor. , 1995, Journal of immunology.

[28]  W. Vainchenker,et al.  The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. , 1995, Blood.

[29]  H. Miyazaki,et al.  Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors , 1995 .

[30]  A. Bridges,et al.  A synthetic inhibitor of the mitogen-activated protein kinase cascade. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[31]  I. Dybedal,et al.  Transforming growth factor beta (TGF-beta), a potent inhibitor of erythropoiesis: neutralizing TGF-beta antibodies show erythropoietin as a potent stimulator of murine burst-forming unit erythroid colony formation in the absence of a burst-promoting activity. , 1995, Blood.

[32]  R. Salgia,et al.  The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases. , 1995, Experimental hematology.

[33]  K. Kaushansky Thrombopoietin the primary regulator of platelet production. , 1995, Trends in endocrinology and metabolism: TEM.

[34]  B. Druker,et al.  Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets , 1995 .

[35]  D. Bonnet,et al.  Comparison of the inhibitory effect of AcSDKP, TNF-alpha, TGF-beta, and MIP-1 alpha on marrow-purified CD34+ progenitors. , 1995, Experimental hematology.

[36]  A. Ganser,et al.  In vitro culture of common acute lymphoblastic leukemia blasts: effects of interleukin-3, interleukin-7, and accessory cells. , 1992, Blood.

[37]  T. Papayannopoulou,et al.  HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression. , 1982, Science.

[38]  J. Massagué TGF-beta signal transduction. , 1998, Annual review of biochemistry.

[39]  H. Miyazaki,et al.  Thrombopoietin promotes the survival of murine hematopoietic long-term reconstituting cells: comparison with the effects of FLT3/FLK-2 ligand and interleukin-6. , 1998, Blood.