Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals.

[1]  J. Elmquist,et al.  Sixteen years and counting: an update on leptin in energy balance. , 2011, The Journal of clinical investigation.

[2]  J. Hall,et al.  Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality , 2011, Diabetes.

[3]  Rudolph L. Leibel,et al.  Obesity and leptin resistance: distinguishing cause from effect , 2010, Trends in Endocrinology & Metabolism.

[4]  L. Rui,et al.  Recent advances in understanding leptin signaling and leptin resistance. , 2009, American journal of physiology. Endocrinology and metabolism.

[5]  E. Palmer,et al.  Identification and importance of brown adipose tissue in adult humans. , 2009, The New England journal of medicine.

[6]  H. Katagiri,et al.  Obesity alters circadian expressions of molecular clock genes in the brainstem , 2009, Brain Research.

[7]  W. Saris,et al.  Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity , 2009, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[8]  S. Morrison,et al.  Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue. , 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

[9]  B. Cannon,et al.  UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. , 2009, Cell metabolism.

[10]  J. Samarut,et al.  Mice lacking the thyroid hormone receptor-alpha gene spend more energy in thermogenesis, burn more fat, and are less sensitive to high-fat diet-induced obesity. , 2008, Endocrinology.

[11]  S. Morrison,et al.  Central control of thermogenesis in mammals , 2008, Experimental physiology.

[12]  M. Schwartz,et al.  Immunocytochemistry and Laser Capture Microdissection for Real-time Quantitative PCR Identify Hindbrain Neurons Activated by Interaction Between Leptin and Cholecystokinin , 2008, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[13]  Hideki Katagiri,et al.  Adiposity and Cardiovascular Disorders: Disturbance of the Regulatory System Consisting of Humoral and Neuronal Signals , 2007, Circulation research.

[14]  R. Knutsen,et al.  An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension. , 2007, Cell metabolism.

[15]  Bruce M. Spiegelman,et al.  Adipocytes as regulators of energy balance and glucose homeostasis , 2006, Nature.

[16]  B. Cannon,et al.  UCP1 is essential for adaptive adrenergic nonshivering thermogenesis. , 2006, American journal of physiology. Endocrinology and metabolism.

[17]  H. Katagiri,et al.  Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity , 2006, Autonomic Neuroscience.

[18]  H. Aburatani,et al.  Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: neuronal involvement in food-intake regulation. , 2006, Cell metabolism.

[19]  L. Rossetti,et al.  Hypothalamic sensing of fatty acids , 2005, Nature Neuroscience.

[20]  T. Asano,et al.  Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. , 2005, Diabetes.

[21]  J. Agudo,et al.  Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance , 2003, Diabetologia.

[22]  M. Rossmeisl,et al.  Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. , 2003, The Journal of clinical investigation.

[23]  J. Auwerx,et al.  PPAR-γ: a thrifty transcription factor , 2003, Nuclear receptor signaling.

[24]  Mark A. Sabol,et al.  Adaptive changes in adipocyte gene expression differ in AKR/J and SWR/J mice during diet-induced obesity. , 2002, The Journal of nutrition.

[25]  R. Surwit,et al.  Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[26]  C N Boozer,et al.  Dietary obesity in nine inbred mouse strains. , 1992, The American journal of physiology.

[27]  S. Iannello,et al.  The glucose-6-phosphatase/glucokinase ratio in the liver of obese-diabetic subjects. , 1989, Biochemical Medicine and Metabolic Biology.

[28]  J. Neel.  Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? , 1962, American journal of human genetics.