Human mesenchymal stem cells differentiate into an osteogenic lineage in presence of strontium containing bioactive glass nanoparticles.

[1]  Xiaofeng Chen,et al.  Synergistic effect of strontium and silicon in strontium-substituted sub-micron bioactive glass for enhanced osteogenesis. , 2018, Materials science & engineering. C, Materials for biological applications.

[2]  M. Alini,et al.  The influence of strontium release rate from bioactive phosphate glasses on osteogenic differentiation of human mesenchymal stem cells , 2018 .

[3]  M. Kellomäki,et al.  Bioactive glass induced osteogenic differentiation of human adipose stem cells is dependent on cell attachment mechanism and mitogen-activated protein kinases. , 2018, European cells & materials.

[4]  Julian R. Jones,et al.  In vitro osteogenesis by intracellular uptake of strontium containing bioactive glass nanoparticles. , 2018, Acta biomaterialia.

[5]  J. Dixon,et al.  Osteogenic Programming of Human Mesenchymal Stem Cells with Highly Efficient Intracellular Delivery of RUNX2 , 2017, Stem cells translational medicine.

[6]  Nghia T. Vo,et al.  The effect of long-term bisphosphonate therapy on trabecular bone strength and microcrack density , 2017, Bone & joint research.

[7]  Chengtie Wu,et al.  The synergistic effects of Sr and Si bioactive ions on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration. , 2017, Acta biomaterialia.

[8]  M. Ghollasi,et al.  In vitro proliferation and differentiation of human bone marrow mesenchymal stem cells into osteoblasts on nanocomposite scaffolds based on bioactive glass (64SiO2-31CaO-5P2O5)-poly-l-lactic acid nanofibers fabricated by electrospinning method. , 2017, Materials science & engineering. C, Materials for biological applications.

[9]  J. Locs,et al.  Strontium and strontium ranelate: Historical review of some of their functions. , 2017, Materials science & engineering. C, Materials for biological applications.

[10]  D. Lorich,et al.  Atypical fracture with long-term bisphosphonate therapy is associated with altered cortical composition and reduced fracture resistance , 2017, Proceedings of the National Academy of Sciences.

[11]  Ming Yan,et al.  Nanoparticles for live cell microscopy: A surface-enhanced Raman scattering perspective , 2017, Scientific Reports.

[12]  I. Cacciotti Bivalent cationic ions doped bioactive glasses: the influence of magnesium, zinc, strontium and copper on the physical and biological properties , 2017, Journal of Materials Science.

[13]  Nghia T. Vo,et al.  Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties , 2017, Scientific Reports.

[14]  B. Lei,et al.  Intrinsic Ultrahigh Drug/miRNA Loading Capacity of Biodegradable Bioactive Glass Nanoparticles toward Highly Efficient Pharmaceutical Delivery. , 2017, ACS applied materials & interfaces.

[15]  Julian R. Jones,et al.  Influence of calcium and phosphorus release from bioactive glasses on viability and differentiation of dental pulp stem cells , 2017, Journal of Materials Science.

[16]  V. Khanduja,et al.  Bisphosphonates and atypical subtrochanteric fractures of the femur , 2017, Bone & joint research.

[17]  Julian R. Jones,et al.  Bioglass and Bioactive Glasses and Their Impact on Healthcare , 2016 .

[18]  Xiaofeng Chen,et al.  Strontium-Substituted Submicrometer Bioactive Glasses Modulate Macrophage Responses for Improved Bone Regeneration. , 2016, ACS applied materials & interfaces.

[19]  A. Grey,et al.  Ten years too long: strontium ranelate, cardiac events, and the European Medicines Agency , 2016, British Medical Journal.

[20]  J. Nedelec,et al.  Bioactive Glass Nanoparticles: From Synthesis to Materials Design for Biomedical Applications , 2016, Materials.

[21]  Julian R. Jones,et al.  Monodispersed strontium containing bioactive glass nanoparticles and MC3T3-E1 cellular response , 2016 .

[22]  D. Kaplan,et al.  Comparison of the depolarization response of human mesenchymal stem cells from different donors , 2015, Scientific Reports.

[23]  M. Kellomäki,et al.  Bioactive glass ions as strong enhancers of osteogenic differentiation in human adipose stem cells. , 2015, Acta biomaterialia.

[24]  L. Hench Opening paper 2015- Some comments on Bioglass: Four Eras of Discovery and Development , 2015 .

[25]  Peter X. Ma,et al.  Monodisperse photoluminescent and highly biocompatible bioactive glass nanoparticles for controlled drug delivery and cell imaging. , 2015, Journal of materials chemistry. B.

