Cholesterol Hydroperoxide - A Potential Cardiac Hazard

antituberculous chemotherapy was curative. In the 3 patients with disseminated tuberculosis, we were Successful in eradicating the infection in 2. The other patient developed jaundice presumably due to rifampicin and both that drug and immunosuppressives had to be withheld. Difficult though it may be, every attempt should be made to detect the presence of tuberculosis prior to renal transplantation, so that adequate antituberculous treatment can be given before the patient is exposed to immunosuppressive agents. Bell & Williams have demonstrated how difficult it can be to establish the diagnosis of tuberculosis in immunosuppressed patients. All possible diagnostic procedures should be recruited and, if need be, lung biopsies should be undertaken. The dangers of these invasive investigations must, of course, be weighed against the dangers of misdiagnosis. Provided drug toxicity can be avoided, it has been shown that successful antituberculous therapy can be given and the disease cured even in the presence of immunosuppression. Whether or not prophylactic treatment with INAH should be continued after transplantation is uncertain.