Two-year toxicity and carcinogenicity studies in B(6)C(3)F(1) mice with 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent.

[1]  O. D'cruz,et al.  Gel-microemulsions as vaginal spermicides and intravaginal drug delivery vehicles. , 2001, Contraception.

[2]  F. Uckun,et al.  Lack of adverse effects on fertility of female cd‐1 mice exposed to repetitive intravaginal gel–microemulsion formulation of a dual‐function anti‐HIV agent: aryl phosphate derivative of bromo‐methoxy‐zidovudine (compound WHI‐07) , 2001, Journal of applied toxicology : JAT.

[3]  F. Uckun,et al.  Short-Term (13-week) toxicity study of 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent, in B6C3F1 mice. , 2001, Toxicological sciences : an official journal of the Society of Toxicology.

[4]  F. Uckun,et al.  Evaluation of subchronic (13‐week) and reproductive toxicity potential of intravaginal gel–microemulsion formulation of a dual‐function phenyl phosphate derivative of bromo‐methoxy zidovudine (compound whi‐07) in B6C3F1 mice , 2000, Journal of applied toxicology : JAT.

[5]  T. Quinn,et al.  Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. , 2000, The New England journal of medicine.

[6]  F. Uckun,et al.  Prophylactic contraceptives for HIV/AIDS. , 1999, Human reproduction update.

[7]  F. Uckun,et al.  Synthesis, characterization and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities. , 1999, Molecular human reproduction.

[8]  J. Aubrecht,et al.  Molecular genotoxicity profiles of apoptosis-inducing vanadocene complexes. , 1999, Toxicology and applied pharmacology.

[9]  F. Uckun,et al.  Synthesis of Dual Function (5R,6R)- and (5S,6S)-5-Bromo-6-Methoxy-5,6-Dihydro-AZT-5′-(Para-Bromophenyl Methoxyalaninyl Phosphate) as Novel Spermicidal and Anti-HIV Agents , 1999, Antiviral chemistry & chemotherapy.

[10]  F. Uckun,et al.  Aryl phosphate derivatives of bromo-methoxy-azidothymidine are dual-function spermicides with potent anti-human immunodeficiency virus. , 1998, Biology of reproduction.

[11]  B. Lundberg A Submicron Lipid Emulsion Coated with Amphipathic Polyethylene Glycol for Parenteral Administration of Paclitaxel (Taxol) , 1997, The Journal of pharmacy and pharmacology.

[12]  R. Borchardt,et al.  The Use of Surfactants to Enhance the Permeability of Peptides Through Caco-2 Cells by Inhibition of an Apically Polarized Efflux System , 1996, Pharmaceutical Research.

[13]  R. Irwin,et al.  Hematologic toxicity of AZT and ddC administered as single agents and in combination to rats and mice. , 1991, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[14]  H. Mitsuya,et al.  Hematologic effects of AIDS therapies. , 1991, Hematology/oncology clinics of North America.

[15]  L S Birnbaum,et al.  Mouse strains for chemical carcinogenicity studies: overview of a workshop. , 1988, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[16]  R. Alison,et al.  Nonneoplastic lesions of the ovary in Fischer 344 rats and B6C3F1 mice. , 1987, Environmental health perspectives.

[17]  Rao Gn,et al.  Utero-ovarian infection in aged B6C3F1 mice. , 1987 .

[18]  J M Ward,et al.  Variability in the rates of some common naturally occurring tumors in Fischer 344 rats and (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice. , 1981, Journal of the National Cancer Institute.

[19]  J M Ward,et al.  Neoplastic and nonneoplastic lesions in aging (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice. , 1979, Journal of the National Cancer Institute.

[20]  F. Uckun,et al.  Thymidine Kinase-Independent Intracellular Delivery of Bioactive Nucleotides by Aryl Phosphate Derivatives of Bromo-Methoxy Zidovudine (Compounds WHI-05 and WHI-07) in Normal Human Female Genital Tract Epithelial Cells and Sperm1 , 2001, Biology of reproduction.

[21]  F. Uckun,et al.  Structural Requirements for Potent Human Spermicidal Activity of Dual-Function Aryl Phosphate Derivative of Bromo-Methoxy Zidovudine (Compound WHI-07)1 , 2000, Biology of reproduction.

[22]  T. Dragani,et al.  Long-term assays for carcinogenicity. , 1990, Teratogenesis, carcinogenesis, and mutagenesis.

[23]  S. Charbonneau,et al.  Monitoring animal health during chronic toxicity studies. , 1977, Journal of environmental pathology and toxicology.