Expression of Concern Expression of Concern on “ Ubiquinol Improves Symptoms in Children with Autism ” Clinical Study Ubiquinol Improves Symptoms in Children with Autism

Background . Autism is a spectrum of neurodevelopmental disorders with manifestation within 3 years after birth. Manifestations of autism include behavior problems (hyperactivity, toys destruction, self-harm, and agression) and sleep and eating disorders. Etiology of autism is poorly understood. Oxidative stress and antioxidants can participate in pathobiochemical mechanisms of autism. Methods .Twenty-fourchildren,aged3–6years,withautismaccordingtotheDSMIVcriteriaandusingCARSwereincluded in the study. Concentrations of CoQ 10− TOTAL , 𝛾 - and 𝛼 -tocopherol, 𝛽 -carotene, and lipid peroxidation were determined in plasma before and after three months of supportive therapy with ubiquinol at a daily dose 2×50 mg. Data on behavior of the children were collected from parents at the same time. Results . Ubiquinol supportive therapy improved symptoms in children with autism, as communication with parents (in 12 %), verbal communication (in 21 %), playing games of children (in 42 %), sleeping (in 34 %), and food rejection (in 17 %), with CoQ 10− TOTAL plasma level above 2.5 𝜇 mol / L. Conclusions . Beneficial effect of ubiquinol in children with autism has been demonstrated for the first time. We assume that plasma concentration of CoQ 10− TOTAL and lipid peroxidation could be used as relevant biomarkers of ubiquinol supportive therapy.