In this study, the combination of etodolac and colchicine was studied for its anti-inflammatory activity. Thirty rats of either sex were divided into five groups’ viz. control (received vehicle); an etodolac alone (received 46 mg/kg etodolac); colchicine alone (received 0.23 mg/kg colchicine), low dose combination of etodolac and colchicine (received 23 mg/kg etodolac plus 0.11 mg /kg colchicine) and high dose combination of etodolac and colchicine (received 46 mg/kg etodolac plus 0.23 mg/kg colchicine) of six animals each. The anti-inflammatory activity of the drugs was tested in carrageenan-induced rat-paw oedema. The high dose combination of etodolac (46 mg/kg) and colchicine (0.23 mg/kg) showed 85.29 % inhibition and low dose combination of etodolac (23 mg/kg) and colchicines (0.11 mg/kg) showed 82.35% inhibition on carrageenan induced rat paw oedema. The results of this study reveal that high dose combination of etodolac and colchicine has significantly higher (p<0.05) anti-inflammatory activity than etodolac or colchicine alone.
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