[26]  Molly M. Stevens,et al.  Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials , 2015, Proceedings of the National Academy of Sciences.

[27]  Ian M. Reaney,et al.  The osteogenic response of mesenchymal stromal cells to strontium‐substituted bioactive glasses , 2015, Journal of tissue engineering and regenerative medicine.

[28]  N. Voelcker,et al.  Insights into cellular uptake of nanoparticles. , 2015, Current drug delivery.

[29]  Changqing Zhang,et al.  Three-dimensional printed strontium-containing mesoporous bioactive glass scaffolds for repairing rat critical-sized calvarial defects. , 2015, Acta biomaterialia.

[30]  M. Wilkins,et al.  Identification of differentiation-stage specific markers that define the ex vivo osteoblastic phenotype. , 2014, Bone.

[31]  Guifang Gao,et al.  Bioactive nanoparticles stimulate bone tissue formation in bioprinted three-dimensional scaffold and human mesenchymal stem cells. , 2014, Biotechnology journal.

[32]  A. Grey,et al.  A comparison of adverse event and fracture efficacy data for strontium ranelate in regulatory documents and the publication record , 2014, BMJ Open.

[33]  M. Vallet‐Regí,et al.  Endocytic mechanisms of graphene oxide nanosheets in osteoblasts, hepatocytes and macrophages. , 2014, ACS applied materials & interfaces.

[34]  J. Cauley,et al.  Geographic and ethnic disparities in osteoporotic fractures , 2014, Nature Reviews Endocrinology.

[35]  Chad A. Mirkin,et al.  Intracellular Fate of Spherical Nucleic Acid Nanoparticle Conjugates , 2014, Journal of the American Chemical Society.

[36]  Ji-Ho Park,et al.  Endocytosis and exocytosis of nanoparticles in mammalian cells , 2014, International journal of nanomedicine.

[37]  E. Grove,et al.  Nationwide registry-based analysis of cardiovascular risk factors and adverse outcomes in patients treated with strontium ranelate , 2014, Osteoporosis International.

[38]  J. Borer,et al.  Ischaemic cardiac events and use of strontium ranelate in postmenopausal osteoporosis: a nested case–control study in the CPRD , 2013, Osteoporosis International.

[39]  C. Cooper,et al.  Osteoporosis in the European Union: a compendium of country-specific reports , 2013, Archives of Osteoporosis.

[40]  J. Crockett,et al.  Osteoporosis – a current view of pharmacological prevention and treatment , 2013, Drug design, development and therapy.

[41]  Warren C W Chan,et al.  The effect of nanoparticle size, shape, and surface chemistry on biological systems. , 2012, Annual review of biomedical engineering.

[42]  Yuan Yuan,et al.  Effect of size on the cellular endocytosis and controlled release of mesoporous silica nanoparticles for intracellular delivery , 2012, Biomedical microdevices.

[43]  Z. Qian,et al.  Preparation of poly(ethylene glycol)/polylactide hybrid fibrous scaffolds for bone tissue engineering , 2011, International journal of nanomedicine.

[44]  J. Reginster,et al.  Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis , 2011, Osteoporosis International.

[45]  Chung-Yuan Mou,et al.  Mesoporous silica nanoparticles as nanocarriers. , 2011, Chemical communications.

[46]  Casey K. Chan,et al.  The role of nanofibrous structure in osteogenic differentiation of human mesenchymal stem cells with serial passage. , 2011, Nanomedicine.

[47]  Jin-Woo Park,et al.  Gene expression pattern during osteogenic differentiation of human periodontal ligament cells in vitro , 2011, Journal of periodontal & implant science.

[48]  Lintao Cai,et al.  Strontium Enhances Osteogenic Differentiation of Mesenchymal Stem Cells and In Vivo Bone Formation by Activating Wnt/Catenin Signaling , 2011, Stem cells.

[49]  A. Berdal,et al.  Effects of strontium-doped bioactive glass on the differentiation of cultured osteogenic cells. , 2011, European cells & materials.

[50]  Molly M Stevens,et al.  Spherical bioactive glass particles and their interaction with human mesenchymal stem cells in vitro. , 2011, Biomaterials.

[51]  P. Marie Strontium ranelate in osteoporosis and beyond: identifying molecular targets in bone cell biology. , 2010, Molecular interventions.

[52]  Gavin Jell,et al.  The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro. , 2010, Biomaterials.

[53]  M. Keogh,et al.  A novel collagen scaffold supports human osteogenesis—applications for bone tissue engineering , 2010, Cell and Tissue Research.

