Acidosis-induced regulation of adipocyte G0S2 promotes crosstalk between adipocytes and breast cancer cells as well as tumor progression.

[1]  E. Lengyel,et al.  The adipocyte microenvironment and cancer , 2022, Cancer and Metastasis Reviews.

[2]  S. Mandrup,et al.  Lipolysis regulates major transcriptional programs in brown adipocytes , 2022, Nature Communications.

[3]  Neng Zhu,et al.  New dawn for cancer cell death: Emerging role of lipid metabolism , 2022, Molecular metabolism.

[4]  Y. Wang,et al.  Contribution of adipocytes in the tumor microenvironment to breast cancer metabolism. , 2022, Cancer letters.

[5]  Shenmin Zhang,et al.  The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders , 2022, Cell Death & Disease.

[6]  O. Thews,et al.  Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo , 2021, Journal of experimental & clinical cancer research : CR.

[7]  C. Muller,et al.  Drilling for Oil: Tumor-Surrounding Adipocytes Fueling Cancer. , 2020, Trends in cancer.

[8]  Alexander Yang,et al.  Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics. , 2020, The Biochemical journal.

[9]  Wei-min Deng,et al.  The role of pro-inflammatory cytokines in lipid metabolism of metabolic diseases , 2019, International reviews of immunology.

[10]  R. Gillies,et al.  Causes, consequences, and therapy of tumors acidosis , 2019, Cancer and Metastasis Reviews.

[11]  S. Avnet,et al.  Cause and effect of microenvironmental acidosis on bone metastases , 2019, Cancer and Metastasis Reviews.

[12]  D. Lauffenburger,et al.  Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes. , 2019, Cancer research.

[13]  Xia Li,et al.  Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP) , 2019, Breast Cancer Research.

[14]  P. Valet,et al.  Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress , 2019, Molecular Cancer Research.

[15]  J. Geffner,et al.  Unravelling the Interplay between Extracellular Acidosis and Immune Cells , 2018, Mediators of inflammation.

[16]  P. Delvenne,et al.  Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness , 2018, Oncogene.

[17]  E. Lengyel,et al.  Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors. , 2018, Trends in cancer.

[18]  L. Campbell,et al.  G0S2: A small giant controller of lipolysis and adipose-liver fatty acid flux. , 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[19]  C. Supuran,et al.  Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis , 2017, Journal of Molecular Medicine.

[20]  D. Saunders,et al.  Adipocyte-Tumor Cell Metabolic Crosstalk in Breast Cancer. , 2017, Trends in molecular medicine.

[21]  C. Muller,et al.  Obesity and melanoma: could fat be fueling malignancy? , 2017, Pigment cell & melanoma research.

[22]  M. Prentki,et al.  Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells. , 2017, JCI insight.

[23]  D. Fazakerley,et al.  Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration , 2017, Cancer & metabolism.

[24]  Bradlee L. Heckmann,et al.  Regulation of G0/G1 Switch Gene 2 (G0S2) Protein Ubiquitination and Stability by Triglyceride Accumulation and ATGL Interaction , 2016, PloS one.

[25]  J. Stephens,et al.  Metabolic Control by Inflammation and Immunity Fat in flames : influence of cytokines and pattern recognition receptors on adipocyte lipolysis , 2015 .

[26]  Thierry Arnould,et al.  Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment , 2015, Oncotarget.

[27]  Yiduo He,et al.  TNF-α reduces g0s2 expression and stimulates lipolysis through PPAR-γ inhibition in 3T3-L1 adipocytes. , 2014, Cytokine.

[28]  S. Mandrup,et al.  Peroxisome Proliferator-Activated Receptor γ and C/EBPα Synergistically Activate Key Metabolic Adipocyte Genes by Assisted Loading , 2013, Molecular and Cellular Biology.

[29]  Xin-Yun Lu,et al.  Defective Adipose Lipolysis and Altered Global Energy Metabolism in Mice with Adipose Overexpression of the Lipolytic Inhibitor G0/G1 Switch Gene 2 (G0S2)* , 2013, The Journal of Biological Chemistry.

[30]  E. Lengyel,et al.  Adipose tissue and adipocytes support tumorigenesis and metastasis. , 2013, Biochimica et biophysica acta.

[31]  Robert J Gillies,et al.  Acidity generated by the tumor microenvironment drives local invasion. , 2013, Cancer research.

[32]  Douglas Hanahan,et al.  Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment Prospects and Obstacles for Therapeutic Targeting of Function-enabling Stromal Cell Types , 2022 .

[33]  G. Mills,et al.  Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth , 2011, Nature Medicine.

[34]  R. Gillies,et al.  Drug resistance and cellular adaptation to tumor acidic pH microenvironment. , 2011, Molecular pharmaceutics.

[35]  Yuan Yuan Wang,et al.  Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. , 2011, Cancer research.

[36]  Xin Lu,et al.  The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. , 2010, Cell metabolism.

[37]  E. Petricoin,et al.  Periprostatic adipose tissue as a modulator of prostate cancer aggressiveness. , 2009, The Journal of urology.

[38]  M. Czaja,et al.  Autophagy regulates lipid metabolism , 2009, Nature.

[39]  A. Tzatsos,et al.  Energy Depletion Inhibits Phosphatidylinositol 3-Kinase/Akt Signaling and Induces Apoptosis via AMP-activated Protein Kinase-dependent Phosphorylation of IRS-1 at Ser-794* , 2007, Journal of Biological Chemistry.

[40]  O. MacDougald,et al.  Adipocyte differentiation from the inside out , 2006, Nature Reviews Molecular Cell Biology.

[41]  J. Pouysségur,et al.  Hypoxia signalling in cancer and approaches to enforce tumour regression , 2006, Nature.

[42]  E. T. Gawlinski,et al.  Acid-mediated tumor invasion: a multidisciplinary study. , 2006, Cancer research.

[43]  T. Jatkoe,et al.  The G0/G1 switch gene 2 is a novel PPAR target gene. , 2005, The Biochemical journal.

[44]  M. Federici,et al.  Phosphorylation of GATA2 by Akt Increases Adipose Tissue Differentiation and Reduces Adipose Tissue–Related Inflammation: A Novel Pathway Linking Obesity to Atherosclerosis , 2005, Circulation.

[45]  M. Lazar,et al.  Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. , 2005, Genes & development.

[46]  Q. Tong,et al.  Interaction between GATA and the C/EBP Family of Transcription Factors Is Critical in GATA-Mediated Suppression of Adipocyte Differentiation , 2005, Molecular and Cellular Biology.

[47]  O. Thews,et al.  Acidosis Promotes Metastasis Formation by Enhancing Tumor Cell Motility. , 2016, Advances in experimental medicine and biology.

[48]  Lee,et al.  Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652 , 2016 .

[49]  B. Spiegelman,et al.  C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. , 2002, Genes & development.