The effects of hippocampectomy on alternation behavior and response of novelty.

Abstract Rats with hippocampal lesions, cortical lesions and unoperated rats were tested for maze activity, spontaneous alternation, food-reinforced alternation, perseveration of the alternation response, and response to a novel alley before and after training. The animals with hippocampal lesions were more active in the maze and deficient on spontaneous and food-reinforced alternation, compared with the animals with cortical lesions and normal animals. Further, the hippocampectomized rats did not perseverate the alternation response and failed to enter a relatively novel alley when tested after maze training. Animals in both control groups (cortical and normal) entered the novel alley with equal frequency on tests given both before and after maze training.

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