[54]  Walter H. Chang,et al.  Modulation of osteogenesis in human mesenchymal stem cells by specific pulsed electromagnetic field stimulation , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[55]  M. Rybchyn,et al.  Osteoblasts play key roles in the mechanisms of action of strontium ranelate , 2009, British journal of pharmacology.

[56]  B. Steele,et al.  Association of low-energy femoral fractures with prolonged bisphosphonate use: a case control study , 2009, Osteoporosis International.

[57]  Julian R. Jones,et al.  Differentiation of fetal osteoblasts and formation of mineralized bone nodules by 45S5 Bioglass conditioned medium in the absence of osteogenic supplements. , 2009, Biomaterials.

[58]  Ralf J Kohal,et al.  The gene-expression and phenotypic response of hFOB 1.19 osteoblasts to surface-modified titanium and zirconia. , 2009, Biomaterials.

[59]  E. Brown,et al.  The Calcium-sensing Receptor Is Involved in Strontium Ranelate-induced Osteoclast Apoptosis , 2009, Journal of Biological Chemistry.

[60]  J. Cha,et al.  The incorporation of 70s bioactive glass to the osteogenic differentiation of murine embryonic stem cells in 3D bioreactors , 2009, Journal of tissue engineering and regenerative medicine.

[61]  B. Clarke,et al.  Bisphosphonates: mechanism of action and role in clinical practice. , 2008, Mayo Clinic proceedings.

[62]  Takayoshi Suzuki,et al.  Gene expression profiling of human mesenchymal stem cells for identification of novel markers in early- and late-stage cell culture. , 2008, Journal of biochemistry.

[63]  D. Lorich,et al.  Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. , 2008, The New England journal of medicine.

[64]  N. Watts,et al.  Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy , 2008, Osteoporosis International.

[65]  G. Reilly,et al.  Differential alkaline phosphatase responses of rat and human bone marrow derived mesenchymal stem cells to 45S5 bioactive glass. , 2007, Biomaterials.

[66]  Chung-Yuan Mou,et al.  The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells. , 2007, Biomaterials.

[67]  Yukio Nakamura,et al.  Mesenchymal Progenitors Able to Differentiate into Osteogenic, Chondrogenic, and/or Adipogenic Cells In Vitro Are Present in Most Primary Fibroblast‐Like Cell Populations , 2007, Stem cells.

[68]  A. Tosteson,et al.  Incidence and Economic Burden of Osteoporosis‐Related Fractures in the United States, 2005–2025 , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[69]  J. Reginster,et al.  Strontium ranelate for preventing and treating postmenopausal osteoporosis. , 2006, The Cochrane database of systematic reviews.

[70]  David J Mooney,et al.  Coating of VEGF-releasing scaffolds with bioactive glass for angiogenesis and bone regeneration. , 2006, Biomaterials.

[71]  M. Rogers,et al.  Recent advances in understanding the mechanism of action of bisphosphonates. , 2006, Current opinion in pharmacology.

[72]  Antonios G Mikos,et al.  In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[73]  G. Stein,et al.  The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cells. , 2006, Gene.

[74]  Wei-Hsuan Chen,et al.  Highly efficient cellular labeling of mesoporous nanoparticles in human mesenchymal stem cells: implication for stem cell tracking , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[75]  G. Stein,et al.  The Runx2 Osteogenic Transcription Factor Regulates Matrix Metalloproteinase 9 in Bone Metastatic Cancer Cells and Controls Cell Invasion , 2005, Molecular and Cellular Biology.

[76]  M. Bosetti,et al.  The effect of bioactive glasses on bone marrow stromal cells differentiation. , 2005, Biomaterials.

[77]  J. Polak,et al.  Enhanced derivation of osteogenic cells from murine embryonic stem cells after treatment with ionic dissolution products of 58S bioactive sol-gel glass. , 2005, Tissue engineering.

[78]  M. Ruat,et al.  In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor. , 2004, Biochemical and biophysical research communications.

[79]  F. Barry,et al.  Mesenchymal stem cells: clinical applications and biological characterization. , 2004, The international journal of biochemistry & cell biology.

[80]  Antonio Nanci,et al.  Nanotexturing of titanium-based surfaces upregulates expression of bone sialoprotein and osteopontin by cultured osteogenic cells. , 2004, Biomaterials.

[81]  B. Riggs,et al.  Changes in Runx2/Cbfa1 Expression and Activity During Osteoblastic Differentiation of Human Bone Marrow Stromal Cells , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[82]  P. Meunier,et al.  Effects of bisphosphonates on matrix mineralization. , 2002, Journal of musculoskeletal & neuronal interactions.

