NPM-ALK gene fusion and Hodgkin's disease.

To the Editor: The t(2; 5)(p23; q35) is an established cytogenetic abnormality associated with 40% of cases of anaplastic large-cell lymphoma (ALCL). Cloning of the translocation breakpoint has shown the fusion of a previously unidentified protein tyrosine kinase, anaplastic lymphoma kinase (ALK)

[1]  M. Waasdorp,et al.  Amplification of genomic DNA demonstrates the presence of the t(2;5) (p23;q35) in anaplastic large cell lymphoma, but not in other non-Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis. , 1996, Blood.

[2]  S. Pittaluga,et al.  Molecular characterization of the t(2;5) (p23; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease. , 1996, Blood.

[3]  A. Feller,et al.  Presence of the t(2;5) in Hodgkin's disease. , 1995, Blood.

[4]  P. Hopewell,et al.  How to treat bacteraemic Mycobacterium avium complex disease , 1995, The Lancet.

[5]  M. Ladanyi,et al.  Large-cell anaplastic lymphoma-specific translocation in Hodgkin's disease , 1995, The Lancet.

[6]  D. Mason,et al.  Detection of NPM‐ALK DNA rearrangement in CD30 positive anaplastic large cell lymphoma , 1995, British journal of haematology.

[7]  A. Feller,et al.  Large-cell anaplastic lymphoma-specific translocation (t[2;5] [p23;q35]) in Hodgkin's disease: indication of a common pathogenesis? , 1995, The Lancet.

[8]  D N Shapiro,et al.  Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. , 1994, Science.

[9]  W. Dalton,et al.  Effects of ethanol and paraformaldehyde on RNA yield and quality. , 1994, BioTechniques.

[10]  S. Pileri,et al.  Nucleophosmin (NPM) gene rearrangements in Ki-1-positive lymphomas. , 1994, Cancer research.

[11]  J. M. Goldman,et al.  APPROPRIATE CONTROLS FOR REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION (RT‐PCR) , 1994, British journal of haematology.