Tissue Response to Pre-Degraded Poly(L-Lactide)

Poly(L-lactide) is a member of a group biodegradable aliphatic poly(lactone)esters which have found important use as biomaterials e. g. in prosthetics, sutures, and drug delivery systems. As-polymerized, high molecular weight poly(L-laetide) (PLLA) as synthesized according to Leenslag et al.1has been successfully used for fracture fixation and orbital floor reconstruction in animals and humans2-5. PLLA is considered to be a fully resorbable, biocompatible material6.

[1]  G. Boering,et al.  Resorbable poly(L-lactide) plates and screws for the fixation of zygomatic fractures. , 1987, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[2]  G. Boering,et al.  Resorbable materials of poly(L-lactide). VI. Plates and screws for internal fracture fixation. , 1987, Biomaterials.

[3]  A. Pennings,et al.  Bio-absorbable plates and screws for internal fixation of mandibular fractures. A study in six dogs. , 1989, International journal of oral and maxillofacial surgery.

[4]  A. Pennings,et al.  Bone-plates and screws of bioabsorbable poly (L-lactide)--an animal pilot study. , 1989, The British journal of oral & maxillofacial surgery.

[5]  J. van Dort,et al.  Quantitative energy-filtered image analysis in cytochemistry. II. Morphometric analysis of element-distribution images. , 1990, Ultramicroscopy.

[6]  W. D. de Bruijn,et al.  Quantitative energy-filtered image analysis in cytochemistry. I. Morphometric analysis of contrast-related images. , 1990, Ultramicroscopy.

[7]  A. Pennings,et al.  Poly(L-lactide) implants in repair of defects of the orbital floor: an animal study. , 1990, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[8]  R. Bos,et al.  Degradation of and tissue reaction to biodegradable poly(L-lactide) for use as internal fixation of fractures: a study in rats. , 1991, Biomaterials.

[9]  F. Rozema.  Resorbable poly(L-lactide) bone plates and screws , 1991 .