[83]  Rui F. Silva,et al.  Si3N4-bioglass composites stimulate the proliferation of MG63 osteoblast-like cells and support the osteogenic differentiation of human bone marrow cells , 2002 .

[84]  J. Reginster Strontium ranelate in osteoporosis. , 2002, Current pharmaceutical design.

[85]  G. Stein,et al.  Expression of the Osteoblast Differentiation Factor RUNX2 (Cbfa1/AML3/Pebp2αA) Is Inhibited by Tumor Necrosis Factor-α* , 2002, The Journal of Biological Chemistry.

[86]  J. Deng,et al.  The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation , 2002, Cell.

[87]  G. Karsenty Minireview: transcriptional control of osteoblast differentiation. , 2001, Endocrinology.

[88]  L L Hench,et al.  Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution. , 2001, Journal of biomedical materials research.

[89]  C. Christiansen,et al.  Incorporation and distribution of strontium in bone. , 2001, Bone.

[90]  I. Silver,et al.  Interactions of bioactive glasses with osteoblasts in vitro: effects of 45S5 Bioglass, and 58S and 77S bioactive glasses on metabolism, intracellular ion concentrations and cell viability. , 2001, Biomaterials.

[91]  R. Burge,et al.  The cost of osteoporotic fractures in the UK: projections for 2000–2020 , 2001 .

[92]  J. Polak,et al.  Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. , 2000, Biochemical and biophysical research communications.

[93]  G. Karsenty,et al.  The osteoblast: a sophisticated fibroblast under central surveillance. , 2000, Science.

[94]  M. H. Fernandes,et al.  Human bone cell cultures in biocompatibility testing. Part II: effect of ascorbic acid, beta-glycerophosphate and dexamethasone on osteoblastic differentiation. , 2000, Biomaterials.

[95]  A. Cabral,et al.  Human bone cell cultures in biocompatibility testing. Part I: osteoblastic differentiation of serially passaged human bone marrow cells cultured in alpha-MEM and in DMEM. , 2000, Biomaterials.

[96]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[97]  L. Melton,et al.  The worldwide problem of osteoporosis: insights afforded by epidemiology. , 1995, Bone.

[98]  S. Cummings,et al.  Which Fractures Are Associated with Low Appendicular Bone Mass in Elderly Women , 1991 .

[99]  Larry L. Hench,et al.  Bonding mechanisms at the interface of ceramic prosthetic materials , 1971 .

[100]  L. Hench,et al.  Gene activating glasses , 2020, Physics and Chemistry of Glasses: European Journal of Glass Science and Technology Part B.

[101]  A. Seifalian,et al.  Osteogenic potential of stem cells-seeded bioactive nanocomposite scaffolds: A comparative study between human mesenchymal stem cells derived from bone, umbilical cord Wharton's jelly, and adipose tissue. , 2018, Journal of biomedical materials research. Part B, Applied biomaterials.

[102]  A. Ardeshirylajimi,et al.  Improved proliferation and osteogenic differentiation of mesenchymal stem cells on polyaniline composited by polyethersulfone nanofibers. , 2017, Biologicals : journal of the International Association of Biological Standardization.

[103]  Julian R. Jones,et al.  Monodispersed Bioactive Glass Submicron Particles and Their Effect on Bone Marrow and Adipose Tissue‐Derived Stem Cells , 2014, Advanced healthcare materials.

[104]  V. Labhasetwar,et al.  Nanoparticles: cellular uptake and cytotoxicity. , 2014, Advances in experimental medicine and biology.

[105]  M. Bohner,et al.  Resorbable biomaterials as bone graft substitutes , 2010 .

[106]  R. Cabrini,et al.  Osteoconductivity of strontium-doped bioactive glass particles: a histomorphometric study in rats. , 2010, Journal of biomedical materials research. Part A.

[107]  R. Cesareo,et al.  Strontium ranelate in postmenopausal osteoporosis treatment: a critical appraisal , 2009 .

[108]  F. Saltel,et al.  Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. , 2008, Bone.

[109]  D. Prockop,et al.  Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. , 2006, Cytotherapy.

[110]  B. Ganss,et al.  Bone sialoprotein. , 1999, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[111]  G. Stein,et al.  Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation. , 1995, The Iowa orthopaedic journal.

[112]  T. Stigbrand Present status and future trends of human alkaline phosphatases. , 1984, Progress in clinical and biological research.

[113]  J. Potus,et al.  Use of alizarin red S for histochemical staining of Ca2+ in the mouse; some parameters of the chemical reaction in vitro. , 1982, Acta anatomica.